FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964214627> ?p ?o ?g. }

• W1964214627 endingPage "e96901" @default.
• W1964214627 startingPage "e96901" @default.
• W1964214627 abstract "Threatened preterm labor (TPTL) is defined as persistent premature uterine contractions between 20 and 37 weeks of gestation and is the most common condition that requires hospitalization during pregnancy. Most of these TPTL women continue their pregnancies to term while only an estimated 5% will deliver a premature baby within ten days. The aim of this work was to study differential whole blood gene expression associated with spontaneous preterm birth (sPTB) within 48 hours of hospital admission. Peripheral blood was collected at point of hospital admission from 154 women with TPTL before any medical treatment. Microarrays were utilized to investigate differential whole blood gene expression between TPTL women who did (n = 48) or did not have a sPTB (n = 106) within 48 hours of admission. Total leukocyte and neutrophil counts were significantly higher (35% and 41% respectively) in women who had sPTB than women who did not deliver within 48 hours (p<0.001). Fetal fibronectin (fFN) test was performed on 62 women. There was no difference in the urine, vaginal and placental microbiology and histopathology reports between the two groups of women. There were 469 significant differentially expressed genes (FDR<0.05); 28 differentially expressed genes were chosen for microarray validation using qRT-PCR and 20 out of 28 genes were successfully validated (p<0.05). An optimal random forest classifier model to predict sPTB was achieved using the top nine differentially expressed genes coupled with peripheral clinical blood data (sensitivity 70.8%, specificity 75.5%). These differentially expressed genes may further elucidate the underlying mechanisms of sPTB and pave the way for future systems biology studies to predict sPTB." @default.
• W1964214627 created "2016-06-24" @default.
• W1964214627 creator A5013444368 @default.
• W1964214627 creator A5032904180 @default.
• W1964214627 creator A5034116068 @default.
• W1964214627 creator A5056590153 @default.
• W1964214627 creator A5076433645 @default.
• W1964214627 date "2014-05-14" @default.
• W1964214627 modified "2023-10-16" @default.
• W1964214627 title "Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor" @default.
• W1964214627 cites W1527927437 @default.
• W1964214627 cites W1559781975 @default.
• W1964214627 cites W1577577364 @default.
• W1964214627 cites W1583052686 @default.
• W1964214627 cites W1696199194 @default.
• W1964214627 cites W1888697012 @default.
• W1964214627 cites W1969435285 @default.
• W1964214627 cites W1975755498 @default.
• W1964214627 cites W1977203954 @default.
• W1964214627 cites W1980110976 @default.
• W1964214627 cites W1980263308 @default.
• W1964214627 cites W1982153837 @default.
• W1964214627 cites W1983268079 @default.
• W1964214627 cites W1989666280 @default.
• W1964214627 cites W1990946778 @default.
• W1964214627 cites W1993731327 @default.
• W1964214627 cites W1994295830 @default.
• W1964214627 cites W1994663031 @default.
• W1964214627 cites W1999895438 @default.
• W1964214627 cites W2009463518 @default.
• W1964214627 cites W2016901788 @default.
• W1964214627 cites W2018097513 @default.
• W1964214627 cites W2018508542 @default.
• W1964214627 cites W2019965198 @default.
• W1964214627 cites W2022576868 @default.
• W1964214627 cites W2024188630 @default.
• W1964214627 cites W2033139829 @default.
• W1964214627 cites W2034139619 @default.
• W1964214627 cites W2038019990 @default.
• W1964214627 cites W2039416528 @default.
• W1964214627 cites W2040151674 @default.
• W1964214627 cites W2041102049 @default.
• W1964214627 cites W2044152361 @default.
• W1964214627 cites W2044273443 @default.
• W1964214627 cites W2046987032 @default.
• W1964214627 cites W2046993573 @default.
• W1964214627 cites W2058987514 @default.
• W1964214627 cites W2068347916 @default.
• W1964214627 cites W2069724214 @default.
• W1964214627 cites W2073637502 @default.
• W1964214627 cites W2076893595 @default.
• W1964214627 cites W2078493611 @default.
• W1964214627 cites W2081098333 @default.
• W1964214627 cites W2091315110 @default.
• W1964214627 cites W2101217670 @default.
• W1964214627 cites W2109812871 @default.
• W1964214627 cites W2111379723 @default.
• W1964214627 cites W2111653091 @default.
• W1964214627 cites W2113166434 @default.
• W1964214627 cites W2114477597 @default.
• W1964214627 cites W2115962953 @default.
• W1964214627 cites W2118030557 @default.
• W1964214627 cites W2122985395 @default.
• W1964214627 cites W2126879455 @default.
• W1964214627 cites W2127757901 @default.
• W1964214627 cites W2128991285 @default.
• W1964214627 cites W2129236569 @default.
• W1964214627 cites W2135145601 @default.
• W1964214627 cites W2135827569 @default.
• W1964214627 cites W2140480751 @default.
• W1964214627 cites W2143289194 @default.
• W1964214627 cites W2144056966 @default.
• W1964214627 cites W2144926476 @default.
• W1964214627 cites W2150982004 @default.
• W1964214627 cites W2151936673 @default.
• W1964214627 cites W2158124686 @default.
• W1964214627 cites W2158217645 @default.
• W1964214627 cites W2160699408 @default.
• W1964214627 cites W2161807833 @default.
• W1964214627 cites W2164197794 @default.
• W1964214627 cites W2164726190 @default.
• W1964214627 cites W2166574880 @default.
• W1964214627 cites W2187723131 @default.
• W1964214627 cites W2324970443 @default.
• W1964214627 cites W4248639845 @default.
• W1964214627 doi "https://doi.org/10.1371/journal.pone.0096901" @default.
• W1964214627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4020779" @default.
• W1964214627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24828675" @default.
• W1964214627 hasPublicationYear "2014" @default.
• W1964214627 type Work @default.
• W1964214627 sameAs 1964214627 @default.
• W1964214627 citedByCount "53" @default.
• W1964214627 countsByYear W19642146272014 @default.
• W1964214627 countsByYear W19642146272015 @default.
• W1964214627 countsByYear W19642146272016 @default.
• W1964214627 countsByYear W19642146272017 @default.
• W1964214627 countsByYear W19642146272018 @default.
• W1964214627 countsByYear W19642146272019 @default.

• next