Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964229968> ?p ?o ?g. }
- W1964229968 endingPage "393" @default.
- W1964229968 startingPage "381" @default.
- W1964229968 abstract "‘Protective autoimmunity’ refers to a well-controlled anti-self response that helps the body resist neurodegeneration . The response is mediated by autoimmune T cells , which produce cytokines and growth factors. Using an in vitro assay of hippocampal slices, we show that the cytokines interferon-γ and (especially) interleukin-4, characteristic of pro-inflammatory and anti-inflammatory T cells, respectively, can make microglia neuroprotective . Aggregated β-amyloid, like bacterial cell wall-derived lipopolysaccharide , rendered the microglia cytotoxic. Cytotoxicity was correlated with a signal transduction pathway that down-regulates expression of class-II major histocompatibility proteins (MHC-II) through the MHC-II-transactivator and the invariant chain . Protection by interleukin-4 was attributed to down-regulation of tumor necrosis factor-α and up-regulation of insulin-like growth factor I. These findings suggest that beneficial or harmful expression of the local immune response in the damaged CNS depends on how microglia interpret the threat, and that a well-regulated T-cell-mediated response enables microglia to alleviate rather than exacerbate stressful situations in the CNS." @default.
- W1964229968 created "2016-06-24" @default.
- W1964229968 creator A5010190960 @default.
- W1964229968 creator A5013475771 @default.
- W1964229968 creator A5021643357 @default.
- W1964229968 creator A5034067729 @default.
- W1964229968 date "2005-07-01" @default.
- W1964229968 modified "2023-10-05" @default.
- W1964229968 title "Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective" @default.
- W1964229968 cites W1536622417 @default.
- W1964229968 cites W1547225066 @default.
- W1964229968 cites W1547955534 @default.
- W1964229968 cites W1600123087 @default.
- W1964229968 cites W1831659107 @default.
- W1964229968 cites W1963870368 @default.
- W1964229968 cites W1965275873 @default.
- W1964229968 cites W1967547992 @default.
- W1964229968 cites W1977100089 @default.
- W1964229968 cites W1983422527 @default.
- W1964229968 cites W1993441406 @default.
- W1964229968 cites W1997422264 @default.
- W1964229968 cites W2003884388 @default.
- W1964229968 cites W2010441033 @default.
- W1964229968 cites W2022362212 @default.
- W1964229968 cites W2030908648 @default.
- W1964229968 cites W2032490930 @default.
- W1964229968 cites W2039060098 @default.
- W1964229968 cites W2040838085 @default.
- W1964229968 cites W2058360762 @default.
- W1964229968 cites W2059028717 @default.
- W1964229968 cites W2063986567 @default.
- W1964229968 cites W2064645610 @default.
- W1964229968 cites W2068872768 @default.
- W1964229968 cites W2074011568 @default.
- W1964229968 cites W2083286809 @default.
- W1964229968 cites W2083817323 @default.
- W1964229968 cites W2086025690 @default.
- W1964229968 cites W2090971781 @default.
- W1964229968 cites W2095772035 @default.
- W1964229968 cites W2101596476 @default.
- W1964229968 cites W2103565638 @default.
- W1964229968 cites W2106181827 @default.
- W1964229968 cites W2111992141 @default.
- W1964229968 cites W2116784956 @default.
- W1964229968 cites W2117976722 @default.
- W1964229968 cites W2120819751 @default.
- W1964229968 cites W2125691088 @default.
- W1964229968 cites W2129704291 @default.
- W1964229968 cites W2135482947 @default.
- W1964229968 cites W2137569088 @default.
- W1964229968 cites W2149399096 @default.
- W1964229968 cites W2152286012 @default.
- W1964229968 cites W2164975710 @default.
- W1964229968 cites W2328332609 @default.
- W1964229968 cites W4251884284 @default.
- W1964229968 doi "https://doi.org/10.1016/j.mcn.2005.03.005" @default.
- W1964229968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15890528" @default.
- W1964229968 hasPublicationYear "2005" @default.
- W1964229968 type Work @default.
- W1964229968 sameAs 1964229968 @default.
- W1964229968 citedByCount "333" @default.
- W1964229968 countsByYear W19642299682012 @default.
- W1964229968 countsByYear W19642299682013 @default.
- W1964229968 countsByYear W19642299682014 @default.
- W1964229968 countsByYear W19642299682015 @default.
- W1964229968 countsByYear W19642299682016 @default.
- W1964229968 countsByYear W19642299682017 @default.
- W1964229968 countsByYear W19642299682018 @default.
- W1964229968 countsByYear W19642299682019 @default.
- W1964229968 countsByYear W19642299682020 @default.
- W1964229968 countsByYear W19642299682021 @default.
- W1964229968 countsByYear W19642299682022 @default.
- W1964229968 countsByYear W19642299682023 @default.
- W1964229968 crossrefType "journal-article" @default.
- W1964229968 hasAuthorship W1964229968A5010190960 @default.
- W1964229968 hasAuthorship W1964229968A5013475771 @default.
- W1964229968 hasAuthorship W1964229968A5021643357 @default.
- W1964229968 hasAuthorship W1964229968A5034067729 @default.
- W1964229968 hasConcept C154317977 @default.
- W1964229968 hasConcept C169760540 @default.
- W1964229968 hasConcept C17991360 @default.
- W1964229968 hasConcept C202751555 @default.
- W1964229968 hasConcept C203014093 @default.
- W1964229968 hasConcept C207936829 @default.
- W1964229968 hasConcept C25498285 @default.
- W1964229968 hasConcept C2776914184 @default.
- W1964229968 hasConcept C2778754761 @default.
- W1964229968 hasConcept C2779830541 @default.
- W1964229968 hasConcept C55493867 @default.
- W1964229968 hasConcept C86803240 @default.
- W1964229968 hasConcept C8891405 @default.
- W1964229968 hasConcept C95444343 @default.
- W1964229968 hasConceptScore W1964229968C154317977 @default.
- W1964229968 hasConceptScore W1964229968C169760540 @default.
- W1964229968 hasConceptScore W1964229968C17991360 @default.
- W1964229968 hasConceptScore W1964229968C202751555 @default.
- W1964229968 hasConceptScore W1964229968C203014093 @default.
- W1964229968 hasConceptScore W1964229968C207936829 @default.