FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964236448> ?p ?o ?g. }

• W1964236448 endingPage "697" @default.
• W1964236448 startingPage "690" @default.
• W1964236448 abstract "Cutaneous carcinosarcomas are heterogeneous group of tumors composed of malignant epithelial and mesenchymal components. Although mutation analyses have identified clonal changes between these morphologically disparate components in some subtypes of cutaneous carcinosarcoma, few cases have been analyzed thus far. To our knowledge, copy number variations (CNVs) and copy-neutral loss of heterozygosity (CN-LOH) have not been investigated in cutaneous carcinosarcomas. We analyzed 4 carcinosarcomas with basal cell carcinoma and osteosarcomatous components for CNVs/CN-LOH by comparative genomic hybridization/single-nucleotide polymorphism array, TP53 hot spot mutations by polymerase chain reaction and Sanger sequencing, and TP53 genomic rearrangements by fluorescence in situ hybridization. All tumors displayed multiple CNV/CN-LOH events (median, 7.5 per tumor). Three of 4 tumors displayed similar CNV/CN-LOH patterns between the epithelial and mesenchymal components within each tumor, supporting a common clonal origin. Recurrent changes included allelic loss at 9p21 (CDKN2A), 9q (PTCH1), and 17p (TP53). Allelic losses of chromosome 16 including CDH1 (E-cadherin) were present in 2 tumors and were restricted to the sarcomatous component. TP53 mutation analysis revealed an R248L mutation in both epithelial and mesenchymal components of 1 tumor. No TP53 rearrangements were identified. Our findings indicate that basal cell carcinosarcomas harbor CNV/CN-LOH changes similar to conventional basal cell carcinoma, with additional changes including recurrent 9p21 losses and a relatively high burden of copy number changes. In addition, most cutaneous carcinosarcomas show evidence of clonality between epithelial and mesenchymal components." @default.
• W1964236448 created "2016-06-24" @default.
• W1964236448 creator A5009124370 @default.
• W1964236448 creator A5011641403 @default.
• W1964236448 creator A5015102287 @default.
• W1964236448 creator A5016216331 @default.
• W1964236448 creator A5028207368 @default.
• W1964236448 creator A5042167871 @default.
• W1964236448 creator A5043210092 @default.
• W1964236448 creator A5044405915 @default.
• W1964236448 creator A5051133829 @default.
• W1964236448 creator A5063290281 @default.
• W1964236448 creator A5063764614 @default.
• W1964236448 creator A5083968353 @default.
• W1964236448 creator A5084922819 @default.
• W1964236448 creator A5086349143 @default.
• W1964236448 date "2015-05-01" @default.
• W1964236448 modified "2023-10-03" @default.
• W1964236448 title "Cutaneous basal cell carcinosarcomas: evidence of clonality and recurrent chromosomal losses" @default.
• W1964236448 cites W1514674965 @default.
• W1964236448 cites W1548344101 @default.
• W1964236448 cites W1588529288 @default.
• W1964236448 cites W1806088394 @default.
• W1964236448 cites W1928023547 @default.
• W1964236448 cites W1952868082 @default.
• W1964236448 cites W1964572707 @default.
• W1964236448 cites W1975127503 @default.
• W1964236448 cites W1978739865 @default.
• W1964236448 cites W1979408274 @default.
• W1964236448 cites W1981996276 @default.
• W1964236448 cites W2006955666 @default.
• W1964236448 cites W2008950843 @default.
• W1964236448 cites W2010256904 @default.
• W1964236448 cites W2016371780 @default.
• W1964236448 cites W2019294425 @default.
• W1964236448 cites W2019788071 @default.
• W1964236448 cites W2030407268 @default.
• W1964236448 cites W2037058665 @default.
• W1964236448 cites W2066393145 @default.
• W1964236448 cites W2074523815 @default.
• W1964236448 cites W2077149593 @default.
• W1964236448 cites W2090134742 @default.
• W1964236448 cites W2091113670 @default.
• W1964236448 cites W2093189134 @default.
• W1964236448 cites W2117692326 @default.
• W1964236448 cites W2126150922 @default.
• W1964236448 cites W2144012557 @default.
• W1964236448 cites W2148843895 @default.
• W1964236448 cites W2327427995 @default.
• W1964236448 cites W2330740957 @default.
• W1964236448 cites W2410226749 @default.
• W1964236448 cites W29399532 @default.
• W1964236448 doi "https://doi.org/10.1016/j.humpath.2015.01.006" @default.
• W1964236448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25704628" @default.
• W1964236448 hasPublicationYear "2015" @default.
• W1964236448 type Work @default.
• W1964236448 sameAs 1964236448 @default.
• W1964236448 citedByCount "26" @default.
• W1964236448 countsByYear W19642364482015 @default.
• W1964236448 countsByYear W19642364482016 @default.
• W1964236448 countsByYear W19642364482017 @default.
• W1964236448 countsByYear W19642364482018 @default.
• W1964236448 countsByYear W19642364482019 @default.
• W1964236448 countsByYear W19642364482020 @default.
• W1964236448 countsByYear W19642364482021 @default.
• W1964236448 countsByYear W19642364482022 @default.
• W1964236448 crossrefType "journal-article" @default.
• W1964236448 hasAuthorship W1964236448A5009124370 @default.
• W1964236448 hasAuthorship W1964236448A5011641403 @default.
• W1964236448 hasAuthorship W1964236448A5015102287 @default.
• W1964236448 hasAuthorship W1964236448A5016216331 @default.
• W1964236448 hasAuthorship W1964236448A5028207368 @default.
• W1964236448 hasAuthorship W1964236448A5042167871 @default.
• W1964236448 hasAuthorship W1964236448A5043210092 @default.
• W1964236448 hasAuthorship W1964236448A5044405915 @default.
• W1964236448 hasAuthorship W1964236448A5051133829 @default.
• W1964236448 hasAuthorship W1964236448A5063290281 @default.
• W1964236448 hasAuthorship W1964236448A5063764614 @default.
• W1964236448 hasAuthorship W1964236448A5083968353 @default.
• W1964236448 hasAuthorship W1964236448A5084922819 @default.
• W1964236448 hasAuthorship W1964236448A5086349143 @default.
• W1964236448 hasConcept C104317684 @default.
• W1964236448 hasConcept C121608353 @default.
• W1964236448 hasConcept C124942203 @default.
• W1964236448 hasConcept C142724271 @default.
• W1964236448 hasConcept C143589142 @default.
• W1964236448 hasConcept C180754005 @default.
• W1964236448 hasConcept C2777542201 @default.
• W1964236448 hasConcept C2777546739 @default.
• W1964236448 hasConcept C2778938455 @default.
• W1964236448 hasConcept C2780265364 @default.
• W1964236448 hasConcept C30481170 @default.
• W1964236448 hasConcept C501734568 @default.
• W1964236448 hasConcept C502942594 @default.
• W1964236448 hasConcept C54355233 @default.
• W1964236448 hasConcept C71924100 @default.
• W1964236448 hasConcept C76818968 @default.
• W1964236448 hasConcept C86803240 @default.

• next