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- W1964243249 abstract "The contribution of the spleen in the aetiology and pathogenesis of the anaemia associated with trypanosomiasis was studied in intact and splenectomized mice infected with T. brucei TREU 667. In infected mice which had been splenectomized, the degree of anaemia was slightly increased compared to that in intact mice. However, the red cell survival time, as measured by 51Cr-labelled red cells, was reduced to a similar extent in both groups of infected mice, i.e. from a normal half-life of 6·9 days to 2·9 days. It is suggested that the increased anaemia in the splenectomized mice was largely due to loss of the splenic contribution to erythropoiesis. Retention of the 51Cr-label occurred to a much greater extent in the intact mice, most of the activity being concentrated in the spleen. These results show that the spleen, while an important organ for the sequestration of red cells in trypanosomiasis, is not essential for red cell destruction. Although a reduction in packed cell volume was evident in both groups of mice 7 days after infection, the rate of 51Cr-labelled red cell removal was not increased until at least 12 days after infection; this anomaly was ascribed to haemodilution occurring prior to red cell destruction." @default.
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- W1964243249 date "1977-10-01" @default.
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- W1964243249 title "The effect of splenectomy on anaemia in Trypanosoma brucei infection of mice" @default.
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- W1964243249 doi "https://doi.org/10.1016/0021-9975(77)90063-9" @default.
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