FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964254621> ?p ?o ?g. }

• W1964254621 abstract "In the present study, NMR-based urinary metabonomic profiles resulting from dosing with widely recognized microsomal enzyme inducers were evaluated in male rats. Wistar or Sprague-Dawley rats were dosed daily by oral gavage with phenobarbital (PB; 100 mg/kg), diallyl sulfide (DAS; 500 mg/kg), the investigational compound DMP-904 (150 mg/kg), or beta-naphthoflavone (BNF; 100 mg/kg) for 4 days, and urine was collected daily for analysis. Compounds known to increase cytochrome P450 2B enzymes, including PB, DAS and DMP-904, increased the urinary excretion of gulonic and ascorbic acid in a time-dependent manner, reaching a maximum following 3-4 days of dosing. In contrast, BNF, an agent that induces primarily Cyp1A enzymes, did not increase gulonic or ascorbic acid excretion, despite inducing Cyp1A1 more than 200-fold. Given the metabonomic results, hepatic transcriptional changes in the regulation of ascorbic acid biosynthesis were determined by RT-PCR. All Cyp2B inducers increased hepatic mRNA levels of aldo-keto reductase 1A1, an enzyme that catalyzes the formation of gulonic acid from glucuronate with concurrent decreased expression of both regucalcin (Rgn), the enzyme responsible for conversion of gulonic acid to gulono-1, 4-lactone and gulonolactone oxidase (Gulo), the rate-limiting enzyme in ascorbate biosynthesis. These effects would be expected to increase levels of gulonic acid. In addition, Cyp2B inducers also increased hepatic expression of enzymes regulating ascorbic acid reutilization including glutaredoxin reductase (Glrx2) and thioredoxin reductase (Txnrd1). In contrast, BNF did not effect hepatic expression of any enzyme regulating gulonic or ascorbic acid biosynthesis. Thus, some microsomal enzyme inducers alter transcriptional regulation of ascorbic acid biosynthesis, and these changes are detected by noninvasive metabonomic profiling. However, not all microsomal enzyme inducers appear to alter ascorbic acid metabolism. Finally, the work illustrates how metabonomic results can direct additional studies to determine the biochemical mechanisms underlying changes in urinary metabolite excretion." @default.
• W1964254621 created "2016-06-24" @default.
• W1964254621 creator A5014833273 @default.
• W1964254621 creator A5020417733 @default.
• W1964254621 creator A5025104782 @default.
• W1964254621 creator A5027532565 @default.
• W1964254621 creator A5029178085 @default.
• W1964254621 creator A5079961444 @default.
• W1964254621 creator A5088138942 @default.
• W1964254621 creator A5090091138 @default.
• W1964254621 creator A5043450610 @default.
• W1964254621 date "2009-11-06" @default.
• W1964254621 modified "2023-09-29" @default.
• W1964254621 title "Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling" @default.
• W1964254621 cites W1528169584 @default.
• W1964254621 cites W1797956629 @default.
• W1964254621 cites W186154380 @default.
• W1964254621 cites W1900912696 @default.
• W1964254621 cites W1972086924 @default.
• W1964254621 cites W1976304948 @default.
• W1964254621 cites W1980147496 @default.
• W1964254621 cites W1981260358 @default.
• W1964254621 cites W1994405711 @default.
• W1964254621 cites W2005845442 @default.
• W1964254621 cites W2008646918 @default.
• W1964254621 cites W2018642920 @default.
• W1964254621 cites W2020914439 @default.
• W1964254621 cites W2036373055 @default.
• W1964254621 cites W2038014794 @default.
• W1964254621 cites W2038657917 @default.
• W1964254621 cites W2038976040 @default.
• W1964254621 cites W2042513597 @default.
• W1964254621 cites W2046669628 @default.
• W1964254621 cites W2065016714 @default.
• W1964254621 cites W2077169826 @default.
• W1964254621 cites W2124762431 @default.
• W1964254621 cites W2136178960 @default.
• W1964254621 cites W2150488988 @default.
• W1964254621 cites W2154381726 @default.
• W1964254621 cites W2159436855 @default.
• W1964254621 cites W2161588172 @default.
• W1964254621 cites W2163617578 @default.
• W1964254621 cites W2166185840 @default.
• W1964254621 doi "https://doi.org/10.1002/mrc.2503" @default.
• W1964254621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19768707" @default.
• W1964254621 hasPublicationYear "2009" @default.
• W1964254621 type Work @default.
• W1964254621 sameAs 1964254621 @default.
• W1964254621 citedByCount "11" @default.
• W1964254621 countsByYear W19642546212012 @default.
• W1964254621 countsByYear W19642546212013 @default.
• W1964254621 countsByYear W19642546212014 @default.
• W1964254621 countsByYear W19642546212015 @default.
• W1964254621 countsByYear W19642546212017 @default.
• W1964254621 countsByYear W19642546212023 @default.
• W1964254621 crossrefType "journal-article" @default.
• W1964254621 hasAuthorship W1964254621A5014833273 @default.
• W1964254621 hasAuthorship W1964254621A5020417733 @default.
• W1964254621 hasAuthorship W1964254621A5025104782 @default.
• W1964254621 hasAuthorship W1964254621A5027532565 @default.
• W1964254621 hasAuthorship W1964254621A5029178085 @default.
• W1964254621 hasAuthorship W1964254621A5043450610 @default.
• W1964254621 hasAuthorship W1964254621A5079961444 @default.
• W1964254621 hasAuthorship W1964254621A5088138942 @default.
• W1964254621 hasAuthorship W1964254621A5090091138 @default.
• W1964254621 hasConcept C10146269 @default.
• W1964254621 hasConcept C132154277 @default.
• W1964254621 hasConcept C134651460 @default.
• W1964254621 hasConcept C181199279 @default.
• W1964254621 hasConcept C185592680 @default.
• W1964254621 hasConcept C2986274086 @default.
• W1964254621 hasConcept C31903555 @default.
• W1964254621 hasConcept C526171541 @default.
• W1964254621 hasConcept C55493867 @default.
• W1964254621 hasConcept C62231903 @default.
• W1964254621 hasConceptScore W1964254621C10146269 @default.
• W1964254621 hasConceptScore W1964254621C132154277 @default.
• W1964254621 hasConceptScore W1964254621C134651460 @default.
• W1964254621 hasConceptScore W1964254621C181199279 @default.
• W1964254621 hasConceptScore W1964254621C185592680 @default.
• W1964254621 hasConceptScore W1964254621C2986274086 @default.
• W1964254621 hasConceptScore W1964254621C31903555 @default.
• W1964254621 hasConceptScore W1964254621C526171541 @default.
• W1964254621 hasConceptScore W1964254621C55493867 @default.
• W1964254621 hasConceptScore W1964254621C62231903 @default.
• W1964254621 hasIssue "S1" @default.
• W1964254621 hasLocation W19642546211 @default.
• W1964254621 hasLocation W19642546212 @default.
• W1964254621 hasOpenAccess W1964254621 @default.
• W1964254621 hasPrimaryLocation W19642546211 @default.
• W1964254621 hasRelatedWork W1581350964 @default.
• W1964254621 hasRelatedWork W1981399765 @default.
• W1964254621 hasRelatedWork W2013750836 @default.
• W1964254621 hasRelatedWork W2022924400 @default.
• W1964254621 hasRelatedWork W2043151771 @default.
• W1964254621 hasRelatedWork W2056838873 @default.
• W1964254621 hasRelatedWork W2071806336 @default.
• W1964254621 hasRelatedWork W2203878617 @default.
• W1964254621 hasRelatedWork W2419414102 @default.
• W1964254621 hasRelatedWork W966738943 @default.

• next