Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964260115> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1964260115 endingPage "459" @default.
- W1964260115 startingPage "449" @default.
- W1964260115 abstract "We have devised a new process for modifying heat-labile allergens, which employs a sequential two-step incubation at temperatures of 10 degree C and 30 degree to 32 degree C. This process was found to produce effective ragweed allergoids with low allergenicity and good immunogenicity, which makes them useful for the therapy of allergic humans. Modification with formaldehyde produced derivatives (formallergoids) that were about 10-fold less allergenic in allergic humans (as measured by leukocyte histamine-release assay), and similarly or more immunogenic in guinea pigs, than glutaraldehyde-modified allergens (glutarallergoids). Further analysis by RAST inhibition showed that a ragweed formallergoid was sixfold less reactive than a glutarallergoid with a pool of human IgE antibodies. However, the formallergoid had retained the ability to induce a wide array of antibodies against native ragweed antigens, since rabbit anti-formallergoid serum was able to recognize at least 12 different ragweed antigens, including AgE. Gel-filtration experiments showed that both the formallergoid and glutarallergoid materials contained polymers having apparent molecular weights distributed around 260,000 and 230,000 daltons, respectively (approximate range 30,000 to 900,000 daltons). Our studies provide the immunochemical basis for the use of these allergoids in the therapy of allergic humans." @default.
- W1964260115 created "2016-06-24" @default.
- W1964260115 creator A5004699609 @default.
- W1964260115 creator A5049027996 @default.
- W1964260115 creator A5050786625 @default.
- W1964260115 creator A5054711386 @default.
- W1964260115 date "1981-12-01" @default.
- W1964260115 modified "2023-10-18" @default.
- W1964260115 title "Studies on allergoids from naturally occurring allergens III. Preparation of ragweed pollen allergoids by aldehyde modification in two steps" @default.
- W1964260115 cites W1827139313 @default.
- W1964260115 cites W1975952376 @default.
- W1964260115 cites W1977987716 @default.
- W1964260115 cites W1981619228 @default.
- W1964260115 cites W1985570951 @default.
- W1964260115 cites W2007930766 @default.
- W1964260115 cites W2009280170 @default.
- W1964260115 cites W2020545328 @default.
- W1964260115 cites W2055330998 @default.
- W1964260115 cites W2056837549 @default.
- W1964260115 cites W2065174822 @default.
- W1964260115 cites W2071338557 @default.
- W1964260115 cites W2080656627 @default.
- W1964260115 cites W2087610715 @default.
- W1964260115 cites W2418776774 @default.
- W1964260115 cites W2614316866 @default.
- W1964260115 cites W3161189811 @default.
- W1964260115 doi "https://doi.org/10.1016/0091-6749(81)90199-8" @default.
- W1964260115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6171586" @default.
- W1964260115 hasPublicationYear "1981" @default.
- W1964260115 type Work @default.
- W1964260115 sameAs 1964260115 @default.
- W1964260115 citedByCount "60" @default.
- W1964260115 countsByYear W19642601152012 @default.
- W1964260115 countsByYear W19642601152014 @default.
- W1964260115 countsByYear W19642601152015 @default.
- W1964260115 countsByYear W19642601152017 @default.
- W1964260115 countsByYear W19642601152019 @default.
- W1964260115 countsByYear W19642601152020 @default.
- W1964260115 crossrefType "journal-article" @default.
- W1964260115 hasAuthorship W1964260115A5004699609 @default.
- W1964260115 hasAuthorship W1964260115A5049027996 @default.
- W1964260115 hasAuthorship W1964260115A5050786625 @default.
- W1964260115 hasAuthorship W1964260115A5054711386 @default.
- W1964260115 hasConcept C1122143 @default.
- W1964260115 hasConcept C141105273 @default.
- W1964260115 hasConcept C147483822 @default.
- W1964260115 hasConcept C159654299 @default.
- W1964260115 hasConcept C185592680 @default.
- W1964260115 hasConcept C203014093 @default.
- W1964260115 hasConcept C207480886 @default.
- W1964260115 hasConcept C2777529624 @default.
- W1964260115 hasConcept C2779026604 @default.
- W1964260115 hasConcept C2780510475 @default.
- W1964260115 hasConcept C2780868878 @default.
- W1964260115 hasConcept C2780931586 @default.
- W1964260115 hasConcept C43617362 @default.
- W1964260115 hasConcept C86803240 @default.
- W1964260115 hasConcept C98274493 @default.
- W1964260115 hasConceptScore W1964260115C1122143 @default.
- W1964260115 hasConceptScore W1964260115C141105273 @default.
- W1964260115 hasConceptScore W1964260115C147483822 @default.
- W1964260115 hasConceptScore W1964260115C159654299 @default.
- W1964260115 hasConceptScore W1964260115C185592680 @default.
- W1964260115 hasConceptScore W1964260115C203014093 @default.
- W1964260115 hasConceptScore W1964260115C207480886 @default.
- W1964260115 hasConceptScore W1964260115C2777529624 @default.
- W1964260115 hasConceptScore W1964260115C2779026604 @default.
- W1964260115 hasConceptScore W1964260115C2780510475 @default.
- W1964260115 hasConceptScore W1964260115C2780868878 @default.
- W1964260115 hasConceptScore W1964260115C2780931586 @default.
- W1964260115 hasConceptScore W1964260115C43617362 @default.
- W1964260115 hasConceptScore W1964260115C86803240 @default.
- W1964260115 hasConceptScore W1964260115C98274493 @default.
- W1964260115 hasIssue "6" @default.
- W1964260115 hasLocation W19642601151 @default.
- W1964260115 hasLocation W19642601152 @default.
- W1964260115 hasOpenAccess W1964260115 @default.
- W1964260115 hasPrimaryLocation W19642601151 @default.
- W1964260115 hasRelatedWork W104273242 @default.
- W1964260115 hasRelatedWork W1993765398 @default.
- W1964260115 hasRelatedWork W2006447889 @default.
- W1964260115 hasRelatedWork W2019808322 @default.
- W1964260115 hasRelatedWork W2035986307 @default.
- W1964260115 hasRelatedWork W2069904559 @default.
- W1964260115 hasRelatedWork W2414954666 @default.
- W1964260115 hasRelatedWork W27400869 @default.
- W1964260115 hasRelatedWork W4283808193 @default.
- W1964260115 hasRelatedWork W4309786682 @default.
- W1964260115 hasVolume "68" @default.
- W1964260115 isParatext "false" @default.
- W1964260115 isRetracted "false" @default.
- W1964260115 magId "1964260115" @default.
- W1964260115 workType "article" @default.