FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964264712> ?p ?o ?g. }

• W1964264712 endingPage "476" @default.
• W1964264712 startingPage "471" @default.
• W1964264712 abstract "Decreases in hepatocyte NAD+ produced by ethanol are only partially explained by the increased conversion of NAD+ to NADH and NADP+. The purpose of this study was to determine whether a mechanism for the ethanol-induced decrease in NAD+ is its increased use in ADP-ribosylation. Exposure of hepatocytes in culture for 2 hr to 100 mmol/L ethanol increased the incorporation of 14C-ribose from prelabeled NAD+ into 14C-ribosylated proteins. Poly (ADP-ribose) polymerase activity was increased by exposure of isolated hepatocytes to 100 mmol/L ethanol for 10 min. In hepatocyte culture, increases in poly (ADP-ribose) polymerase were not detected after exposure to 100 mmol/L ethanol for 10 min or 2 hr but rather occurred at 24 hr. Ethanol exposure of hepatocytes in culture for 2 hr, however, decreased the Km for NAD+ of poly (ADP-ribose) polymerase. Both nicotinamide and 5-aminobenzamide, which are inhibitors of poly (ADP-ribose) polymerase, prevented the decrease in NAD+ produced by 2-hr exposure of hepatocytes in culture to 100 mmol/L ethanol. The effect of ethanol in decreasing DNA synthesis on days 3 and 4 of culture was not reversed by the inhibitors of poly (ADP-ribose) polymerase. These results indicate that increased ADP-ribosylation of hepatocyte proteins is a mechanism for the effect of ethanol in decreasing NAD+." @default.
• W1964264712 created "2016-06-24" @default.
• W1964264712 creator A5002831535 @default.
• W1964264712 creator A5022425182 @default.
• W1964264712 creator A5032283469 @default.
• W1964264712 creator A5035012119 @default.
• W1964264712 date "1992-03-01" @default.
• W1964264712 modified "2023-10-16" @default.
• W1964264712 title "Ethanol enhances ADP-ribosylation of protein in rat hepatocytes" @default.
• W1964264712 cites W123340411 @default.
• W1964264712 cites W1529304947 @default.
• W1964264712 cites W1531808272 @default.
• W1964264712 cites W1535160845 @default.
• W1964264712 cites W1546755706 @default.
• W1964264712 cites W1565037888 @default.
• W1964264712 cites W1597879805 @default.
• W1964264712 cites W1604712238 @default.
• W1964264712 cites W1605583574 @default.
• W1964264712 cites W170198858 @default.
• W1964264712 cites W1775749144 @default.
• W1964264712 cites W17970236 @default.
• W1964264712 cites W1984770312 @default.
• W1964264712 cites W1985333335 @default.
• W1964264712 cites W1986824378 @default.
• W1964264712 cites W1990210725 @default.
• W1964264712 cites W1998843941 @default.
• W1964264712 cites W2002603625 @default.
• W1964264712 cites W2007848694 @default.
• W1964264712 cites W2013605216 @default.
• W1964264712 cites W2017088445 @default.
• W1964264712 cites W2023326304 @default.
• W1964264712 cites W2024806073 @default.
• W1964264712 cites W2025357993 @default.
• W1964264712 cites W2031362233 @default.
• W1964264712 cites W2033172595 @default.
• W1964264712 cites W2046964199 @default.
• W1964264712 cites W2066397124 @default.
• W1964264712 cites W2068582203 @default.
• W1964264712 cites W206921065 @default.
• W1964264712 cites W2086389710 @default.
• W1964264712 cites W2268197518 @default.
• W1964264712 cites W2325814368 @default.
• W1964264712 cites W2581340747 @default.
• W1964264712 cites W2910968213 @default.
• W1964264712 cites W4252215306 @default.
• W1964264712 doi "https://doi.org/10.1002/hep.1840150320" @default.
• W1964264712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1544629" @default.
• W1964264712 hasPublicationYear "1992" @default.
• W1964264712 type Work @default.
• W1964264712 sameAs 1964264712 @default.
• W1964264712 citedByCount "8" @default.
• W1964264712 countsByYear W19642647122015 @default.
• W1964264712 countsByYear W19642647122016 @default.
• W1964264712 countsByYear W19642647122017 @default.
• W1964264712 crossrefType "journal-article" @default.
• W1964264712 hasAuthorship W1964264712A5002831535 @default.
• W1964264712 hasAuthorship W1964264712A5022425182 @default.
• W1964264712 hasAuthorship W1964264712A5032283469 @default.
• W1964264712 hasAuthorship W1964264712A5035012119 @default.
• W1964264712 hasBestOaLocation W19642647121 @default.
• W1964264712 hasConcept C153911025 @default.
• W1964264712 hasConcept C181199279 @default.
• W1964264712 hasConcept C182979987 @default.
• W1964264712 hasConcept C185592680 @default.
• W1964264712 hasConcept C202751555 @default.
• W1964264712 hasConcept C2776200302 @default.
• W1964264712 hasConcept C2779728014 @default.
• W1964264712 hasConcept C2780161600 @default.
• W1964264712 hasConcept C45510557 @default.
• W1964264712 hasConcept C55493867 @default.
• W1964264712 hasConcept C75520062 @default.
• W1964264712 hasConcept C82381507 @default.
• W1964264712 hasConcept C86803240 @default.
• W1964264712 hasConceptScore W1964264712C153911025 @default.
• W1964264712 hasConceptScore W1964264712C181199279 @default.
• W1964264712 hasConceptScore W1964264712C182979987 @default.
• W1964264712 hasConceptScore W1964264712C185592680 @default.
• W1964264712 hasConceptScore W1964264712C202751555 @default.
• W1964264712 hasConceptScore W1964264712C2776200302 @default.
• W1964264712 hasConceptScore W1964264712C2779728014 @default.
• W1964264712 hasConceptScore W1964264712C2780161600 @default.
• W1964264712 hasConceptScore W1964264712C45510557 @default.
• W1964264712 hasConceptScore W1964264712C55493867 @default.
• W1964264712 hasConceptScore W1964264712C75520062 @default.
• W1964264712 hasConceptScore W1964264712C82381507 @default.
• W1964264712 hasConceptScore W1964264712C86803240 @default.
• W1964264712 hasIssue "3" @default.
• W1964264712 hasLocation W19642647121 @default.
• W1964264712 hasLocation W19642647122 @default.
• W1964264712 hasOpenAccess W1964264712 @default.
• W1964264712 hasPrimaryLocation W19642647121 @default.
• W1964264712 hasRelatedWork W103515559 @default.
• W1964264712 hasRelatedWork W184207458 @default.
• W1964264712 hasRelatedWork W1964264712 @default.
• W1964264712 hasRelatedWork W1981510143 @default.
• W1964264712 hasRelatedWork W2013605216 @default.
• W1964264712 hasRelatedWork W2016517525 @default.
• W1964264712 hasRelatedWork W2021766920 @default.

• next