FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964265213> ?p ?o ?g. }

• W1964265213 endingPage "38" @default.
• W1964265213 startingPage "27" @default.
• W1964265213 abstract "In addition to functioning as an essential nutrient for cellular growth and maintenance, nicotinamide also may be an attractive therapeutic agent with efficacy demonstrated against free radical ischemic programmed cell death (PCD). Yet, the cellular mechanisms that mediate cellular PCD, as well as protection by nicotinamide, are considered to require further definition. In primary rat hippocampal neurons and rat cerebrovascular endothelial cells (ECs), cellular injury was determined through trypan blue dye exclusion, externalization of membrane phosphatidylserine (PS) residues, and activation of the mitogen-activated protein kinase p38 through Western blot analysis. Nicotinamide was without cellular toxicity at concentrations lower than 50 mM in both neuronal and EC populations. Exposure to either anoxia or the nitric oxide (NO) donors sodium nitroprusside and NOC-9 significantly decreased neuronal and EC survival from approximately 85% to 38% and increased membrane PS exposure from approximately 10% to 80% over a 24-hour period. Pretreatment with nicotinamide (12.5 mM) prevented anoxic and NO cytodegeneration by significantly increasing survival and decreasing membrane PS expression. Protection by nicotinamide in both neurons and ECs appeared to be independent and downstream from p38 activation. Further investigations that define the cellular and molecular mechanisms employed by the nutrient nicotinamide may provide greater insight into the potential therapeutic targets that determine neuronal and vascular injury." @default.
• W1964265213 created "2016-06-24" @default.
• W1964265213 creator A5000415542 @default.
• W1964265213 creator A5017239247 @default.
• W1964265213 creator A5057464586 @default.
• W1964265213 date "2001-03-01" @default.
• W1964265213 modified "2023-10-18" @default.
• W1964265213 title "Nicotinamide: A Nutritional Supplement that Provides Protection Against Neuronal and Vascular Injury" @default.
• W1964265213 cites W124719744 @default.
• W1964265213 cites W130179140 @default.
• W1964265213 cites W1950821376 @default.
• W1964265213 cites W1965876571 @default.
• W1964265213 cites W1972788010 @default.
• W1964265213 cites W1974198922 @default.
• W1964265213 cites W1981955278 @default.
• W1964265213 cites W1982868475 @default.
• W1964265213 cites W1991500856 @default.
• W1964265213 cites W1995862213 @default.
• W1964265213 cites W2017326736 @default.
• W1964265213 cites W2021390728 @default.
• W1964265213 cites W2022185876 @default.
• W1964265213 cites W2024876727 @default.
• W1964265213 cites W2029083682 @default.
• W1964265213 cites W2030350648 @default.
• W1964265213 cites W2033740616 @default.
• W1964265213 cites W2046577904 @default.
• W1964265213 cites W2053444852 @default.
• W1964265213 cites W2067822361 @default.
• W1964265213 cites W2068313599 @default.
• W1964265213 cites W2074880138 @default.
• W1964265213 cites W2075660487 @default.
• W1964265213 cites W2078484961 @default.
• W1964265213 cites W2081104499 @default.
• W1964265213 cites W2090089146 @default.
• W1964265213 cites W2108587622 @default.
• W1964265213 cites W2112173647 @default.
• W1964265213 cites W2124968202 @default.
• W1964265213 cites W2124998768 @default.
• W1964265213 cites W2131523916 @default.
• W1964265213 cites W2143944971 @default.
• W1964265213 cites W2328105170 @default.
• W1964265213 cites W40833958 @default.
• W1964265213 cites W4255929391 @default.
• W1964265213 doi "https://doi.org/10.1089/10966200152053686" @default.
• W1964265213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12639285" @default.
• W1964265213 hasPublicationYear "2001" @default.
• W1964265213 type Work @default.
• W1964265213 sameAs 1964265213 @default.
• W1964265213 citedByCount "31" @default.
• W1964265213 countsByYear W19642652132012 @default.
• W1964265213 countsByYear W19642652132015 @default.
• W1964265213 countsByYear W19642652132018 @default.
• W1964265213 countsByYear W19642652132019 @default.
• W1964265213 countsByYear W19642652132020 @default.
• W1964265213 countsByYear W19642652132021 @default.
• W1964265213 countsByYear W19642652132023 @default.
• W1964265213 crossrefType "journal-article" @default.
• W1964265213 hasAuthorship W1964265213A5000415542 @default.
• W1964265213 hasAuthorship W1964265213A5017239247 @default.
• W1964265213 hasAuthorship W1964265213A5057464586 @default.
• W1964265213 hasConcept C104317684 @default.
• W1964265213 hasConcept C181199279 @default.
• W1964265213 hasConcept C184235292 @default.
• W1964265213 hasConcept C185592680 @default.
• W1964265213 hasConcept C190283241 @default.
• W1964265213 hasConcept C2776415932 @default.
• W1964265213 hasConcept C2779728014 @default.
• W1964265213 hasConcept C2780070996 @default.
• W1964265213 hasConcept C31573885 @default.
• W1964265213 hasConcept C51551487 @default.
• W1964265213 hasConcept C55493867 @default.
• W1964265213 hasConcept C86803240 @default.
• W1964265213 hasConcept C95444343 @default.
• W1964265213 hasConcept C97029542 @default.
• W1964265213 hasConcept C98274493 @default.
• W1964265213 hasConceptScore W1964265213C104317684 @default.
• W1964265213 hasConceptScore W1964265213C181199279 @default.
• W1964265213 hasConceptScore W1964265213C184235292 @default.
• W1964265213 hasConceptScore W1964265213C185592680 @default.
• W1964265213 hasConceptScore W1964265213C190283241 @default.
• W1964265213 hasConceptScore W1964265213C2776415932 @default.
• W1964265213 hasConceptScore W1964265213C2779728014 @default.
• W1964265213 hasConceptScore W1964265213C2780070996 @default.
• W1964265213 hasConceptScore W1964265213C31573885 @default.
• W1964265213 hasConceptScore W1964265213C51551487 @default.
• W1964265213 hasConceptScore W1964265213C55493867 @default.
• W1964265213 hasConceptScore W1964265213C86803240 @default.
• W1964265213 hasConceptScore W1964265213C95444343 @default.
• W1964265213 hasConceptScore W1964265213C97029542 @default.
• W1964265213 hasConceptScore W1964265213C98274493 @default.
• W1964265213 hasIssue "1" @default.
• W1964265213 hasLocation W19642652131 @default.
• W1964265213 hasLocation W19642652132 @default.
• W1964265213 hasOpenAccess W1964265213 @default.
• W1964265213 hasPrimaryLocation W19642652131 @default.
• W1964265213 hasRelatedWork W1987695408 @default.
• W1964265213 hasRelatedWork W2021567803 @default.
• W1964265213 hasRelatedWork W2093995961 @default.

• next