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• W1964281010 endingPage "2267" @default.
• W1964281010 startingPage "2259" @default.
• W1964281010 abstract "Abstract The recent discovery of action potentials with a Ca component in pars intermedia cells raised the question whether voltage-dependent Ca 2+ influx participates in stimulus-secretion coupling in these cells. To test this, a study was made of the effects of a depolarizing concentration of K + on melanocyte-stimulating hormone (MSH) output from isolated pars intermedia cells of rats and mice obtained by tissue disaggregation and maintained in culture for periods ranging from 2 h to 10 days. The cells were placed in a column which was perfused thereby permitting continuous monitoring of MSH output. The cells secreted MSH promptly upon exposure to 50 m M K + and this effect was abolished when Ca 2+ was omitted or when Co 2+ was added to block Ca channels. It is concluded that activation of voltage-dependent Ca channels in pars intermedia cells allows influx of Ca ions that provides an adequate stimulus for MSH secretion. Furthermore, inhibitory effects of Ca 2+ lack and of Co 2+ addition on basal MSH output suggest the operation of such a Ca-dependent mechanism during spontaneous secretory activity. Secretory responses to high [K + ], although intense, were brief and waned rapidly during continuous exposure to K + . Experiments showing that Ca 2+ fails to elicit secretion when introduced with a delay of several minutes after exposure to high [K + ] indicate that the transience of the response is due to inactivation of voltage-dependent Ca channels. The brevity of the response of the isolated pars intermedia cells to high [K + ] may explain, at least in part, why stimulant effects of excess K + have not been seen previously, or in the present experiments in intact neurointermediate lobes of rats. When the much smaller, and seemingly more favorable, neurointermediate lobes of mice were used, K + elicited a Ca-dependent secretion of MSH comparable with that seen in the isolated cells. The demonstration that pars intermedia cells respond directly to a depolarizing stimulus by secreting MSH encourages the view that electrical activity in these cells is involved in the regulation of secretion." @default.
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• W1964281010 date "1981-11-01" @default.
• W1964281010 modified "2023-10-14" @default.
• W1964281010 title "Potassium-induced secretion of melanocytestimulating hormone from isolated pars intermedia cells signals participation of voltage-dependent calcium channels in stimulus-secretion coupling" @default.
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• W1964281010 doi "https://doi.org/10.1016/0306-4522(81)90015-4" @default.
• W1964281010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6276813" @default.
• W1964281010 hasPublicationYear "1981" @default.
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