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- W1964293225 abstract "Temperature affects a host of biological processes, one of which is the conduction velocity of action potentials (AP). The velocity-temperature profile of APs has remained remarkably conserved across excitable animal and plant cells. Herein, we will not analyze this behavior in terms of temperature sensitivities of single molecules (e.g., ion channels), but rather we present a phenomenological thermodynamic interpretation. By assuming that APs are acoustic phenomena, one arrives at testable predictions about the temperature-dependence of the macroscopic material properties of the excitable cell membrane. These material properties set constraints on the excitability of a cell membrane and allow us to hypothesize about its typical relaxation timescales. The presented approach—by virtue of its thermodynamic nature—is by no means limited to temperature. It applies equally well to all thermodynamic variables (e.g., mechanical stretch, pH, ion concentrations, etc.) and to underline this argument we discuss some implications and predictions for sensory physiology." @default.
- W1964293225 created "2016-06-24" @default.
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- W1964293225 date "2013-11-09" @default.
- W1964293225 modified "2023-10-14" @default.
- W1964293225 title "Temperature and excitable cells" @default.
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- W1964293225 doi "https://doi.org/10.4161/cib.26730" @default.
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