FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964305055> ?p ?o ?g. }

• W1964305055 endingPage "936" @default.
• W1964305055 startingPage "927" @default.
• W1964305055 abstract "To determine whether the activation of nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase and the increase of superoxide anion production by angiotensin II is dependent upon the activation of the ERK-MAPK pathway.Hypertension was induced in Sprague-Dawley rats by infusing angiotensin II (200 ng/kg per min) through osmotic pumps for 12 days. The effects of treatments including an angiotensin II type 1 (AT(1)) blocker losartan (20 mg/kg per day), a tyrosine kinase inhibitor genistein (1.6 microg/kg per min), a specific ERK-MAPK inhibitor, PD98059 (2 mg/kg per day) and an antioxidant alpha-lipoic acid (500 mg/kg of chow) were evaluated during angiotensin infusion. The aortic superoxide anion production, the ERK-MAPK pathway activity and the systolic blood pressure (SBP), were measured following those treatments.Increases in the concentration of the superoxide anion (1622 to 3719 cpm), in NAD(P)H activity (107%) and in the ERK-MAPK activity (3.6-fold) in the aorta as well as a rise in the arterial pressure (136 to 184 mmHg) were observed 12 days after initiating the treatments (P < 0.05). When the angiotensin-treated rats were treated either with losartan, genistein, PD98059 or alpha-lipoic acid, increases in superoxide anion production, in NAD(P)H oxidase activity, in ERK-MAPK activity and in blood pressure were attenuated. A correlation between the superoxide anion production and the ERK-MAPK activity was also observed.The present study suggests that the NAD(P)H-dependent increase of the superoxide anion production in the vascular tissue following a treatment with angiotensin II is dependent on the activation of the ERK-MAPK pathway." @default.
• W1964305055 created "2016-06-24" @default.
• W1964305055 creator A5011395719 @default.
• W1964305055 creator A5012018806 @default.
• W1964305055 creator A5020529417 @default.
• W1964305055 creator A5087711323 @default.
• W1964305055 date "2003-05-01" @default.
• W1964305055 modified "2023-10-17" @default.
• W1964305055 title "NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells" @default.
• W1964305055 cites W1497341558 @default.
• W1964305055 cites W1551392207 @default.
• W1964305055 cites W1963652918 @default.
• W1964305055 cites W1964247319 @default.
• W1964305055 cites W1974372019 @default.
• W1964305055 cites W1976555160 @default.
• W1964305055 cites W1979356762 @default.
• W1964305055 cites W1987162287 @default.
• W1964305055 cites W1990111257 @default.
• W1964305055 cites W2000709175 @default.
• W1964305055 cites W2000756775 @default.
• W1964305055 cites W2003865622 @default.
• W1964305055 cites W2008085837 @default.
• W1964305055 cites W2009220666 @default.
• W1964305055 cites W2015589563 @default.
• W1964305055 cites W2039527984 @default.
• W1964305055 cites W2039531860 @default.
• W1964305055 cites W2044443940 @default.
• W1964305055 cites W2044635516 @default.
• W1964305055 cites W2045285578 @default.
• W1964305055 cites W2045876343 @default.
• W1964305055 cites W2055635848 @default.
• W1964305055 cites W2056429367 @default.
• W1964305055 cites W2060052300 @default.
• W1964305055 cites W2074623822 @default.
• W1964305055 cites W2081394289 @default.
• W1964305055 cites W2101785330 @default.
• W1964305055 cites W2102140304 @default.
• W1964305055 cites W2110182057 @default.
• W1964305055 cites W2110827050 @default.
• W1964305055 cites W2116133877 @default.
• W1964305055 cites W2129301938 @default.
• W1964305055 cites W2129531515 @default.
• W1964305055 cites W2131670555 @default.
• W1964305055 cites W2132039169 @default.
• W1964305055 cites W2135633069 @default.
• W1964305055 cites W2144850874 @default.
• W1964305055 cites W2155866739 @default.
• W1964305055 cites W2159172002 @default.
• W1964305055 cites W2159984465 @default.
• W1964305055 cites W2162668341 @default.
• W1964305055 cites W2163295962 @default.
• W1964305055 cites W2170794217 @default.
• W1964305055 cites W2314858845 @default.
• W1964305055 cites W2322391192 @default.
• W1964305055 cites W4245934347 @default.
• W1964305055 cites W4254247752 @default.
• W1964305055 doi "https://doi.org/10.1097/00004872-200305000-00017" @default.
• W1964305055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12714867" @default.
• W1964305055 hasPublicationYear "2003" @default.
• W1964305055 type Work @default.
• W1964305055 sameAs 1964305055 @default.
• W1964305055 citedByCount "61" @default.
• W1964305055 countsByYear W19643050552012 @default.
• W1964305055 countsByYear W19643050552013 @default.
• W1964305055 countsByYear W19643050552014 @default.
• W1964305055 countsByYear W19643050552015 @default.
• W1964305055 countsByYear W19643050552016 @default.
• W1964305055 countsByYear W19643050552017 @default.
• W1964305055 countsByYear W19643050552018 @default.
• W1964305055 countsByYear W19643050552020 @default.
• W1964305055 countsByYear W19643050552021 @default.
• W1964305055 crossrefType "journal-article" @default.
• W1964305055 hasAuthorship W1964305055A5011395719 @default.
• W1964305055 hasAuthorship W1964305055A5012018806 @default.
• W1964305055 hasAuthorship W1964305055A5020529417 @default.
• W1964305055 hasAuthorship W1964305055A5087711323 @default.
• W1964305055 hasConcept C126322002 @default.
• W1964305055 hasConcept C134018914 @default.
• W1964305055 hasConcept C181199279 @default.
• W1964305055 hasConcept C184235292 @default.
• W1964305055 hasConcept C185592680 @default.
• W1964305055 hasConcept C198710026 @default.
• W1964305055 hasConcept C2776151105 @default.
• W1964305055 hasConcept C2777989768 @default.
• W1964305055 hasConcept C2779719074 @default.
• W1964305055 hasConcept C2780288358 @default.
• W1964305055 hasConcept C2780795997 @default.
• W1964305055 hasConcept C2781252958 @default.
• W1964305055 hasConcept C2908929049 @default.
• W1964305055 hasConcept C38485361 @default.
• W1964305055 hasConcept C55493867 @default.
• W1964305055 hasConcept C57074206 @default.
• W1964305055 hasConcept C71924100 @default.
• W1964305055 hasConcept C84393581 @default.
• W1964305055 hasConcept C98274493 @default.
• W1964305055 hasConceptScore W1964305055C126322002 @default.
• W1964305055 hasConceptScore W1964305055C134018914 @default.
• W1964305055 hasConceptScore W1964305055C181199279 @default.

• next