FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964310011> ?p ?o ?g. }

• W1964310011 endingPage "5323" @default.
• W1964310011 startingPage "5313" @default.
• W1964310011 abstract "ABSTRACT DC-SIGN, a lectin expressed on dendritic cell and macrophage subsets, binds to human immunodeficiency virus Env glycoproteins, allowing capture of viral particles. Captured virions either infect target cells or are efficiently transmitted to lymphocytes. Cellular mechanisms underlying the effects of DC-SIGN remain poorly understood. Here we have analyzed the effects of DC-SIGN on viral entry and on syncytium formation induced by Env glycoproteins. The lectin enhanced susceptibility to viral infection and dramatically increased virion internalization. Captured virions accumulated in the vesicular pathway, and their access to the cytosol was altered. Strikingly, the presence of DC-SIGN on target cells inhibited their ability to form syncytia with Env-expressing cells. However, increasing CD4 surface levels on target cells alleviated this inhibitory effect of DC-SIGN. Moreover, the potency of the viral fusion inhibitor T-20 was not affected in DC-SIGN-expressing cells. Altogether, our results indicate that DC-SIGN exerts subtle and complex effects during early steps of HIV type 1 replication. DC-SIGN facilitates capture and accumulation of viral particles in a vesicular compartment and inhibits viral fusion. Competition between CD4 and DC-SIGN for Env binding likely affects virus access to the cytosol and syncytium formation." @default.
• W1964310011 created "2016-06-24" @default.
• W1964310011 creator A5021416323 @default.
• W1964310011 creator A5032425111 @default.
• W1964310011 creator A5036210497 @default.
• W1964310011 creator A5055664477 @default.
• W1964310011 creator A5085865782 @default.
• W1964310011 date "2003-05-01" @default.
• W1964310011 modified "2023-10-09" @default.
• W1964310011 title "Inhibition of Human Immunodeficiency Virus Type 1 Env-Mediated Fusion by DC-SIGN" @default.
• W1964310011 cites W108460990 @default.
• W1964310011 cites W1516991153 @default.
• W1964310011 cites W1562621350 @default.
• W1964310011 cites W1952047011 @default.
• W1964310011 cites W1966778178 @default.
• W1964310011 cites W1972932827 @default.
• W1964310011 cites W1980272197 @default.
• W1964310011 cites W1987046764 @default.
• W1964310011 cites W1990283625 @default.
• W1964310011 cites W1990623781 @default.
• W1964310011 cites W1991690755 @default.
• W1964310011 cites W1995045410 @default.
• W1964310011 cites W2006370225 @default.
• W1964310011 cites W2013729472 @default.
• W1964310011 cites W2016475905 @default.
• W1964310011 cites W2016861362 @default.
• W1964310011 cites W2023270608 @default.
• W1964310011 cites W2027437965 @default.
• W1964310011 cites W2033757712 @default.
• W1964310011 cites W2039028257 @default.
• W1964310011 cites W2044040790 @default.
• W1964310011 cites W2051073016 @default.
• W1964310011 cites W2062561488 @default.
• W1964310011 cites W2093828185 @default.
• W1964310011 cites W2097267947 @default.
• W1964310011 cites W2097295476 @default.
• W1964310011 cites W2112478558 @default.
• W1964310011 cites W2118364979 @default.
• W1964310011 cites W2125091383 @default.
• W1964310011 cites W2127815795 @default.
• W1964310011 cites W2127954824 @default.
• W1964310011 cites W2145289892 @default.
• W1964310011 cites W2145508988 @default.
• W1964310011 cites W2146978346 @default.
• W1964310011 cites W2151864174 @default.
• W1964310011 cites W2156643487 @default.
• W1964310011 cites W2163570329 @default.
• W1964310011 doi "https://doi.org/10.1128/jvi.77.9.5313-5323.2003" @default.
• W1964310011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/153976" @default.
• W1964310011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12692233" @default.
• W1964310011 hasPublicationYear "2003" @default.
• W1964310011 type Work @default.
• W1964310011 sameAs 1964310011 @default.
• W1964310011 citedByCount "39" @default.
• W1964310011 countsByYear W19643100112012 @default.
• W1964310011 countsByYear W19643100112013 @default.
• W1964310011 countsByYear W19643100112015 @default.
• W1964310011 countsByYear W19643100112017 @default.
• W1964310011 countsByYear W19643100112018 @default.
• W1964310011 countsByYear W19643100112019 @default.
• W1964310011 countsByYear W19643100112023 @default.
• W1964310011 crossrefType "journal-article" @default.
• W1964310011 hasAuthorship W1964310011A5021416323 @default.
• W1964310011 hasAuthorship W1964310011A5032425111 @default.
• W1964310011 hasAuthorship W1964310011A5036210497 @default.
• W1964310011 hasAuthorship W1964310011A5055664477 @default.
• W1964310011 hasAuthorship W1964310011A5085865782 @default.
• W1964310011 hasBestOaLocation W19643100112 @default.
• W1964310011 hasConcept C103038307 @default.
• W1964310011 hasConcept C106257327 @default.
• W1964310011 hasConcept C108625454 @default.
• W1964310011 hasConcept C139770010 @default.
• W1964310011 hasConcept C140704245 @default.
• W1964310011 hasConcept C147483822 @default.
• W1964310011 hasConcept C1491633281 @default.
• W1964310011 hasConcept C153911025 @default.
• W1964310011 hasConcept C159047783 @default.
• W1964310011 hasConcept C181199279 @default.
• W1964310011 hasConcept C193976658 @default.
• W1964310011 hasConcept C203014093 @default.
• W1964310011 hasConcept C2522874641 @default.
• W1964310011 hasConcept C2778170410 @default.
• W1964310011 hasConcept C2780758401 @default.
• W1964310011 hasConcept C40479148 @default.
• W1964310011 hasConcept C54355233 @default.
• W1964310011 hasConcept C55493867 @default.
• W1964310011 hasConcept C58475186 @default.
• W1964310011 hasConcept C81885089 @default.
• W1964310011 hasConcept C86803240 @default.
• W1964310011 hasConcept C92488253 @default.
• W1964310011 hasConcept C95444343 @default.
• W1964310011 hasConcept C98539663 @default.
• W1964310011 hasConceptScore W1964310011C103038307 @default.
• W1964310011 hasConceptScore W1964310011C106257327 @default.
• W1964310011 hasConceptScore W1964310011C108625454 @default.
• W1964310011 hasConceptScore W1964310011C139770010 @default.
• W1964310011 hasConceptScore W1964310011C140704245 @default.
• W1964310011 hasConceptScore W1964310011C147483822 @default.

• next