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- W196431512 abstract "Publisher Summary Antibiotic-associated diarrhea (AAD) is probably the most common manifestation of normal microflora alteration caused by antimicrobial treatment. AAD may be divided into two types: uncomplicated or nonspecific AAD, and Clostridium difficile-associated diarrheas (CDAD). However, studies of AAD and particularly CDAD have shown that damaging of intestinal lactobacilli may play an important role in the pathogenesis of these diseases, and some lactobacilli can be successfully used for protection against CDAD and other AAD. This chapter focuses on the studies concerning the impact of different external factors, particularly antibiotics, on various groups of indigenous microflora and evaluates experimental animal models of CDAD. This approach could predict, which groups of microbes are able to restore the normal symbiosis and help develop further applications of microbial interference therapy and prophylaxis against Clostridium difficile infections. The chapter also discusses some human clinical trials with non-pathogenic commensal lactobacilli that have been considered as probiotics with beneficial health effects, including prevention or amelioration of AAD." @default.
- W196431512 created "2016-06-24" @default.
- W196431512 creator A5004734796 @default.
- W196431512 creator A5009960109 @default.
- W196431512 date "2004-01-01" @default.
- W196431512 modified "2023-10-16" @default.
- W196431512 title "Interactions between Lactobacilli and Antibiotic-Associated Diarrhea" @default.
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