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- W1964317618 abstract "35S-Caerulein (35S-F16934) was administered intramuscularly into rats (280 μg/kg), rabbits (380 μg/kg) and mice (3.3 mg/kg). Blood level of radioactivity in rats and rabbits reached the maximum at 5 and 15 min after administration, respectively, and then decreased rapidly. In both rats and rabbits, the radioactivities were excreted mainly into the urine. The physiological activity of F16934 was detected in the blood of rats and rabbits collected within 15 and 30 min after injection respectively, and in the bile of rats collected within the first 2 hr. In rats, the radioactivities were densely distributed in kidney, liver, pancreas, and intestine. Four metabolites of 35S-FI6934 were isolated by paper chromatography from rat urine (i.m., 500 μg/kg). The main metabolites, F-I and F-II, were negative to nynhydrin and to the Ehrlich reagent and carried no physiological activity. 35S-Chym-I, which was prepared by digesting 35S-F16934 with chymotrypsin, was injected to rats (i.m. 16 or 8 mg/kg). The metabolite, C-I, isolated from the urine was considered to have a very similar structure to F-I from the results of paper chromatography and paper electrophoresis. By amino acid analysis. the structure of C-I was estimated to be as follows:" @default.
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- W1964317618 date "1975-01-01" @default.
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- W1964317618 title "STUDIES ON CAERULEIN (FI6934). ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF CAERULEIN" @default.
- W1964317618 cites W2413082388 @default.
- W1964317618 doi "https://doi.org/10.1254/jjp.25.747" @default.
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