FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964318744> ?p ?o ?g. }

• W1964318744 endingPage "2943" @default.
• W1964318744 startingPage "2932" @default.
• W1964318744 abstract "Copper(II) complexes [Cu(L-arg)(2)](NO(3))(2) (1) and [Cu(L-arg)(B)Cl]Cl (2-5), where B is a heterocyclic base, namely, 2,2'-bipyridine (bpy, 2), 1,10-phenanthroline (phen, 3), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 4), and dipyrido[3,2-a:2',3'-c]phenazine (dppz, 5), are prepared and their DNA binding and photoinduced DNA cleavage activity studied. Ternary complex 3, structurally characterized using X-ray crystallography, shows a square-pyramidal (4 + 1) coordination geometry in which the N,O-donor L-arginine and N,N-donor 1,10-phenanthroline form the basal plane with one chloride at the elongated axial site. The complex has a pendant cationic guanidinium moiety. The one-electron paramagnetic complexes display a metal-centered d-d band in the range of 590-690 nm in aqueous DMF. They show quasireversible cyclic voltammetric response due to the Cu(II)/Cu(I) couple in the range of -0.1 to -0.3 V versus a saturated calomel electrode in a DMF-Tris HCl buffer (pH 7.2). The DNA binding propensity of the complexes is studied using various techniques. Copper(II) bis-arginate 1 mimics the minor groove binder netropsin by showing preferential binding to the AT-rich sequence of double-strand (ds) DNA. DNA binding study using calf thymus DNA gives an order: 5 (L-arg-dppz) > or = 1 (bis-L-arg) > 4 (L-arg-dpq) > 3 (L-arg-phen) >> 2 (L-arg-bpy). Molecular docking calculations reveal that the complexes bind through extensive hydrogen bonding and electrostatic interactions with ds-DNA. The complexes cleave supercoiled pUC19 DNA in the presence of 3-mercaptopropionic acid as a reducing agent forming hydroxyl ((*)OH) radicals. The complexes show oxidative photoinduced DNA cleavage activity in UV-A light of 365 nm and red light of 647.1 nm (Ar-Kr mixed-gas-ion laser) in a metal-assisted photoexcitation process forming singlet oxygen ((1)O(2)) species in a type-II pathway. All of the complexes, barring complex 2, show efficient DNA photocleavage activity. Complexes 4 and 5 exhibit significant double-strand breaks of DNA in red light of 647.1 nm due to the presence of two photosensitizers, namely, L-arginine and dpq or dppz in the molecules." @default.
• W1964318744 created "2016-06-24" @default.
• W1964318744 creator A5021880943 @default.
• W1964318744 creator A5024930481 @default.
• W1964318744 creator A5033798694 @default.
• W1964318744 creator A5042461477 @default.
• W1964318744 creator A5082282211 @default.
• W1964318744 date "2009-03-02" @default.
• W1964318744 modified "2023-09-23" @default.
• W1964318744 title "Copper(II) Complexes of <scp>l</scp>-Arginine as Netropsin Mimics Showing DNA Cleavage Activity in Red Light" @default.
• W1964318744 cites W1590106897 @default.
• W1964318744 cites W1601384284 @default.
• W1964318744 cites W1788240279 @default.
• W1964318744 cites W1913218312 @default.
• W1964318744 cites W1955566737 @default.
• W1964318744 cites W1971114425 @default.
• W1964318744 cites W1972097509 @default.
• W1964318744 cites W1974427934 @default.
• W1964318744 cites W1975213869 @default.
• W1964318744 cites W1979651460 @default.
• W1964318744 cites W1982038922 @default.
• W1964318744 cites W1985446146 @default.
• W1964318744 cites W1987679692 @default.
• W1964318744 cites W1989651677 @default.
• W1964318744 cites W1994426246 @default.
• W1964318744 cites W1997955220 @default.
• W1964318744 cites W1999153581 @default.
• W1964318744 cites W2000554196 @default.
• W1964318744 cites W2000774559 @default.
• W1964318744 cites W2003465708 @default.
• W1964318744 cites W2008075048 @default.
• W1964318744 cites W2012351316 @default.
• W1964318744 cites W2014103085 @default.
• W1964318744 cites W2019809374 @default.
• W1964318744 cites W2019913425 @default.
• W1964318744 cites W2020107720 @default.
• W1964318744 cites W2021268046 @default.
• W1964318744 cites W2023078852 @default.
• W1964318744 cites W2024036911 @default.
• W1964318744 cites W2025234908 @default.
• W1964318744 cites W2027784487 @default.
• W1964318744 cites W2027853919 @default.
• W1964318744 cites W2031346486 @default.
• W1964318744 cites W2032127613 @default.
• W1964318744 cites W2038118870 @default.
• W1964318744 cites W2038124483 @default.
• W1964318744 cites W2042062103 @default.
• W1964318744 cites W2043610941 @default.
• W1964318744 cites W2047406811 @default.
• W1964318744 cites W2047985404 @default.
• W1964318744 cites W2050818396 @default.
• W1964318744 cites W2054607739 @default.
• W1964318744 cites W2055487676 @default.
• W1964318744 cites W2057125903 @default.
• W1964318744 cites W2057541073 @default.
• W1964318744 cites W2059022306 @default.
• W1964318744 cites W2065485865 @default.
• W1964318744 cites W2068256510 @default.
• W1964318744 cites W2070804022 @default.
• W1964318744 cites W2071965775 @default.
• W1964318744 cites W2072166383 @default.
• W1964318744 cites W2072603300 @default.
• W1964318744 cites W2075627152 @default.
• W1964318744 cites W2079046809 @default.
• W1964318744 cites W2084863967 @default.
• W1964318744 cites W2085913223 @default.
• W1964318744 cites W2087182711 @default.
• W1964318744 cites W2101748147 @default.
• W1964318744 cites W2105249240 @default.
• W1964318744 cites W2115942358 @default.
• W1964318744 cites W2123950781 @default.
• W1964318744 cites W2123951007 @default.
• W1964318744 cites W2124531971 @default.
• W1964318744 cites W2127501457 @default.
• W1964318744 cites W2128294421 @default.
• W1964318744 cites W2139701117 @default.
• W1964318744 cites W2140723383 @default.
• W1964318744 cites W2146563007 @default.
• W1964318744 cites W2150656595 @default.
• W1964318744 cites W2156975699 @default.
• W1964318744 cites W2324358039 @default.
• W1964318744 cites W2477765915 @default.
• W1964318744 cites W2798790684 @default.
• W1964318744 cites W2949467840 @default.
• W1964318744 cites W2950664588 @default.
• W1964318744 cites W2952333263 @default.
• W1964318744 cites W2952566998 @default.
• W1964318744 cites W411954668 @default.
• W1964318744 cites W4245397386 @default.
• W1964318744 cites W4251268600 @default.
• W1964318744 doi "https://doi.org/10.1021/ic8017425" @default.
• W1964318744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19254037" @default.
• W1964318744 hasPublicationYear "2009" @default.
• W1964318744 type Work @default.
• W1964318744 sameAs 1964318744 @default.
• W1964318744 citedByCount "136" @default.
• W1964318744 countsByYear W19643187442012 @default.
• W1964318744 countsByYear W19643187442013 @default.

• next