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- W1964322969 abstract "The efficacy of serotonergic pharmacotherapy indicates that serotonin (5-HT) plays a role in the treatment, if not the etiology, of obsessive–compulsive disorder (OCD). While some clinical evidence implicates 5-HT2C receptors in this disorder, a definitive function has yet to be validated. We hypothesized that 5-HT2C receptor knockout (KO) mice may display compulsive-like behavior. This paper describes characterization of several distinct, highly organized behaviors in mice lacking functional 5-HT2C receptors, which supports a compulsive-like syndrome. Compulsive-like behavior was assessed in male 5-HT2C receptor KO and wildtype (WT) mice. Chewing of non-nutritive clay, chewing patterns on plastic-mesh screens, and the frequency of head dipping were measured. 5-HT2C receptor KO mice chewed more clay, produced a distinct pattern of “neat” chewing of plastic screens and exhibited reduced habituation of head dipping activity compared to WT mice. We conclude that the 5-HT2C receptor null mutant mouse provides a promising model of compulsive behavior and a means to further explore the role of 5-HT in OCD." @default.
- W1964322969 created "2016-06-24" @default.
- W1964322969 creator A5052019397 @default.
- W1964322969 creator A5071183105 @default.
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- W1964322969 date "2003-04-01" @default.
- W1964322969 modified "2023-10-11" @default.
- W1964322969 title "Compulsive behavior in the 5-HT2C receptor knockout mouse" @default.
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- W1964322969 doi "https://doi.org/10.1016/s0031-9384(03)00047-7" @default.
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