FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964332980> ?p ?o ?g. }

• W1964332980 endingPage "70" @default.
• W1964332980 startingPage "65" @default.
• W1964332980 abstract "11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the conversion of the glucocorticoid corticosterone (cortisol in humans) to inert 11-dehydrocorticosterone (cortisone). 11 beta-HSD activity is present in the hippocampus, where it is induced by glucocorticoids and stress in vivo, prompting suggestions that the enzyme may attenuate the deleterious effects of chronic glucocorticoid excess on neuronal function and survival. Two isoforms exist: 11 beta-HSD1, a bidirectional NADPH-dependent enzyme, and 11 beta-HSD2, an NAD(+)- dependent exclusive 11 beta-dehydrogenase (corticosterone-inactivating enzyme). In this study, 11 beta-HSD1 activity and mRNA synthesis were demonstrated in primary fetal hippocampal cell cultures. Unexpectedly, the reaction direction in intact hippocampal cells was 11 beta- reduction (reactivation of inert 11-dehydrocorticosterone), although homogenization revealed that the enzyme was capable of 11 beta- dehydrogenation when removed from its normal cellular context. Dexamethasone (10(-7) M) increased 11 beta-HSD activity in homogenates of hippocampal cultures (102% increase). In intact hippocampal cells, dexamethasone induced 11 beta reductase, not dehydrogenase. To determine the functional relevance of hippocampal 11 beta-reductase, glucocorticoid potentiation of kainic acid neurotoxicity was examined. Pretreatment of hippocampal cells with corticosterone reduced survival on kainate exposure. Hippocampal cell 11 beta-HSD activity was potently inhibited by carbenoxolone. Carbenoxolone had no effect on cell survival after kainate alone and did not alter the effect of corticosterone. 11-Dehydrocorticosterone also potentiated kainate neurotoxicity; this effect was lost, however, if 11 beta-HSD was inhibited with carbenoxolone. Thus, hippocampal 11 beta-HSD seems to be a functional 11 beta-reductase in intact cells. Measures to attenuate hippocampal 11 beta-reductase may reduce neuronal vulnerability to glucocorticoid toxicity." @default.
• W1964332980 created "2016-06-24" @default.
• W1964332980 creator A5005011046 @default.
• W1964332980 creator A5030916227 @default.
• W1964332980 creator A5064304317 @default.
• W1964332980 date "1996-01-01" @default.
• W1964332980 modified "2023-10-18" @default.
• W1964332980 title "11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity" @default.
• W1964332980 cites W1264829970 @default.
• W1964332980 cites W136076975 @default.
• W1964332980 cites W1519525780 @default.
• W1964332980 cites W1519712908 @default.
• W1964332980 cites W1642124290 @default.
• W1964332980 cites W177049143 @default.
• W1964332980 cites W1774751156 @default.
• W1964332980 cites W1784804311 @default.
• W1964332980 cites W1871395002 @default.
• W1964332980 cites W1958299123 @default.
• W1964332980 cites W1966962224 @default.
• W1964332980 cites W1969255727 @default.
• W1964332980 cites W1977143695 @default.
• W1964332980 cites W1987354827 @default.
• W1964332980 cites W1994533492 @default.
• W1964332980 cites W1999445328 @default.
• W1964332980 cites W2008050722 @default.
• W1964332980 cites W2009822274 @default.
• W1964332980 cites W2011669749 @default.
• W1964332980 cites W2014212152 @default.
• W1964332980 cites W2019976732 @default.
• W1964332980 cites W2026488506 @default.
• W1964332980 cites W2026812475 @default.
• W1964332980 cites W2027670108 @default.
• W1964332980 cites W2028131204 @default.
• W1964332980 cites W2031667205 @default.
• W1964332980 cites W2047100316 @default.
• W1964332980 cites W2066338366 @default.
• W1964332980 cites W2072546876 @default.
• W1964332980 cites W2072847456 @default.
• W1964332980 cites W2074802748 @default.
• W1964332980 cites W2085299994 @default.
• W1964332980 cites W2094796104 @default.
• W1964332980 cites W2124888129 @default.
• W1964332980 cites W2134812217 @default.
• W1964332980 cites W2137036502 @default.
• W1964332980 cites W2142464121 @default.
• W1964332980 cites W2148114970 @default.
• W1964332980 cites W2152902566 @default.
• W1964332980 cites W2464773813 @default.
• W1964332980 cites W2480212967 @default.
• W1964332980 doi "https://doi.org/10.1523/jneurosci.16-01-00065.1996" @default.
• W1964332980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6578723" @default.
• W1964332980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8613810" @default.
• W1964332980 hasPublicationYear "1996" @default.
• W1964332980 type Work @default.
• W1964332980 sameAs 1964332980 @default.
• W1964332980 citedByCount "160" @default.
• W1964332980 countsByYear W19643329802012 @default.
• W1964332980 countsByYear W19643329802013 @default.
• W1964332980 countsByYear W19643329802014 @default.
• W1964332980 countsByYear W19643329802015 @default.
• W1964332980 countsByYear W19643329802016 @default.
• W1964332980 countsByYear W19643329802018 @default.
• W1964332980 countsByYear W19643329802019 @default.
• W1964332980 countsByYear W19643329802021 @default.
• W1964332980 countsByYear W19643329802023 @default.
• W1964332980 crossrefType "journal-article" @default.
• W1964332980 hasAuthorship W1964332980A5005011046 @default.
• W1964332980 hasAuthorship W1964332980A5030916227 @default.
• W1964332980 hasAuthorship W1964332980A5064304317 @default.
• W1964332980 hasBestOaLocation W19643329801 @default.
• W1964332980 hasConcept C126322002 @default.
• W1964332980 hasConcept C134018914 @default.
• W1964332980 hasConcept C148762608 @default.
• W1964332980 hasConcept C158157758 @default.
• W1964332980 hasConcept C160268369 @default.
• W1964332980 hasConcept C170493617 @default.
• W1964332980 hasConcept C185592680 @default.
• W1964332980 hasConcept C189184402 @default.
• W1964332980 hasConcept C2779491297 @default.
• W1964332980 hasConcept C2780352252 @default.
• W1964332980 hasConcept C2780841215 @default.
• W1964332980 hasConcept C2780961449 @default.
• W1964332980 hasConcept C29730261 @default.
• W1964332980 hasConcept C55493867 @default.
• W1964332980 hasConcept C61174792 @default.
• W1964332980 hasConcept C71315377 @default.
• W1964332980 hasConcept C71924100 @default.
• W1964332980 hasConcept C79879829 @default.
• W1964332980 hasConcept C86803240 @default.
• W1964332980 hasConceptScore W1964332980C126322002 @default.
• W1964332980 hasConceptScore W1964332980C134018914 @default.
• W1964332980 hasConceptScore W1964332980C148762608 @default.
• W1964332980 hasConceptScore W1964332980C158157758 @default.
• W1964332980 hasConceptScore W1964332980C160268369 @default.
• W1964332980 hasConceptScore W1964332980C170493617 @default.
• W1964332980 hasConceptScore W1964332980C185592680 @default.
• W1964332980 hasConceptScore W1964332980C189184402 @default.
• W1964332980 hasConceptScore W1964332980C2779491297 @default.

• next