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• W1964333423 abstract "BHK cells either untreated or infected with Semliki Forest virus have been fractionated on sucrose density gradients. Virus infection caused an increase in density of a membrane fraction enriched in sphingomyelin (SM), cholesterol, SM synthase and sialyltransferase activity. This increase in density was related to incorporation of viral proteins into this fraction, which is likely to contain trans-Golgi network (TGN) membranes. In contrast, glucosylceramide synthase and galactosyltransferase activities (markers for cis/medial and trans-Golgi respectively) underwent no density shift and alkaline phosphodiesterase, a plasma membrane marker, was only slightly density-shifted in infected cells. When cells were incubated with NBD-ceramide to enable them to synthesise NBD-SM and then washed with albumin to remove surface label, fluorescence in untreated cells was concentrated in a single juxtanuclear spot but in infected cells this region of bright fluorescence was larger and extended around the nucleus. After fractionation of these cells, NBD-SM (but only a small proportion of the NBD-ceramide) was found to be shifted into the higher density fraction in infected cells. This work provides further evidence that SM synthase is not mainly localised in the early Golgi cisternae as previously thought, but is associated more with a cholesterol-rich compartment which could be the TGN." @default.
• W1964333423 created "2016-06-24" @default.
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• W1964333423 date "1999-07-01" @default.
• W1964333423 modified "2023-09-25" @default.
• W1964333423 title "Enzyme distributions in subcellular fractions of BHK cells infected with Semliki Forest virus: evidence for a major fraction of sphingomyelin synthase in the trans-Golgi network" @default.
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• W1964333423 doi "https://doi.org/10.1016/s0167-4889(99)00057-9" @default.
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