FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964333485> ?p ?o ?g. }

• W1964333485 endingPage "e43123" @default.
• W1964333485 startingPage "e43123" @default.
• W1964333485 abstract "In vivo high-resolution micro-computed tomography allows for longitudinal image-based measurements in animal models of lung disease. The combination of repetitive high resolution imaging with fully automated quantitative image analysis in mouse models of lung fibrosis lung benefits preclinical research. This study aimed to develop and validate such an automated micro-computed tomography analysis algorithm for quantification of aerated lung volume in mice; an indicator of pulmonary fibrosis and emphysema severity.Mice received an intratracheal instillation of bleomycin (n = 8), elastase (0.25 U elastase n = 9, 0.5 U elastase n = 8) or saline control (n = 6 for fibrosis, n = 5 for emphysema). A subset of mice was scanned without intervention, to evaluate potential radiation-induced toxicity (n = 4). Some bleomycin-instilled mice were treated with imatinib for proof of concept (n = 8). Mice were scanned weekly, until four weeks after induction, when they underwent pulmonary function testing, lung histology and collagen quantification. Aerated lung volumes were calculated with our automated algorithm.Our automated image-based aerated lung volume quantification method is reproducible with low intra-subject variability. Bleomycin-treated mice had significantly lower scan-derived aerated lung volumes, compared to controls. Aerated lung volume correlated with the histopathological fibrosis score and total lung collagen content. Inversely, a dose-dependent increase in lung volume was observed in elastase-treated mice. Serial scanning of individual mice is feasible and visualized dynamic disease progression. No radiation-induced toxicity was observed. Three-dimensional images provided critical topographical information.We report on a high resolution in vivo micro-computed tomography image analysis algorithm that runs fully automated and allows quantification of aerated lung volume in mice. This method is reproducible with low inherent measurement variability. We show that it is a reliable quantitative tool to investigate experimental lung fibrosis and emphysema in mice. Its non-invasive nature has the unique benefit to allow dynamic 4D evaluation of disease processes and therapeutic interventions." @default.
• W1964333485 created "2016-06-24" @default.
• W1964333485 creator A5004293803 @default.
• W1964333485 creator A5018912842 @default.
• W1964333485 creator A5039892511 @default.
• W1964333485 creator A5048235718 @default.
• W1964333485 creator A5053106594 @default.
• W1964333485 creator A5054090330 @default.
• W1964333485 creator A5059823367 @default.
• W1964333485 creator A5065124015 @default.
• W1964333485 date "2012-08-13" @default.
• W1964333485 modified "2023-10-17" @default.
• W1964333485 title "Quantification of Lung Fibrosis and Emphysema in Mice Using Automated Micro-Computed Tomography" @default.
• W1964333485 cites W1974610140 @default.
• W1964333485 cites W2001690919 @default.
• W1964333485 cites W2006406032 @default.
• W1964333485 cites W2029747560 @default.
• W1964333485 cites W2034462747 @default.
• W1964333485 cites W2065977597 @default.
• W1964333485 cites W2066749771 @default.
• W1964333485 cites W2067565872 @default.
• W1964333485 cites W2073502454 @default.
• W1964333485 cites W2075400164 @default.
• W1964333485 cites W2075982355 @default.
• W1964333485 cites W2092432728 @default.
• W1964333485 cites W2093140780 @default.
• W1964333485 cites W2117488044 @default.
• W1964333485 cites W2118948459 @default.
• W1964333485 cites W2140839448 @default.
• W1964333485 cites W2141088484 @default.
• W1964333485 cites W2142513442 @default.
• W1964333485 cites W2158556821 @default.
• W1964333485 cites W2159759971 @default.
• W1964333485 cites W2161738612 @default.
• W1964333485 cites W2165413349 @default.
• W1964333485 cites W2167211373 @default.
• W1964333485 cites W2172021778 @default.
• W1964333485 cites W2995689359 @default.
• W1964333485 doi "https://doi.org/10.1371/journal.pone.0043123" @default.
• W1964333485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418271" @default.
• W1964333485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22912805" @default.
• W1964333485 hasPublicationYear "2012" @default.
• W1964333485 type Work @default.
• W1964333485 sameAs 1964333485 @default.
• W1964333485 citedByCount "95" @default.
• W1964333485 countsByYear W19643334852013 @default.
• W1964333485 countsByYear W19643334852014 @default.
• W1964333485 countsByYear W19643334852015 @default.
• W1964333485 countsByYear W19643334852016 @default.
• W1964333485 countsByYear W19643334852017 @default.
• W1964333485 countsByYear W19643334852018 @default.
• W1964333485 countsByYear W19643334852019 @default.
• W1964333485 countsByYear W19643334852020 @default.
• W1964333485 countsByYear W19643334852021 @default.
• W1964333485 countsByYear W19643334852022 @default.
• W1964333485 countsByYear W19643334852023 @default.
• W1964333485 crossrefType "journal-article" @default.
• W1964333485 hasAuthorship W1964333485A5004293803 @default.
• W1964333485 hasAuthorship W1964333485A5018912842 @default.
• W1964333485 hasAuthorship W1964333485A5039892511 @default.
• W1964333485 hasAuthorship W1964333485A5048235718 @default.
• W1964333485 hasAuthorship W1964333485A5053106594 @default.
• W1964333485 hasAuthorship W1964333485A5054090330 @default.
• W1964333485 hasAuthorship W1964333485A5059823367 @default.
• W1964333485 hasAuthorship W1964333485A5065124015 @default.
• W1964333485 hasBestOaLocation W19643334851 @default.
• W1964333485 hasConcept C126322002 @default.
• W1964333485 hasConcept C126838900 @default.
• W1964333485 hasConcept C142724271 @default.
• W1964333485 hasConcept C150903083 @default.
• W1964333485 hasConcept C181199279 @default.
• W1964333485 hasConcept C185592680 @default.
• W1964333485 hasConcept C207001950 @default.
• W1964333485 hasConcept C27101514 @default.
• W1964333485 hasConcept C2776232574 @default.
• W1964333485 hasConcept C2776326425 @default.
• W1964333485 hasConcept C2776694085 @default.
• W1964333485 hasConcept C2777524225 @default.
• W1964333485 hasConcept C2777714996 @default.
• W1964333485 hasConcept C2777825092 @default.
• W1964333485 hasConcept C2780559512 @default.
• W1964333485 hasConcept C2781044401 @default.
• W1964333485 hasConcept C2781244666 @default.
• W1964333485 hasConcept C2989005 @default.
• W1964333485 hasConcept C55493867 @default.
• W1964333485 hasConcept C71924100 @default.
• W1964333485 hasConcept C75603125 @default.
• W1964333485 hasConcept C86803240 @default.
• W1964333485 hasConceptScore W1964333485C126322002 @default.
• W1964333485 hasConceptScore W1964333485C126838900 @default.
• W1964333485 hasConceptScore W1964333485C142724271 @default.
• W1964333485 hasConceptScore W1964333485C150903083 @default.
• W1964333485 hasConceptScore W1964333485C181199279 @default.
• W1964333485 hasConceptScore W1964333485C185592680 @default.
• W1964333485 hasConceptScore W1964333485C207001950 @default.
• W1964333485 hasConceptScore W1964333485C27101514 @default.
• W1964333485 hasConceptScore W1964333485C2776232574 @default.
• W1964333485 hasConceptScore W1964333485C2776326425 @default.

• next