Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964334815> ?p ?o ?g. }
- W1964334815 endingPage "127" @default.
- W1964334815 startingPage "119" @default.
- W1964334815 abstract "Adlay (Job's tears, Coix lachryma-jobi L. var. ma-yuen Stapf) has long been used in China to treat rheumatism. We investigated the anti-allergic effects of adlay bran on rat basophilic leukemia (RBL)-2H3 cells. To evaluate the anti-allergic effects of adlay bran, the release of histamines and cytokines were measured using ELISA. To explore the mechanism of these effects, the protein expression levels were determined using western blotting. A 40.8 μg/mL concentration of the ethyl acetate fraction of the ethanolic extracts of adlay bran (ABE-EtOAc) effectively inhibited mast cell degranulation. The 40–100% EtOAc/Hex subfractions of ABE-EtOAc inhibited histamine release with an IC50 of 71–87 μg/mL. Moreover, the ABE-EtOAc subfractions suppressed the secretion of interleukin (IL)-4, IL-6 and tumor necrosis factor-α in the RBL-2H3 cells, indicating that adlay bran can inhibit cytokine secretion in the late phase of the allergic reaction. In addition, adlay bran reduced the intracellular production of reactive oxygen species, inhibited the phosphorylation of Akt and decreased the expression of protein kinase C. Furthermore, six phenolic acids and one flavone were isolated. Of these compounds, luteolin showed the most potent inhibitory activity (IC50 = 1.5 μg/mL). Adlay bran extract reduced the release of histamines and cytokines and suppressed the production of Akt. These combined effects influenced the signal transduction in RBL-2H3 cells, thereby revealing the mechanisms of the anti-allergic effects of adlay." @default.
- W1964334815 created "2016-06-24" @default.
- W1964334815 creator A5014832869 @default.
- W1964334815 creator A5087785864 @default.
- W1964334815 creator A5089300007 @default.
- W1964334815 date "2012-05-01" @default.
- W1964334815 modified "2023-09-30" @default.
- W1964334815 title "Inhibitory effects of adlay bran (Coix lachryma-jobi L. var. ma-yuen Stapf) on chemical mediator release and cytokine production in rat basophilic leukemia cells" @default.
- W1964334815 cites W1553372211 @default.
- W1964334815 cites W1602890676 @default.
- W1964334815 cites W1968391579 @default.
- W1964334815 cites W1970110695 @default.
- W1964334815 cites W1973193612 @default.
- W1964334815 cites W1979674265 @default.
- W1964334815 cites W1986543196 @default.
- W1964334815 cites W198804881 @default.
- W1964334815 cites W1998073646 @default.
- W1964334815 cites W2004055100 @default.
- W1964334815 cites W2009389811 @default.
- W1964334815 cites W2015082452 @default.
- W1964334815 cites W2017668832 @default.
- W1964334815 cites W2027407517 @default.
- W1964334815 cites W2029884741 @default.
- W1964334815 cites W2031600293 @default.
- W1964334815 cites W2034793872 @default.
- W1964334815 cites W2035030129 @default.
- W1964334815 cites W2036193906 @default.
- W1964334815 cites W2043435450 @default.
- W1964334815 cites W2046575948 @default.
- W1964334815 cites W2048141990 @default.
- W1964334815 cites W2049374822 @default.
- W1964334815 cites W2050177770 @default.
- W1964334815 cites W2056741044 @default.
- W1964334815 cites W2057134405 @default.
- W1964334815 cites W2064180188 @default.
- W1964334815 cites W2064636154 @default.
- W1964334815 cites W2070821878 @default.
- W1964334815 cites W2075265720 @default.
- W1964334815 cites W2076248870 @default.
- W1964334815 cites W2092746799 @default.
- W1964334815 cites W2093266126 @default.
- W1964334815 cites W2136397681 @default.
- W1964334815 cites W2138843929 @default.
- W1964334815 cites W4313317760 @default.
- W1964334815 doi "https://doi.org/10.1016/j.jep.2012.02.009" @default.
- W1964334815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22353428" @default.
- W1964334815 hasPublicationYear "2012" @default.
- W1964334815 type Work @default.
- W1964334815 sameAs 1964334815 @default.
- W1964334815 citedByCount "46" @default.
- W1964334815 countsByYear W19643348152012 @default.
- W1964334815 countsByYear W19643348152013 @default.
- W1964334815 countsByYear W19643348152014 @default.
- W1964334815 countsByYear W19643348152015 @default.
- W1964334815 countsByYear W19643348152016 @default.
- W1964334815 countsByYear W19643348152017 @default.
- W1964334815 countsByYear W19643348152018 @default.
- W1964334815 countsByYear W19643348152019 @default.
- W1964334815 countsByYear W19643348152020 @default.
- W1964334815 countsByYear W19643348152021 @default.
- W1964334815 countsByYear W19643348152022 @default.
- W1964334815 countsByYear W19643348152023 @default.
- W1964334815 crossrefType "journal-article" @default.
- W1964334815 hasAuthorship W1964334815A5014832869 @default.
- W1964334815 hasAuthorship W1964334815A5087785864 @default.
- W1964334815 hasAuthorship W1964334815A5089300007 @default.
- W1964334815 hasConcept C1122143 @default.
- W1964334815 hasConcept C142724271 @default.
- W1964334815 hasConcept C170493617 @default.
- W1964334815 hasConcept C178790620 @default.
- W1964334815 hasConcept C185592680 @default.
- W1964334815 hasConcept C188947578 @default.
- W1964334815 hasConcept C202751555 @default.
- W1964334815 hasConcept C203014093 @default.
- W1964334815 hasConcept C204787440 @default.
- W1964334815 hasConcept C206139338 @default.
- W1964334815 hasConcept C2776873940 @default.
- W1964334815 hasConcept C2777752497 @default.
- W1964334815 hasConcept C2778690821 @default.
- W1964334815 hasConcept C2781074434 @default.
- W1964334815 hasConcept C49802076 @default.
- W1964334815 hasConcept C55493867 @default.
- W1964334815 hasConcept C556039675 @default.
- W1964334815 hasConcept C71924100 @default.
- W1964334815 hasConcept C86803240 @default.
- W1964334815 hasConcept C98274493 @default.
- W1964334815 hasConceptScore W1964334815C1122143 @default.
- W1964334815 hasConceptScore W1964334815C142724271 @default.
- W1964334815 hasConceptScore W1964334815C170493617 @default.
- W1964334815 hasConceptScore W1964334815C178790620 @default.
- W1964334815 hasConceptScore W1964334815C185592680 @default.
- W1964334815 hasConceptScore W1964334815C188947578 @default.
- W1964334815 hasConceptScore W1964334815C202751555 @default.
- W1964334815 hasConceptScore W1964334815C203014093 @default.
- W1964334815 hasConceptScore W1964334815C204787440 @default.
- W1964334815 hasConceptScore W1964334815C206139338 @default.
- W1964334815 hasConceptScore W1964334815C2776873940 @default.
- W1964334815 hasConceptScore W1964334815C2777752497 @default.