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- W1964343015 abstract "To investigate the antidiabetic effect of aqueous extract of Merremia tridentata (M. tridentata) root (MTRAE) in normal, glucose-loaded hyperglycemic and streptozotocin (STZ)-induced diabetic rats.Oral administration of MTRAE at the doses of 50, 100 and 150 mg/kg was studied in normal, glucose-loaded and STZ-diabetic rats. The three doses caused significant reduction in blood glucose levels in all the models.The effect was more pronounced in 100 and 150 mg/kg than 50 mg/kg. MTRAE also showed significant increase in serum insulin, body weight and glycogen content in liver and skeletal muscle of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. MTRAE also showed significant antilipidperoxidative effect in the pancreas of STZ-induced diabetic rats. The antidiabetic effect of M. tridentata was compared with glibenclamide, a well known hypoglycemic drug.The results indicate that aqueous extract of M. tridentata root possesses significant antidiabetic activity." @default.
- W1964343015 created "2016-06-24" @default.
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- W1964343015 date "2012-03-01" @default.
- W1964343015 modified "2023-10-16" @default.
- W1964343015 title "Antidiabetic activity of aqueous root extract of Merremia tridentata (L.) Hall. f. in streptozotocin–induced–diabetic rats" @default.
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- W1964343015 doi "https://doi.org/10.1016/s1995-7645(12)60020-0" @default.
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