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• W1964345623 abstract "Upon an increasing cell density human neutrophils develop more cell-to-cell contacts in conjunction with an increase in the pHi. These changes are accompanied by decreased superoxide formation after adherence, and a decrease in the total amount of 5-lipoxygenase products after various stimuli. Among the various arachidonate metabolites, leukotriene formation remained almost constant but the yield in 5-HETE decreased. This drop in could account for the decrease in total 5-lipoxygenase products observed when the cell density increased. We conclude that cellular signalling can be affected by an increase of cell-cell interactions. Whether the increase in cellular pH is a cause or consequence of such contact inhibition has yet be answered." @default.
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• W1964345623 date "1998-01-01" @default.
• W1964345623 modified "2023-09-23" @default.
• W1964345623 title "Dependence of Neutrophil Activation on Cell Density and Adhesion" @default.
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• W1964345623 doi "https://doi.org/10.3109/15419069809005596" @default.
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