FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964348528> ?p ?o ?g. }

• W1964348528 abstract "Abstract Background A precise balance exists between the actions of endogenous glucocorticoids (GC) and retinoids to promote normal lung development, in particular during alveolarization. The mechanisms controlling this balance are largely unknown, but recent evidence suggests that midkine (MK), a retinoic acid-regulated, pro-angiogenic growth factor, may function as a critical regulator. The purpose of this study was to examine regulation of MK by GC and RA during postnatal alveolar formation in rats. Methods Newborn rats were treated with dexamethasone (DEX) and/or all-trans-retinoic acid (RA) during the first two weeks of life. Lung morphology was assessed by light microscopy and radial alveolar counts. MK mRNA and protein expression in response to different treatment were determined by Northern and Western blots. In addition, MK protein expression in cultured human alveolar type 2-like cells treated with DEX and RA was also determined. Results Lung histology confirmed that DEX treatment inhibited and RA treatment stimulated alveolar formation, whereas concurrent administration of RA with DEX prevented the DEX effects. During normal development, MK expression was maximal during the period of alveolarization from postnatal day 5 (PN5) to PN15. DEX treatment of rat pups decreased, and RA treatment increased lung MK expression, whereas concurrent DEX+RA treatment prevented the DEX-induced decrease in MK expression. Using human alveolar type 2 (AT2)-like cells differentiated in culture, we confirmed that DEX and cAMP decreased, and RA increased MK expression. Conclusion We conclude that MK is expressed by AT2 cells, and is differentially regulated by corticosteroid and retinoid treatment in a manner consistent with hormonal effects on alveolarization during postnatal lung development." @default.
• W1964348528 created "2016-06-24" @default.
• W1964348528 creator A5009309767 @default.
• W1964348528 creator A5012914873 @default.
• W1964348528 creator A5017097151 @default.
• W1964348528 creator A5017620521 @default.
• W1964348528 creator A5040261310 @default.
• W1964348528 creator A5046376308 @default.
• W1964348528 creator A5050338024 @default.
• W1964348528 creator A5058829365 @default.
• W1964348528 creator A5068458494 @default.
• W1964348528 creator A5073426620 @default.
• W1964348528 date "2009-08-21" @default.
• W1964348528 modified "2023-10-14" @default.
• W1964348528 title "The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells" @default.
• W1964348528 cites W1574299769 @default.
• W1964348528 cites W1589927530 @default.
• W1964348528 cites W1747167238 @default.
• W1964348528 cites W1964294676 @default.
• W1964348528 cites W1970760791 @default.
• W1964348528 cites W1973417006 @default.
• W1964348528 cites W1974465632 @default.
• W1964348528 cites W1974927122 @default.
• W1964348528 cites W1980584486 @default.
• W1964348528 cites W1986180694 @default.
• W1964348528 cites W1988557297 @default.
• W1964348528 cites W1988909864 @default.
• W1964348528 cites W2007608595 @default.
• W1964348528 cites W2011050399 @default.
• W1964348528 cites W2018839286 @default.
• W1964348528 cites W2026246057 @default.
• W1964348528 cites W2032040395 @default.
• W1964348528 cites W2052191146 @default.
• W1964348528 cites W2066029878 @default.
• W1964348528 cites W2068818088 @default.
• W1964348528 cites W2070038950 @default.
• W1964348528 cites W2077614430 @default.
• W1964348528 cites W2084066835 @default.
• W1964348528 cites W2087946061 @default.
• W1964348528 cites W2089543148 @default.
• W1964348528 cites W2098391873 @default.
• W1964348528 cites W2098840758 @default.
• W1964348528 cites W2106071352 @default.
• W1964348528 cites W2106846696 @default.
• W1964348528 cites W2115163495 @default.
• W1964348528 cites W2121308413 @default.
• W1964348528 cites W2125926218 @default.
• W1964348528 cites W2127168252 @default.
• W1964348528 cites W2132902482 @default.
• W1964348528 cites W2149517662 @default.
• W1964348528 cites W2159874728 @default.
• W1964348528 cites W2169762564 @default.
• W1964348528 cites W2200717541 @default.
• W1964348528 cites W2317327165 @default.
• W1964348528 cites W2327940859 @default.
• W1964348528 cites W2329468234 @default.
• W1964348528 cites W2336737908 @default.
• W1964348528 cites W2338071630 @default.
• W1964348528 cites W2407531511 @default.
• W1964348528 cites W4230234871 @default.
• W1964348528 doi "https://doi.org/10.1186/1465-9921-10-77" @default.
• W1964348528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2739515" @default.
• W1964348528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19698107" @default.
• W1964348528 hasPublicationYear "2009" @default.
• W1964348528 type Work @default.
• W1964348528 sameAs 1964348528 @default.
• W1964348528 citedByCount "15" @default.
• W1964348528 countsByYear W19643485282012 @default.
• W1964348528 countsByYear W19643485282013 @default.
• W1964348528 countsByYear W19643485282015 @default.
• W1964348528 countsByYear W19643485282018 @default.
• W1964348528 countsByYear W19643485282019 @default.
• W1964348528 countsByYear W19643485282020 @default.
• W1964348528 crossrefType "journal-article" @default.
• W1964348528 hasAuthorship W1964348528A5009309767 @default.
• W1964348528 hasAuthorship W1964348528A5012914873 @default.
• W1964348528 hasAuthorship W1964348528A5017097151 @default.
• W1964348528 hasAuthorship W1964348528A5017620521 @default.
• W1964348528 hasAuthorship W1964348528A5040261310 @default.
• W1964348528 hasAuthorship W1964348528A5046376308 @default.
• W1964348528 hasAuthorship W1964348528A5050338024 @default.
• W1964348528 hasAuthorship W1964348528A5058829365 @default.
• W1964348528 hasAuthorship W1964348528A5068458494 @default.
• W1964348528 hasAuthorship W1964348528A5073426620 @default.
• W1964348528 hasBestOaLocation W19643485281 @default.
• W1964348528 hasConcept C126322002 @default.
• W1964348528 hasConcept C134018914 @default.
• W1964348528 hasConcept C158074577 @default.
• W1964348528 hasConcept C170493617 @default.
• W1964348528 hasConcept C2775954498 @default.
• W1964348528 hasConcept C2775960820 @default.
• W1964348528 hasConcept C2777714996 @default.
• W1964348528 hasConcept C2779963572 @default.
• W1964348528 hasConcept C2780401358 @default.
• W1964348528 hasConcept C2780841215 @default.
• W1964348528 hasConcept C2781121885 @default.
• W1964348528 hasConcept C54355233 @default.
• W1964348528 hasConcept C71924100 @default.
• W1964348528 hasConcept C81885089 @default.
• W1964348528 hasConcept C86803240 @default.

• next