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- W1964351036 abstract "Abstract We have treated 59 patients with disseminated or inoperable malignant melanoma with a combination of chemotherapy (D.T.I.C.) and immunotherapy (comprising irradiated allogeneic melanoma cells plus BCG) and have followed their progress for a minimum of ten months. Objective tumour regression was observed in 44% of the patients but most of these patients relapsed despite continued treatment, the longest complete regression lasting 21 months. Patients with disease confined to the skin, lymph nodes or lungs had a higher regression rate ( 19 34 as against 7 25 ) and survived longer than those with visceral, osseous or cerebral metastases. Complete regressions were commoner in women but the overall regression rate was the same in both sexes. By comparison of these results with literature controls and from the inexorable decline in the survival curves we conclude that despite its apparent effect on objective regression rate this form of combination immunotherapy-chemotherapy has little or no worthwhile effect on survival." @default.
- W1964351036 created "2016-06-24" @default.
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- W1964351036 date "1977-10-01" @default.
- W1964351036 modified "2023-09-26" @default.
- W1964351036 title "Tumour regression and survival of patients with disseminated malignant melanoma treated with chemotherapy and specific active immunotherapy" @default.
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- W1964351036 doi "https://doi.org/10.1016/0014-2964(77)90017-2" @default.
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