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- W1964351331 abstract "Understanding COPD exacerbation-associated burden, particularly in severe (SEV) and very severe (VSEV) patients, can help improve medication management. To describe exacerbation frequency, treatment, work productivity, and health-related quality of life (HRQoL) for patients with SEV/VSEV COPD who recently experienced a moderate (MOD)/SEV exacerbation. A nationally representative sample of SEV/VSEV COPD patients who had experienced a MOD/SEV exacerbation within the past 3 months was physician recruited. Medical charts were evaluated for patient demographic/clinical data, including exacerbation frequency in the previous 12 months, work productivity and impairment (WPAI), and HRQoL (St. George’s Respiratory Questionnaire for COPD, SGRQ-C). This study included 314 patients (190 SEV/124 VSEV). VSEV (vs. SEV) patients were more likely to be Caucasian (93.5% versus 82.1%, P=0.004) and had SEV last exacerbation (44.3% vs. 29.5%, P=0.016). These 314 patients experienced 829 exacerbations in the previous 12 months, of which 556 were MOD (17.2% treated with antibiotics only; 70.7% with steroids and antibiotics; 12.1% with steroids only), and 273 were SEV (19.6% treated in the ER; 53.7% hospitalized with an ER visit; 26.7% hospitalized without ER visit). 15.9% of patients (SEV 19.5%/VSEV 10.5%, P=0.033) were employed but reported a high percentage of overall work impairment (42.4%±31.1%) due to absenteeism/presenteeism. Activity impairment was 58.7%±28.0% across all patients. SGRQ-C scores (0-100=best-worst health) were: Total 64.7±20.4, Symptoms 70.6±19.0, Activities 78.0±21.9, and Impacts 54.7±24.8, with total scores being significantly worse for VSEV (vs. SEV COPD; 70.1±21.3 vs. 61.1±19.0; P<0.001) and SEV last exacerbation (vs. MOD; 70.3±19.9 vs. 61.7±20.1; P<0.001). MOD/SEV exacerbations in SEV/VSEV COPD patients impaired patients’ work productivity and were associated with poor HRQoL. Since patients with a recent MOD/SEV exacerbation were highly likely to have experienced mild/MOD/SEV exacerbations in the previous year, interventions to further reduce exacerbations will likely have a strong impact on patient HRQoL." @default.
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- W1964351331 date "2013-05-01" @default.
- W1964351331 modified "2023-09-26" @default.
- W1964351331 title "Impact Of Severe And Very Severe Chronic Obstructive Pulmonary Disease (Copd) On Health-Related Quality Of Life (Hrqol) And Work Productivity: Results Of A Nationally Representative Patient Survey And Chart Review Of Recently Exacerbating Patients" @default.
- W1964351331 doi "https://doi.org/10.1016/j.jval.2013.03.1219" @default.
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