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• W1964366645 abstract "SummaryBackground: Among the chemokines related to CXC and CC receptor groups and released from platelets, leukocytes and endothelial cells, SDF‐1, TARC and MDC have been found to be platelet agonists. Platelets do not contain SDF‐1α. In contrast, RANTES is constitutively present in platelet α‐granules and released upon platelet activation. Objectives: To study a possible role of RANTES as a modulator of SDF‐1α effect on platelets, in relation to CXCR4 and various CC receptors. Methods: CXCR‐4 (CXCL12) receptor expression and platelet activation were evaluated by flow cytometry, platelet deposition was studied by cone and plate(let) analyzer, and platelet aggregation by turbidometric aggregometry. Results: Flow cytometry studies revealed similar expression of CXCR‐4, the specific receptor of SDF‐1α on intact, inactivated, and activated platelets. Preincubation of platelets with RANTES affected neither CXCR‐4 expression, nor SDF‐1α binding to the platelet membrane. In the presence of fibrinogen, SDF‐1α activated gel‐filtered platelets. RANTES did not activate platelets, but substantially (by 70%) inhibited SDF‐1α‐induced fibrinogen binding. Similarly, RANTES abrogated the promoting effect of SDF‐1α on whole blood platelet adhesion to endothelial cell monolayer under venous flow conditions. In platelet‐rich plasma, RANTES moderately inhibited SDF‐1α‐induced platelet aggregation, while it did not affect aggregation induced by thrombin‐receptor activation peptide, adenosine diphosphate, or phorbol 12‐myristate 13‐acetate. A synergistic inhibitory effect of RANTES and prostaglandin E1 used at subthreshold concentrations, on SDF‐1α‐induced aggregation and SDF‐1α‐induced fibrinogen binding to platelets was observed, which may suggest involvement of RANTES in a cAMP‐dependent signal transduction pathway. Conclusions: RANTES non‐competitively inhibits activation of platelets by SDF‐1α, and thus may play a regulatory role in platelet response to inflammation. Background: Among the chemokines related to CXC and CC receptor groups and released from platelets, leukocytes and endothelial cells, SDF‐1, TARC and MDC have been found to be platelet agonists. Platelets do not contain SDF‐1α. In contrast, RANTES is constitutively present in platelet α‐granules and released upon platelet activation. Objectives: To study a possible role of RANTES as a modulator of SDF‐1α effect on platelets, in relation to CXCR4 and various CC receptors. Methods: CXCR‐4 (CXCL12) receptor expression and platelet activation were evaluated by flow cytometry, platelet deposition was studied by cone and plate(let) analyzer, and platelet aggregation by turbidometric aggregometry. Results: Flow cytometry studies revealed similar expression of CXCR‐4, the specific receptor of SDF‐1α on intact, inactivated, and activated platelets. Preincubation of platelets with RANTES affected neither CXCR‐4 expression, nor SDF‐1α binding to the platelet membrane. In the presence of fibrinogen, SDF‐1α activated gel‐filtered platelets. RANTES did not activate platelets, but substantially (by 70%) inhibited SDF‐1α‐induced fibrinogen binding. Similarly, RANTES abrogated the promoting effect of SDF‐1α on whole blood platelet adhesion to endothelial cell monolayer under venous flow conditions. In platelet‐rich plasma, RANTES moderately inhibited SDF‐1α‐induced platelet aggregation, while it did not affect aggregation induced by thrombin‐receptor activation peptide, adenosine diphosphate, or phorbol 12‐myristate 13‐acetate. A synergistic inhibitory effect of RANTES and prostaglandin E1 used at subthreshold concentrations, on SDF‐1α‐induced aggregation and SDF‐1α‐induced fibrinogen binding to platelets was observed, which may suggest involvement of RANTES in a cAMP‐dependent signal transduction pathway. Conclusions: RANTES non‐competitively inhibits activation of platelets by SDF‐1α, and thus may play a regulatory role in platelet response to inflammation." @default.
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• W1964366645 date "2004-01-01" @default.
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• W1964366645 title "Differential response of platelets to chemokines: RANTES non‐competitively inhibits stimulatory effect of SDF‐1α" @default.
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• W1964366645 doi "https://doi.org/10.1111/j.1538-7836.2004.00527.x" @default.
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