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- W1964366928 abstract "Fifty mg/kg of ergot alkaloid dihydroergosine (DHESN) inhibited the mouse-killing behavior of isolated male rats, while 10 mg/kg did not. This effect of DHESN (50 mg/kg) lasted for 24 hr. When an additional injection of DHESN (50 mg/kg) was given to mouse-killer rats 6 days following the first, the mouse-killing behavior was again inhibited. The effect of the second drug injection also persisted for 24 hr and was accompanied by an increased concentration of 5-HT in the raphe nuclei and hypothalamus and by a decreased concentration of GABA in the olfactory bulbs. DHESN also inhibited aggressiveness in isolated mice. Two hr following the administration of 10 mg/kg DHESN the fighting was inhibited in 46% of pairs tested, while 50 mg/kg abolished it completely. The effect of 50 mg/kg lasted 24 hr. These results, showing the antiaggressive effects of DHESN, support our previous suggestion that DHESN might presumably be a new antidepressant, and suggest that besides the serotoninergic, the GABA-ergic system might also be involved in the modification of behavior induced by this drug." @default.
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- W1964366928 date "1989-01-01" @default.
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- W1964366928 title "Inhibitory influence of dihydroergosine on the aggressiveness of rats and mice" @default.
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- W1964366928 doi "https://doi.org/10.1016/0091-3057(89)90218-9" @default.
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