Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964379378> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1964379378 abstract "Liposome formulations with prolonged circulation time have recently been developed as a potential sustained-release drug delivery system. Data shown in this report indicate that such formulations can also be used to prolong the circulation time of proteins and peptides by conjugating them to the surface of liposomes. Increase of the circulation halflife ranged from 2- to 150-fold depending on the protein/lipid ratio of the liposomal formulation, liposome size, and the lipid composition of liposomes. Since the proteins/peptides localize on the liposome surface, instead of being entrapped inside the liposomes, they are directly available for binding to its receptor molecules and express the biological activity. This strategy has been successfully applied to two proteins with known fast clearance rate, i.e. asialofetuin and ricin A-chain. The biological activities of both proteins are preserved when they are formulated in liposomes. Incorporation of a peptide, i.e. a-factor of the yeast Saccharomyces cerevisiae, into the liposome membrane also significantly enhanced the circulation time of the peptide." @default.
- W1964379378 created "2016-06-24" @default.
- W1964379378 creator A5033300046 @default.
- W1964379378 creator A5045164231 @default.
- W1964379378 creator A5053389189 @default.
- W1964379378 creator A5060005079 @default.
- W1964379378 creator A5081460266 @default.
- W1964379378 date "1991-11-01" @default.
- W1964379378 modified "2023-10-16" @default.
- W1964379378 title "Proteins and peptides bound to long-circulating liposomes" @default.
- W1964379378 cites W1527774170 @default.
- W1964379378 cites W1546632541 @default.
- W1964379378 cites W1576884145 @default.
- W1964379378 cites W1577603732 @default.
- W1964379378 cites W1967838912 @default.
- W1964379378 cites W1970239046 @default.
- W1964379378 cites W1970855558 @default.
- W1964379378 cites W1984203974 @default.
- W1964379378 cites W1988428921 @default.
- W1964379378 cites W1989553283 @default.
- W1964379378 cites W1994570341 @default.
- W1964379378 cites W2000625719 @default.
- W1964379378 cites W2005556449 @default.
- W1964379378 cites W2012470334 @default.
- W1964379378 cites W2013410894 @default.
- W1964379378 cites W2027696154 @default.
- W1964379378 cites W2031758341 @default.
- W1964379378 cites W2037128345 @default.
- W1964379378 cites W2039884231 @default.
- W1964379378 cites W2041151042 @default.
- W1964379378 cites W2051495043 @default.
- W1964379378 cites W2054889106 @default.
- W1964379378 cites W2074969682 @default.
- W1964379378 cites W2081908460 @default.
- W1964379378 cites W2095583853 @default.
- W1964379378 cites W2117808908 @default.
- W1964379378 doi "https://doi.org/10.1016/0005-2736(91)90171-4" @default.
- W1964379378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1721540" @default.
- W1964379378 hasPublicationYear "1991" @default.
- W1964379378 type Work @default.
- W1964379378 sameAs 1964379378 @default.
- W1964379378 citedByCount "21" @default.
- W1964379378 countsByYear W19643793782013 @default.
- W1964379378 countsByYear W19643793782022 @default.
- W1964379378 crossrefType "journal-article" @default.
- W1964379378 hasAuthorship W1964379378A5033300046 @default.
- W1964379378 hasAuthorship W1964379378A5045164231 @default.
- W1964379378 hasAuthorship W1964379378A5053389189 @default.
- W1964379378 hasAuthorship W1964379378A5060005079 @default.
- W1964379378 hasAuthorship W1964379378A5081460266 @default.
- W1964379378 hasConcept C185154212 @default.
- W1964379378 hasConcept C185592680 @default.
- W1964379378 hasConcept C2779281246 @default.
- W1964379378 hasConcept C55493867 @default.
- W1964379378 hasConceptScore W1964379378C185154212 @default.
- W1964379378 hasConceptScore W1964379378C185592680 @default.
- W1964379378 hasConceptScore W1964379378C2779281246 @default.
- W1964379378 hasConceptScore W1964379378C55493867 @default.
- W1964379378 hasLocation W19643793781 @default.
- W1964379378 hasLocation W19643793782 @default.
- W1964379378 hasOpenAccess W1964379378 @default.
- W1964379378 hasPrimaryLocation W19643793781 @default.
- W1964379378 hasRelatedWork W1975557243 @default.
- W1964379378 hasRelatedWork W1986368984 @default.
- W1964379378 hasRelatedWork W2007497854 @default.
- W1964379378 hasRelatedWork W2016311081 @default.
- W1964379378 hasRelatedWork W2037882732 @default.
- W1964379378 hasRelatedWork W2082716638 @default.
- W1964379378 hasRelatedWork W2138045140 @default.
- W1964379378 hasRelatedWork W2320698385 @default.
- W1964379378 hasRelatedWork W2900281846 @default.
- W1964379378 hasRelatedWork W2953049756 @default.
- W1964379378 isParatext "false" @default.
- W1964379378 isRetracted "false" @default.
- W1964379378 magId "1964379378" @default.
- W1964379378 workType "article" @default.