FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964389712> ?p ?o ?g. }

• W1964389712 abstract "The association of HLA DRB1 alleles with susceptibility to multiple sclerosis (MS) has been consistently reported although its effect on the clinical features and disability is still unclear probably due to diversity in ethnicity and geographic location of the studied populations. The aim of the present study was to investigate the influence of HLA DRB1 alleles on the clinical features and disability of the patients with MS in Lithuania.This was a prospective study of 120 patients with MS. HLA DRB1 alleles were genotyped using the polymerase chain reaction.The first symptoms of MS in patients with HLA DRB1*15 allele manifested at younger age than in those without this allele (28.32 +/- 5.49 yrs vs. 30.94 +/- 8.43 yrs, respectively, p = 0.043). HLA DRB1*08 allele was more prevalent among relapsing-remitting (RR) MS patients than among patients with progressive course of MS (25.0% vs. 8.3%, respectively, chi^2 = 6.000, p = 0.05). MS patients with this allele had lower relapse rate than those without this allele (1.00 +/- 0.97 and 1.44 +/- 0.85, respectively, p = 0.043). Degree of disability during the last visit was lower among the patients with HLA DRB1*08 allele (EDSS score 3.15 +/- 1.95 vs. 4.49 +/- 1.96, p = 0.006), and higher among those with HLA DRB1*15 allele (EDSS score 4.60 +/- 2.10 vs.4.05 +/- 1.94, p = 0.047) compared to patients without these alleles but there were no significant associations between these alleles and the duration of the disease to disability. HLA DRB1*08 allele (OR = 0.18, 95% CI 0,039-0,8, p = 0.029) was demonstradet to be independent factor to take a longer time to reach an EDSS of 6, while HLA DRB1*01 allele (OR = 5.92, 95% CI 1,30-26,8, p = 0.021) was related in a shorter time to reach and EDSS of 6. Patients with HLA DRB1*08 allele had lower IgG index compared to patients without this allele (0.58 +/- 0.17 and 0.73 +/- 0.31, respectively, p = 0.04), and HLA DRB1*15 allele was more often found among MS patients with oligoclonal bands (OCBs) in cerebrospinal fluid than among those without OCBs (OR 2.3, CI 95% 1.017-5.301; p = 0.043).HLA DRB1*15 allele was related with an earlier manifestation of the first MS symptoms, progressive course of the disease and higher degree of disability. HLA DRB1*08 allele was more prevalent among the RR MS patients and was associated with the lower rate of relapse, degree of disability and IgG index." @default.
• W1964389712 created "2016-06-24" @default.
• W1964389712 creator A5005474836 @default.
• W1964389712 creator A5033244171 @default.
• W1964389712 creator A5045426565 @default.
• W1964389712 creator A5063268900 @default.
• W1964389712 creator A5070459484 @default.
• W1964389712 creator A5078692784 @default.
• W1964389712 creator A5091219427 @default.
• W1964389712 date "2013-07-09" @default.
• W1964389712 modified "2023-10-17" @default.
• W1964389712 title "The importance of HLA DRB1 gene allele to clinical features and disability in patients with multiple sclerosis in Lithuania" @default.
• W1964389712 cites W1549197105 @default.
• W1964389712 cites W1952380579 @default.
• W1964389712 cites W1978322957 @default.
• W1964389712 cites W1982303250 @default.
• W1964389712 cites W1998652349 @default.
• W1964389712 cites W1999841086 @default.
• W1964389712 cites W2005486769 @default.
• W1964389712 cites W2020458076 @default.
• W1964389712 cites W2031047748 @default.
• W1964389712 cites W2066784359 @default.
• W1964389712 cites W2094473949 @default.
• W1964389712 cites W2095839641 @default.
• W1964389712 cites W2100298805 @default.
• W1964389712 cites W2103231836 @default.
• W1964389712 cites W2111536363 @default.
• W1964389712 cites W2117650131 @default.
• W1964389712 cites W2139369832 @default.
• W1964389712 cites W2145434996 @default.
• W1964389712 cites W2149134458 @default.
• W1964389712 cites W2156977580 @default.
• W1964389712 cites W2163521262 @default.
• W1964389712 cites W2164371036 @default.
• W1964389712 cites W2916040650 @default.
• W1964389712 cites W4250145052 @default.
• W1964389712 doi "https://doi.org/10.1186/1471-2377-13-77" @default.
• W1964389712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3716946" @default.
• W1964389712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23837503" @default.
• W1964389712 hasPublicationYear "2013" @default.
• W1964389712 type Work @default.
• W1964389712 sameAs 1964389712 @default.
• W1964389712 citedByCount "19" @default.
• W1964389712 countsByYear W19643897122013 @default.
• W1964389712 countsByYear W19643897122014 @default.
• W1964389712 countsByYear W19643897122015 @default.
• W1964389712 countsByYear W19643897122016 @default.
• W1964389712 countsByYear W19643897122017 @default.
• W1964389712 countsByYear W19643897122018 @default.
• W1964389712 countsByYear W19643897122019 @default.
• W1964389712 countsByYear W19643897122023 @default.
• W1964389712 crossrefType "journal-article" @default.
• W1964389712 hasAuthorship W1964389712A5005474836 @default.
• W1964389712 hasAuthorship W1964389712A5033244171 @default.
• W1964389712 hasAuthorship W1964389712A5045426565 @default.
• W1964389712 hasAuthorship W1964389712A5063268900 @default.
• W1964389712 hasAuthorship W1964389712A5070459484 @default.
• W1964389712 hasAuthorship W1964389712A5078692784 @default.
• W1964389712 hasAuthorship W1964389712A5091219427 @default.
• W1964389712 hasBestOaLocation W19643897121 @default.
• W1964389712 hasConcept C104317684 @default.
• W1964389712 hasConcept C126322002 @default.
• W1964389712 hasConcept C147483822 @default.
• W1964389712 hasConcept C180754005 @default.
• W1964389712 hasConcept C188280979 @default.
• W1964389712 hasConcept C203014093 @default.
• W1964389712 hasConcept C2780640218 @default.
• W1964389712 hasConcept C2781142222 @default.
• W1964389712 hasConcept C54355233 @default.
• W1964389712 hasConcept C71924100 @default.
• W1964389712 hasConcept C86803240 @default.
• W1964389712 hasConcept C90924648 @default.
• W1964389712 hasConceptScore W1964389712C104317684 @default.
• W1964389712 hasConceptScore W1964389712C126322002 @default.
• W1964389712 hasConceptScore W1964389712C147483822 @default.
• W1964389712 hasConceptScore W1964389712C180754005 @default.
• W1964389712 hasConceptScore W1964389712C188280979 @default.
• W1964389712 hasConceptScore W1964389712C203014093 @default.
• W1964389712 hasConceptScore W1964389712C2780640218 @default.
• W1964389712 hasConceptScore W1964389712C2781142222 @default.
• W1964389712 hasConceptScore W1964389712C54355233 @default.
• W1964389712 hasConceptScore W1964389712C71924100 @default.
• W1964389712 hasConceptScore W1964389712C86803240 @default.
• W1964389712 hasConceptScore W1964389712C90924648 @default.
• W1964389712 hasIssue "1" @default.
• W1964389712 hasLocation W19643897121 @default.
• W1964389712 hasLocation W19643897122 @default.
• W1964389712 hasLocation W19643897123 @default.
• W1964389712 hasLocation W19643897124 @default.
• W1964389712 hasOpenAccess W1964389712 @default.
• W1964389712 hasPrimaryLocation W19643897121 @default.
• W1964389712 hasRelatedWork W1974526123 @default.
• W1964389712 hasRelatedWork W1990442102 @default.
• W1964389712 hasRelatedWork W1994016305 @default.
• W1964389712 hasRelatedWork W2020458076 @default.
• W1964389712 hasRelatedWork W2170606826 @default.
• W1964389712 hasRelatedWork W2370268544 @default.
• W1964389712 hasRelatedWork W2384942789 @default.
• W1964389712 hasRelatedWork W2479660101 @default.
• W1964389712 hasRelatedWork W3194384404 @default.

• next