FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964397946> ?p ?o ?g. }

• W1964397946 endingPage "134" @default.
• W1964397946 startingPage "129" @default.
• W1964397946 abstract "Several immunodominant B and T cell epitopes of the P. falciparum blood stage antigen Pf155/RESA, a vaccine candidate, are located in the central (5') and C-terminal (3') invariant repeat regions of the molecule. Here we have attempted to functionally analyze human T cell responses to some of the T cell epitopes. For this purpose short synthetic peptides corresponding to these epitopes were used to study the induction of in vitro expression of IL-4 mRNA, IFN-gamma secretion, proliferation and B cell help for antibody production. In individual malaria immune donors these different T cell activities were not correlated. The findings emphasize the importance of examining multiple parameters of T cell activation when estimating the total proportion of individuals responding to a defined antigen. IL-4 mRNA was expressed in activated T cells of donors who had elevated serum concentrations of antibodies to the peptide used for T cell activation. These results suggest the involvement of IL-4 producing T helper cells in the induction of Pf155/RESA specific antibody production in individuals in which immunity has been induced by natural infection. Taken together, these findings also suggest that functionally distinct CD4+ T cells occur in humans similarly to what has been described in mice. In further experiments, we have also attempted to establish MHC class II restriction of the immune response to these epitopes at the level of the donor populations. When studying monozygotic twins, antibody responses to Pf155/RESA derived peptides and some of the T cell responses could be paired within the twin pairs, indicating a genetic regulation of their B cell responses. Whether or not this regulation reflects MHC class II restriction, or other factors needs to be elucidated." @default.
• W1964397946 created "2016-06-24" @default.
• W1964397946 creator A5001304391 @default.
• W1964397946 creator A5013832267 @default.
• W1964397946 creator A5017348677 @default.
• W1964397946 creator A5050207643 @default.
• W1964397946 creator A5059715613 @default.
• W1964397946 creator A5071052420 @default.
• W1964397946 creator A5083935487 @default.
• W1964397946 creator A5089502578 @default.
• W1964397946 date "1990-08-01" @default.
• W1964397946 modified "2023-10-01" @default.
• W1964397946 title "Characterization of regulatory T cell responses to defined immunodominant T cell epitopes of the Plasmodium falciparum antigen Pf155/RESA" @default.
• W1964397946 cites W1586182515 @default.
• W1964397946 cites W1596098937 @default.
• W1964397946 cites W1965771218 @default.
• W1964397946 cites W1966037431 @default.
• W1964397946 cites W1973419885 @default.
• W1964397946 cites W1977188544 @default.
• W1964397946 cites W1986858811 @default.
• W1964397946 cites W2003600326 @default.
• W1964397946 cites W2017547989 @default.
• W1964397946 cites W2074407786 @default.
• W1964397946 cites W2081721927 @default.
• W1964397946 cites W2082769143 @default.
• W1964397946 cites W2084982748 @default.
• W1964397946 cites W2089008531 @default.
• W1964397946 cites W2090220726 @default.
• W1964397946 cites W2118636061 @default.
• W1964397946 cites W2119819881 @default.
• W1964397946 cites W2397118511 @default.
• W1964397946 cites W2440053044 @default.
• W1964397946 cites W25458480 @default.
• W1964397946 doi "https://doi.org/10.1016/0165-2478(90)90103-w" @default.
• W1964397946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1704342" @default.
• W1964397946 hasPublicationYear "1990" @default.
• W1964397946 type Work @default.
• W1964397946 sameAs 1964397946 @default.
• W1964397946 citedByCount "18" @default.
• W1964397946 countsByYear W19643979462012 @default.
• W1964397946 countsByYear W19643979462023 @default.
• W1964397946 crossrefType "journal-article" @default.
• W1964397946 hasAuthorship W1964397946A5001304391 @default.
• W1964397946 hasAuthorship W1964397946A5013832267 @default.
• W1964397946 hasAuthorship W1964397946A5017348677 @default.
• W1964397946 hasAuthorship W1964397946A5050207643 @default.
• W1964397946 hasAuthorship W1964397946A5059715613 @default.
• W1964397946 hasAuthorship W1964397946A5071052420 @default.
• W1964397946 hasAuthorship W1964397946A5083935487 @default.
• W1964397946 hasAuthorship W1964397946A5089502578 @default.
• W1964397946 hasConcept C147483822 @default.
• W1964397946 hasConcept C153911025 @default.
• W1964397946 hasConcept C159047783 @default.
• W1964397946 hasConcept C159654299 @default.
• W1964397946 hasConcept C195616568 @default.
• W1964397946 hasConcept C203014093 @default.
• W1964397946 hasConcept C2776090121 @default.
• W1964397946 hasConcept C2778048844 @default.
• W1964397946 hasConcept C2778371730 @default.
• W1964397946 hasConcept C2778453870 @default.
• W1964397946 hasConcept C86803240 @default.
• W1964397946 hasConcept C8891405 @default.
• W1964397946 hasConceptScore W1964397946C147483822 @default.
• W1964397946 hasConceptScore W1964397946C153911025 @default.
• W1964397946 hasConceptScore W1964397946C159047783 @default.
• W1964397946 hasConceptScore W1964397946C159654299 @default.
• W1964397946 hasConceptScore W1964397946C195616568 @default.
• W1964397946 hasConceptScore W1964397946C203014093 @default.
• W1964397946 hasConceptScore W1964397946C2776090121 @default.
• W1964397946 hasConceptScore W1964397946C2778048844 @default.
• W1964397946 hasConceptScore W1964397946C2778371730 @default.
• W1964397946 hasConceptScore W1964397946C2778453870 @default.
• W1964397946 hasConceptScore W1964397946C86803240 @default.
• W1964397946 hasConceptScore W1964397946C8891405 @default.
• W1964397946 hasIssue "1-3" @default.
• W1964397946 hasLocation W19643979461 @default.
• W1964397946 hasLocation W19643979462 @default.
• W1964397946 hasOpenAccess W1964397946 @default.
• W1964397946 hasPrimaryLocation W19643979461 @default.
• W1964397946 hasRelatedWork W1484759019 @default.
• W1964397946 hasRelatedWork W1604248381 @default.
• W1964397946 hasRelatedWork W1872459230 @default.
• W1964397946 hasRelatedWork W2021845296 @default.
• W1964397946 hasRelatedWork W2050101049 @default.
• W1964397946 hasRelatedWork W2061344919 @default.
• W1964397946 hasRelatedWork W2130792233 @default.
• W1964397946 hasRelatedWork W2220102944 @default.
• W1964397946 hasRelatedWork W2313745184 @default.
• W1964397946 hasRelatedWork W4244618944 @default.
• W1964397946 hasVolume "25" @default.
• W1964397946 isParatext "false" @default.
• W1964397946 isRetracted "false" @default.
• W1964397946 magId "1964397946" @default.
• W1964397946 workType "article" @default.