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• W1964405764 abstract "Ten women and 10 men consumed 50 g daily of probiotic sausage (Lactobacillus paracasei LTH 2579) over 5 weeks, after a control period with conventional sausage. Four venous blood samples were taken: at the start of the study, at the end of each period, and after 2 weeks of the probiotic sausage period. Stool samples were collected on the 3rd and 9th day of defined diet at the end of each period and during a washout post-period. Total cholesterol, HDL and LDL cholesterol, triacylglycerides, antibodies against oxidized LDL, and some immunological parameters were analysed. In faecal samples, there was a statistically significant increase in the numbers of L. paracasei LTH 2579, but not in all volunteers. There was no significant influence of the probiotics on serum concentration of different cholesterol fractions and triacylglycerides. At the end of the intervention with probiotic bacteria, a significantly higher titre of antibodies against oxidized LDL was measured. The changes in immunological parameters were within physiological variation. The values of CD4 (T-helper)-lymphocytes increased after 2 weeks of supplementation with L. paracasei, but decreased to the basic value by the end of the study. A significantly positive correlation between the numbers of L. paracasei in the stool and the percentage of cells expressing CD4 was found. The expression of CD54 (ICAM-1) on lymphocytes decreased significantly after consuming probiotic sausage. The phagocytosis index of granulocytes was significantly enhanced at the end of the probiotic period as compared with controls. These findings provide evidence that L. paracasei LTH 2579 applied via sausage modulates various aspects of host immunity. Le tractus intestinal est plus ou moins adapte a une supplementation journaliere de bacteries lactiques vivantes. Le sujet de cette etude est de detecter une influence de Lactobacillus paracasei dans le regime alimentaire sur les lipides sanguins et le systeme immunitaire. Pour cela, 10 femmes et 10 hommes consomment 50g/jour de saucisse probiotique (Lactobacillus paracasei LTH 2579) pendant 5 semaines apres une periode de controle avec une saucisse conventionnelle. 4 echantillons sanguins veineux sont pris: au debut de l'etude, a la fin de chaque periode et apres 2 semaines de la periode probiotique. Des echantillons de selles sont aussi collectes. Le cholesterol total, HDL et LDL, les triacylglycerides, les anticorps contre les LDL oxydees et quelques parametres immunologiques sont analyses." @default.
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• W1964405764 date "2002-01-01" @default.
• W1964405764 modified "2023-09-27" @default.
• W1964405764 title "Influence of probiotic sausage (Lactobacillus paracasei) on blood lipids and immunological parameters of healthy volunteers" @default.
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