FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964407211> ?p ?o ?g. }

• W1964407211 endingPage "1050" @default.
• W1964407211 startingPage "1036" @default.
• W1964407211 abstract "Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which induces a cellular response, remains unclear. This study investigates the influence of LMHF loading, applied using a custom designed bioreactor, on bone adaptation in an explanted trabecular bone model, which isolated the bone and marrow. Bone adaptation was investigated by performing micro CT scans pre and post experimental LMHF loading, using image registration techniques. Computational fluids dynamic models were generated using the pre-experiment scans to characterise the mechanical stimuli imposed by the loading regime prior to adaptation. Results here demonstrate a significant increase in bone formation in the LMHF loaded group compared to static controls and media flow groups. The calculated shear stress in the marrow was between 0.575 and 0.7 Pa, which is within the range of stimuli known to induce osteogenesis by bone marrow mesenchymal stem cells in vitro. Interestingly, a correlation was found between the bone formation balance (bone formation/resorption), trabecular number, trabecular spacing, mineral resorption rate, bone resorption rate and mean shear stresses. The results of this study suggest that the magnitude of the shear stresses generated due to LMHF loading in the explanted bone cores has a contributory role in the formation of trabecular bone and improvement in bone architecture parameters." @default.
• W1964407211 created "2016-06-24" @default.
• W1964407211 creator A5020169130 @default.
• W1964407211 creator A5020764414 @default.
• W1964407211 creator A5025142881 @default.
• W1964407211 creator A5037015205 @default.
• W1964407211 creator A5053368765 @default.
• W1964407211 creator A5073871945 @default.
• W1964407211 creator A5080824158 @default.
• W1964407211 creator A5081048345 @default.
• W1964407211 date "2014-10-04" @default.
• W1964407211 modified "2023-10-12" @default.
• W1964407211 title "Mechanical Stimulation of Bone Marrow In Situ Induces Bone Formation in Trabecular Explants" @default.
• W1964407211 cites W122585317 @default.
• W1964407211 cites W1536179852 @default.
• W1964407211 cites W1628998952 @default.
• W1964407211 cites W1944337009 @default.
• W1964407211 cites W1966033769 @default.
• W1964407211 cites W1969724199 @default.
• W1964407211 cites W1970291858 @default.
• W1964407211 cites W1973907417 @default.
• W1964407211 cites W1976824675 @default.
• W1964407211 cites W1977946489 @default.
• W1964407211 cites W1977950302 @default.
• W1964407211 cites W1982195212 @default.
• W1964407211 cites W1987176983 @default.
• W1964407211 cites W1991334000 @default.
• W1964407211 cites W1993500165 @default.
• W1964407211 cites W1996644745 @default.
• W1964407211 cites W1997083272 @default.
• W1964407211 cites W2001149002 @default.
• W1964407211 cites W2005387309 @default.
• W1964407211 cites W2011828467 @default.
• W1964407211 cites W2013708245 @default.
• W1964407211 cites W2013785685 @default.
• W1964407211 cites W2020300493 @default.
• W1964407211 cites W2022057411 @default.
• W1964407211 cites W2027829165 @default.
• W1964407211 cites W2029810059 @default.
• W1964407211 cites W2034403497 @default.
• W1964407211 cites W2039396493 @default.
• W1964407211 cites W2045059538 @default.
• W1964407211 cites W2049592557 @default.
• W1964407211 cites W2054361639 @default.
• W1964407211 cites W2061454066 @default.
• W1964407211 cites W2086859574 @default.
• W1964407211 cites W2090348823 @default.
• W1964407211 cites W2098416899 @default.
• W1964407211 cites W2099699245 @default.
• W1964407211 cites W2112079038 @default.
• W1964407211 cites W2112657737 @default.
• W1964407211 cites W2114495080 @default.
• W1964407211 cites W2123666788 @default.
• W1964407211 cites W2130804510 @default.
• W1964407211 cites W2131717731 @default.
• W1964407211 cites W2138889138 @default.
• W1964407211 cites W2139301465 @default.
• W1964407211 cites W2146046277 @default.
• W1964407211 cites W2154399304 @default.
• W1964407211 cites W2157862070 @default.
• W1964407211 cites W2164319357 @default.
• W1964407211 cites W2168894784 @default.
• W1964407211 cites W2169237541 @default.
• W1964407211 cites W2171705946 @default.
• W1964407211 cites W2174322495 @default.
• W1964407211 cites W2253282519 @default.
• W1964407211 cites W2338251223 @default.
• W1964407211 cites W4249727000 @default.
• W1964407211 cites W4376453233 @default.
• W1964407211 doi "https://doi.org/10.1007/s10439-014-1135-0" @default.
• W1964407211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25281407" @default.
• W1964407211 hasPublicationYear "2014" @default.
• W1964407211 type Work @default.
• W1964407211 sameAs 1964407211 @default.
• W1964407211 citedByCount "34" @default.
• W1964407211 countsByYear W19644072112014 @default.
• W1964407211 countsByYear W19644072112015 @default.
• W1964407211 countsByYear W19644072112016 @default.
• W1964407211 countsByYear W19644072112017 @default.
• W1964407211 countsByYear W19644072112018 @default.
• W1964407211 countsByYear W19644072112019 @default.
• W1964407211 countsByYear W19644072112020 @default.
• W1964407211 countsByYear W19644072112021 @default.
• W1964407211 countsByYear W19644072112023 @default.
• W1964407211 crossrefType "journal-article" @default.
• W1964407211 hasAuthorship W1964407211A5020169130 @default.
• W1964407211 hasAuthorship W1964407211A5020764414 @default.
• W1964407211 hasAuthorship W1964407211A5025142881 @default.
• W1964407211 hasAuthorship W1964407211A5037015205 @default.
• W1964407211 hasAuthorship W1964407211A5053368765 @default.
• W1964407211 hasAuthorship W1964407211A5073871945 @default.
• W1964407211 hasAuthorship W1964407211A5080824158 @default.
• W1964407211 hasAuthorship W1964407211A5081048345 @default.
• W1964407211 hasBestOaLocation W19644072112 @default.
• W1964407211 hasConcept C105702510 @default.
• W1964407211 hasConcept C126838900 @default.
• W1964407211 hasConcept C134018914 @default.
• W1964407211 hasConcept C136229726 @default.

• next