Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964411425> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1964411425 endingPage "53" @default.
- W1964411425 startingPage "47" @default.
- W1964411425 abstract "We studied the effects of high-dose methotrexate on heterotopic bone formation induced by implants of demineralized bone matrix in the abdominal wall of-growing rats. Methotrexate induced an arrest in normal weight gain of the animals, more pronounced the younger the animals were. The youngest animals had reduced ash weight and decreased isotope uptake in the tibiae and teeth. However, implants from these animals, given methotrexate 10 days before implantation of bone matrix, had a 33 per cent increase in ash content. When methotrexate was given at, or 10 days after, implantation, heterotopic bone formation was reduced by 40 and 22 per cent, respectively, whereas orthotopic bone was considerably less affected in these older animals. In a second experiment, no difference in elimination rates of 45Ca between methotrexate-treated and control rats in implants, teeth, or tibiae were found.It appears that a less detrimental effect of methotrexate on new bone formation can be expected if the drug is given before, or a substantial period after, surgery requiring bone formation for healing." @default.
- W1964411425 created "2016-06-24" @default.
- W1964411425 creator A5002093555 @default.
- W1964411425 creator A5007027360 @default.
- W1964411425 creator A5067152237 @default.
- W1964411425 date "1987-01-01" @default.
- W1964411425 modified "2023-10-02" @default.
- W1964411425 title "Methotrexate effects on heterotopic bone in rats" @default.
- W1964411425 cites W1974031166 @default.
- W1964411425 cites W1974907966 @default.
- W1964411425 cites W1992141537 @default.
- W1964411425 cites W1997959817 @default.
- W1964411425 cites W2005097199 @default.
- W1964411425 cites W2010822924 @default.
- W1964411425 cites W2026058273 @default.
- W1964411425 cites W2029744368 @default.
- W1964411425 cites W2074889809 @default.
- W1964411425 cites W2095722175 @default.
- W1964411425 cites W2227246587 @default.
- W1964411425 cites W2263804222 @default.
- W1964411425 cites W2317833459 @default.
- W1964411425 doi "https://doi.org/10.3109/17453678709146342" @default.
- W1964411425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3577740" @default.
- W1964411425 hasPublicationYear "1987" @default.
- W1964411425 type Work @default.
- W1964411425 sameAs 1964411425 @default.
- W1964411425 citedByCount "15" @default.
- W1964411425 countsByYear W19644114252014 @default.
- W1964411425 countsByYear W19644114252017 @default.
- W1964411425 crossrefType "journal-article" @default.
- W1964411425 hasAuthorship W1964411425A5002093555 @default.
- W1964411425 hasAuthorship W1964411425A5007027360 @default.
- W1964411425 hasAuthorship W1964411425A5067152237 @default.
- W1964411425 hasConcept C105702510 @default.
- W1964411425 hasConcept C126322002 @default.
- W1964411425 hasConcept C134018914 @default.
- W1964411425 hasConcept C141071460 @default.
- W1964411425 hasConcept C2780550940 @default.
- W1964411425 hasConcept C2780650075 @default.
- W1964411425 hasConcept C2781059491 @default.
- W1964411425 hasConcept C2993291840 @default.
- W1964411425 hasConcept C2993697008 @default.
- W1964411425 hasConcept C3019724422 @default.
- W1964411425 hasConcept C71924100 @default.
- W1964411425 hasConceptScore W1964411425C105702510 @default.
- W1964411425 hasConceptScore W1964411425C126322002 @default.
- W1964411425 hasConceptScore W1964411425C134018914 @default.
- W1964411425 hasConceptScore W1964411425C141071460 @default.
- W1964411425 hasConceptScore W1964411425C2780550940 @default.
- W1964411425 hasConceptScore W1964411425C2780650075 @default.
- W1964411425 hasConceptScore W1964411425C2781059491 @default.
- W1964411425 hasConceptScore W1964411425C2993291840 @default.
- W1964411425 hasConceptScore W1964411425C2993697008 @default.
- W1964411425 hasConceptScore W1964411425C3019724422 @default.
- W1964411425 hasConceptScore W1964411425C71924100 @default.
- W1964411425 hasIssue "1" @default.
- W1964411425 hasLocation W19644114251 @default.
- W1964411425 hasLocation W19644114252 @default.
- W1964411425 hasOpenAccess W1964411425 @default.
- W1964411425 hasPrimaryLocation W19644114251 @default.
- W1964411425 hasRelatedWork W1966504330 @default.
- W1964411425 hasRelatedWork W1968920178 @default.
- W1964411425 hasRelatedWork W1974041167 @default.
- W1964411425 hasRelatedWork W1979139803 @default.
- W1964411425 hasRelatedWork W2001650559 @default.
- W1964411425 hasRelatedWork W2037631372 @default.
- W1964411425 hasRelatedWork W2040058909 @default.
- W1964411425 hasRelatedWork W2312827319 @default.
- W1964411425 hasRelatedWork W2409838344 @default.
- W1964411425 hasRelatedWork W2748952813 @default.
- W1964411425 hasVolume "58" @default.
- W1964411425 isParatext "false" @default.
- W1964411425 isRetracted "false" @default.
- W1964411425 magId "1964411425" @default.
- W1964411425 workType "article" @default.