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- W1964415090 abstract "We have previously reported the existence and activity of a collagen-like, low molecular weight, suppressive peptide complex in patients with greater than 40% BSA burns. Since Clq participates in the inflammatory response and contains a collagen-like sequence, we have tested, in vitro, the putative generation and immunologic activity of Clq peptide fragments under physical conditions present in burned patients. Nanogram quantities of heat- and enzyme-generated fragments of Clq were shown to be suppressive in vitro to neutrophil chemotaxis, and the mixed lymphocyte response (MLR). The addition of lymphocytes pretreated with Clq fragments suppressed ongoing MLR, indicating the activation of suppressor cells by the peptides. Rabbit anti- Clq globulin was found to reduce the suppressive activity of the collagen-like suppressor which was isolated from human burn sera. Our results therefore suggest that Clq may be an early source of degradation peptides which have strong nonspecific immunosuppressive activity following thermal injuries." @default.
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- W1964415090 date "1987-02-01" @default.
- W1964415090 modified "2023-10-18" @default.
- W1964415090 title "The Immunosuppressive Activity of Clq Degradation Peptides" @default.
- W1964415090 doi "https://doi.org/10.1097/00005373-198702000-00003" @default.
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