Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964420128> ?p ?o ?g. }
- W1964420128 endingPage "5600" @default.
- W1964420128 startingPage "5592" @default.
- W1964420128 abstract "flbA encodes an Aspergillus nidulans RGS (regulator of G protein signaling) domain protein that antagonizes FadA (G(i)alpha-subunit of heterotrimeric G protein)-mediated growth signaling to allow asexual development. We previously defined and characterized five suppressors of flbA (sfa) loss-of-function mutations and showed that one suppressor (sfaB) resulted from a novel dominant-negative allele of fadA. In this report we show that a second suppressor gene (sfaD) is predicted to encode the beta subunit of a heterotrimeric G protein. Deletion of sfaD suppressed all defects resulting from complete loss-of-flbA function mutations, caused a hyperactive sporulation phenotype and severely reduced vegetative growth. However, the sfaD deletion could not suppress the growth activation caused by dominant-activating fadA alleles, indicating that constitutively active FadA can cause proliferative growth in the absence of Gbetagamma signaling. We propose that SfaD and FadA are both positive growth regulators with partially overlapping functions and that FlbA has an important role in controlling the activities of both proteins. Inactivation of signaling events stimulated by both components of the heterotrimeric G protein is essential for both sexual and asexual sporulation." @default.
- W1964420128 created "2016-06-24" @default.
- W1964420128 creator A5007386207 @default.
- W1964420128 creator A5070496886 @default.
- W1964420128 creator A5080517747 @default.
- W1964420128 date "1999-10-15" @default.
- W1964420128 modified "2023-10-18" @default.
- W1964420128 title "The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation" @default.
- W1964420128 cites W1591529270 @default.
- W1964420128 cites W1614895539 @default.
- W1964420128 cites W17439892 @default.
- W1964420128 cites W1943685035 @default.
- W1964420128 cites W1953744040 @default.
- W1964420128 cites W1967717217 @default.
- W1964420128 cites W1975112692 @default.
- W1964420128 cites W1992066867 @default.
- W1964420128 cites W199630822 @default.
- W1964420128 cites W1997731523 @default.
- W1964420128 cites W2008711836 @default.
- W1964420128 cites W2015650792 @default.
- W1964420128 cites W2027914921 @default.
- W1964420128 cites W2029445497 @default.
- W1964420128 cites W2029552635 @default.
- W1964420128 cites W2036931150 @default.
- W1964420128 cites W2042952021 @default.
- W1964420128 cites W2043095804 @default.
- W1964420128 cites W2052280808 @default.
- W1964420128 cites W2054004023 @default.
- W1964420128 cites W2063231382 @default.
- W1964420128 cites W2067102790 @default.
- W1964420128 cites W2071242185 @default.
- W1964420128 cites W2071357103 @default.
- W1964420128 cites W2093516457 @default.
- W1964420128 cites W2099290115 @default.
- W1964420128 cites W2110458673 @default.
- W1964420128 cites W2115464623 @default.
- W1964420128 cites W2136906322 @default.
- W1964420128 cites W2150525179 @default.
- W1964420128 cites W2398122710 @default.
- W1964420128 cites W252346336 @default.
- W1964420128 cites W74173866 @default.
- W1964420128 doi "https://doi.org/10.1093/emboj/18.20.5592" @default.
- W1964420128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171627" @default.
- W1964420128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10523303" @default.
- W1964420128 hasPublicationYear "1999" @default.
- W1964420128 type Work @default.
- W1964420128 sameAs 1964420128 @default.
- W1964420128 citedByCount "144" @default.
- W1964420128 countsByYear W19644201282012 @default.
- W1964420128 countsByYear W19644201282013 @default.
- W1964420128 countsByYear W19644201282014 @default.
- W1964420128 countsByYear W19644201282015 @default.
- W1964420128 countsByYear W19644201282016 @default.
- W1964420128 countsByYear W19644201282017 @default.
- W1964420128 countsByYear W19644201282018 @default.
- W1964420128 countsByYear W19644201282019 @default.
- W1964420128 countsByYear W19644201282020 @default.
- W1964420128 countsByYear W19644201282021 @default.
- W1964420128 countsByYear W19644201282022 @default.
- W1964420128 countsByYear W19644201282023 @default.
- W1964420128 crossrefType "journal-article" @default.
- W1964420128 hasAuthorship W1964420128A5007386207 @default.
- W1964420128 hasAuthorship W1964420128A5070496886 @default.
- W1964420128 hasAuthorship W1964420128A5080517747 @default.
- W1964420128 hasBestOaLocation W19644201282 @default.
- W1964420128 hasConcept C104292427 @default.
- W1964420128 hasConcept C104317684 @default.
- W1964420128 hasConcept C139407321 @default.
- W1964420128 hasConcept C143065580 @default.
- W1964420128 hasConcept C150194340 @default.
- W1964420128 hasConcept C158448853 @default.
- W1964420128 hasConcept C2776923806 @default.
- W1964420128 hasConcept C2910135453 @default.
- W1964420128 hasConcept C54355233 @default.
- W1964420128 hasConcept C62478195 @default.
- W1964420128 hasConcept C80631254 @default.
- W1964420128 hasConcept C83730767 @default.
- W1964420128 hasConcept C86803240 @default.
- W1964420128 hasConcept C95444343 @default.
- W1964420128 hasConceptScore W1964420128C104292427 @default.
- W1964420128 hasConceptScore W1964420128C104317684 @default.
- W1964420128 hasConceptScore W1964420128C139407321 @default.
- W1964420128 hasConceptScore W1964420128C143065580 @default.
- W1964420128 hasConceptScore W1964420128C150194340 @default.
- W1964420128 hasConceptScore W1964420128C158448853 @default.
- W1964420128 hasConceptScore W1964420128C2776923806 @default.
- W1964420128 hasConceptScore W1964420128C2910135453 @default.
- W1964420128 hasConceptScore W1964420128C54355233 @default.
- W1964420128 hasConceptScore W1964420128C62478195 @default.
- W1964420128 hasConceptScore W1964420128C80631254 @default.
- W1964420128 hasConceptScore W1964420128C83730767 @default.
- W1964420128 hasConceptScore W1964420128C86803240 @default.
- W1964420128 hasConceptScore W1964420128C95444343 @default.
- W1964420128 hasIssue "20" @default.
- W1964420128 hasLocation W19644201281 @default.
- W1964420128 hasLocation W19644201282 @default.
- W1964420128 hasLocation W19644201283 @default.
- W1964420128 hasLocation W19644201284 @default.