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• W1964420796 abstract "Functional mapping and microstimulation studies suggest that recovery after stroke damage can be attributed to surviving brain regions taking on the functional roles of lost tissues. Although this model is well supported by data, it is not clear how activity in single neurons is altered in relation to cortical functional maps. It is conceivable that individual surviving neurons could adopt new roles at the expense of their usual function. Alternatively, neurons that contribute to recovery may take on multiple functions and exhibit a wider repertoire of neuronal processing. In vivo two-photon calcium imaging was used in adult mice within reorganized forelimb and hindlimb somatosensory functional maps to determine how the response properties of individual neurons and glia were altered during recovery from ischemic damage over a period of 2-8 weeks. Single-cell calcium imaging revealed that the limb selectivity of individual neurons was altered during recovery from ischemia, such that neurons normally selective for a single contralateral limb processed information from multiple limbs. Altered limb selectivity was most prominent in border regions between stroke-altered forelimb and hindlimb macroscopic map representations, and peaked 1 month after the targeted insult. Two months after stroke, individual neurons near the center of reorganized functional areas became more selective for a preferred limb. These previously unreported forms of plasticity indicate that in adult animals, seemingly hardwired cortical neurons first adopt wider functional roles as they develop strategies to compensate for loss of specific sensory modalities after forms of brain damage such as stroke." @default.
• W1964420796 created "2016-06-24" @default.
• W1964420796 creator A5072258662 @default.
• W1964420796 creator A5074285789 @default.
• W1964420796 date "2008-06-25" @default.
• W1964420796 modified "2023-09-25" @default.
• W1964420796 title "In Vivo Calcium Imaging Reveals Functional Rewiring of Single Somatosensory Neurons after Stroke" @default.
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• W1964420796 doi "https://doi.org/10.1523/jneurosci.0622-08.2008" @default.
• W1964420796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6670410" @default.
• W1964420796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18579732" @default.
• W1964420796 hasPublicationYear "2008" @default.

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