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• W1964421036 abstract "Caspase-3 is a critical apoptosis-promoting element but its status during stepwise gastrocarcinogenesis needs to be further clarified.By the use of frozen tissue microarrays constructed with the tissue spots cored from defined histological regions in tissue blocks, the pattern of caspase-3 expression in noncancerous, premalignant (atrophic gastritis and intestinal metaplasia) tissue and cancer spots were analyzed under the same experimental conditions by the methods of immunohistochemistry and mRNA-in situ hybridization.Caspase-3 was expressed in all 34 of the noncancerous mucosa (100%), in 16 of the 17 premalignant tissues (94.1%) and in 15 of the 48 gastric cancers (31.3%). The incidences of caspase-3 detection were significantly different (p<0.01) between noncancerous mucosa and intestinal as well as diffuse gastric cancers.Down-regulated caspase-3 is closely correlated with gastric cancer formation and would be a potential indicator of tumor formation and progression. Helicobacter pylori (H. pylori; Hp) infection is but not the only one element responsible to the enhanced caspase-3 expression in gastric epithelia." @default.
• W1964421036 created "2016-06-24" @default.
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• W1964421036 date "2006-01-01" @default.
• W1964421036 modified "2023-10-12" @default.
• W1964421036 title "Differential caspase-3 expression in noncancerous, premalignant and cancer tissues of stomach and its clinical implication" @default.
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• W1964421036 doi "https://doi.org/10.1016/j.cdp.2006.02.004" @default.
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