Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964427001> ?p ?o ?g. }
- W1964427001 endingPage "427" @default.
- W1964427001 startingPage "419" @default.
- W1964427001 abstract "Accumulating evidence indicates that breast cancer is caused by cancer stem cells and cure of breast cancer requires eradication of breast cancer stem cells. Previous studies with leukemia stem cells have shown that NF-kappaB pathway is important for leukemia stem cell survival. In this study, by using MCF7 sphere cells as model of breast cancer stem-like cells, we evaluated the effect of NF-kappaB pathway specific inhibitors on human breast cancer MCF7 sphere cells. Three inhibitors including parthenolide (PTL), pyrrolidinedithiocarbamate (PDTC) and its analog diethyldithiocarbamate (DETC) were found to preferentially inhibit MCF7 sphere cell proliferation. These compounds also showed preferential inhibition in term of proliferation and colony formation on MCF7 side population (SP) cells, a small fraction of MCF7 cells known to enrich in breast cancer stem-like cells. The preferential inhibition effect of these compounds was due to inhibition of the NF-kappaB activity in both MCF7 sphere and MCF7 cells, with higher inhibition effect on MCF7 sphere cells than on MCF7 cells. PDTC was further evaluated in vivo and showed significant tumor growth inhibition alone but had better tumor growth inhibition in combination with paclitaxel in the mouse xenograft model than either PDTC or paclitaxel alone. This study suggests that breast cancer stem-like cells could be selectively inhibited by targeting signaling pathways important for breast cancer stem-like cells." @default.
- W1964427001 created "2016-06-24" @default.
- W1964427001 creator A5012245215 @default.
- W1964427001 creator A5032006171 @default.
- W1964427001 creator A5040472620 @default.
- W1964427001 creator A5042973046 @default.
- W1964427001 creator A5085160256 @default.
- W1964427001 creator A5088392224 @default.
- W1964427001 date "2007-10-27" @default.
- W1964427001 modified "2023-09-24" @default.
- W1964427001 title "NF-κB pathway inhibitors preferentially inhibit breast cancer stem-like cells" @default.
- W1964427001 cites W1262485082 @default.
- W1964427001 cites W1483167997 @default.
- W1964427001 cites W1562190372 @default.
- W1964427001 cites W1965124339 @default.
- W1964427001 cites W1970863086 @default.
- W1964427001 cites W1971732321 @default.
- W1964427001 cites W1987239635 @default.
- W1964427001 cites W1988356885 @default.
- W1964427001 cites W1991449455 @default.
- W1964427001 cites W1992724342 @default.
- W1964427001 cites W2000682995 @default.
- W1964427001 cites W2003466100 @default.
- W1964427001 cites W2009886857 @default.
- W1964427001 cites W2010317454 @default.
- W1964427001 cites W2011447408 @default.
- W1964427001 cites W2011817273 @default.
- W1964427001 cites W2012495753 @default.
- W1964427001 cites W2023427658 @default.
- W1964427001 cites W2024964682 @default.
- W1964427001 cites W2035154687 @default.
- W1964427001 cites W2038554369 @default.
- W1964427001 cites W2046788126 @default.
- W1964427001 cites W2048639599 @default.
- W1964427001 cites W2050300062 @default.
- W1964427001 cites W2050433177 @default.
- W1964427001 cites W2054473882 @default.
- W1964427001 cites W2056598800 @default.
- W1964427001 cites W2058399266 @default.
- W1964427001 cites W2062069198 @default.
- W1964427001 cites W2064437405 @default.
- W1964427001 cites W2090982381 @default.
- W1964427001 cites W2102085111 @default.
- W1964427001 cites W2113704788 @default.
- W1964427001 cites W2118566193 @default.
- W1964427001 cites W2127617517 @default.
- W1964427001 cites W2129925845 @default.
- W1964427001 cites W2134959033 @default.
- W1964427001 cites W2135331361 @default.
- W1964427001 cites W2137734141 @default.
- W1964427001 cites W2137956382 @default.
- W1964427001 cites W2140254135 @default.
- W1964427001 cites W2143995836 @default.
- W1964427001 cites W2145260509 @default.
- W1964427001 cites W2149609961 @default.
- W1964427001 cites W2155596800 @default.
- W1964427001 cites W2159414724 @default.
- W1964427001 cites W2159567970 @default.
- W1964427001 cites W2163292580 @default.
- W1964427001 cites W2164977083 @default.
- W1964427001 cites W2165803132 @default.
- W1964427001 cites W2169585027 @default.
- W1964427001 cites W2316386966 @default.
- W1964427001 cites W2409723816 @default.
- W1964427001 cites W4232099705 @default.
- W1964427001 cites W4232678241 @default.
- W1964427001 cites W4313347901 @default.
- W1964427001 cites W51687130 @default.
- W1964427001 doi "https://doi.org/10.1007/s10549-007-9798-y" @default.
- W1964427001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3320112" @default.
- W1964427001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17965935" @default.
- W1964427001 hasPublicationYear "2007" @default.
- W1964427001 type Work @default.
- W1964427001 sameAs 1964427001 @default.
- W1964427001 citedByCount "181" @default.
- W1964427001 countsByYear W19644270012012 @default.
- W1964427001 countsByYear W19644270012013 @default.
- W1964427001 countsByYear W19644270012014 @default.
- W1964427001 countsByYear W19644270012015 @default.
- W1964427001 countsByYear W19644270012016 @default.
- W1964427001 countsByYear W19644270012017 @default.
- W1964427001 countsByYear W19644270012018 @default.
- W1964427001 countsByYear W19644270012019 @default.
- W1964427001 countsByYear W19644270012020 @default.
- W1964427001 countsByYear W19644270012021 @default.
- W1964427001 countsByYear W19644270012022 @default.
- W1964427001 countsByYear W19644270012023 @default.
- W1964427001 crossrefType "journal-article" @default.
- W1964427001 hasAuthorship W1964427001A5012245215 @default.
- W1964427001 hasAuthorship W1964427001A5032006171 @default.
- W1964427001 hasAuthorship W1964427001A5040472620 @default.
- W1964427001 hasAuthorship W1964427001A5042973046 @default.
- W1964427001 hasAuthorship W1964427001A5085160256 @default.
- W1964427001 hasAuthorship W1964427001A5088392224 @default.
- W1964427001 hasBestOaLocation W19644270012 @default.
- W1964427001 hasConcept C121608353 @default.
- W1964427001 hasConcept C126322002 @default.
- W1964427001 hasConcept C190283241 @default.