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- W1964430250 abstract "Nous rapportons un cas de déficit acquis, transitoire et isolé en facteur VII (FVII) post-traumatique. Un garçon de 16 ans était victime d'un accident de la voie publique avec traumatisme crânien grave. Il présentait un hématome intracérébral (5 cm) et une contusion frontale. Le taux de prothrombine initial était normal. En quelques heures, des anomalies profondes de la coagulation apparaissaient, non corrigées par l'administration de plasma frais congelé et de vitamine K. Le dosage des paramètres de la coagulation a mis en évidence un déficit isolé en FVII. Aucun inhibiteur du FVII n'a été détecté. Le déficit a été pris en charge avec succès par l'administration quotidienne de substitut du FVII (facteur VII-LFB®), pendant dix jours. Le facteur VII s'est ensuite normalisé vers le 12e jour. Les aspects physiopathologiques et thérapeutiques de ce rare déficit acquis sont présentés. We report a case of transient acquired and isolated factor VII deficiency associated with severe head trauma. A 16-year-old boy was involved in a motor vehicle accident. CT scan showed frontal brain contusion and a cerebral haematoma (5 cm). First prothrombine time (PT) was normal. Rapidly, a severe coagulopathy developed, unresponsiving to fresh frozen plasma and vitamin K. Haemostatic markers analysis showed an isolated deficiency of factor VII at 15%. No inhibitory activity against factor VII could be detected. We successfully treated the deficiency with intermittent intravenous human factor VII (factor VII-LFB®) during 10 days. Factor VII return to normal at 84%. Physiopathological and therapeutic aspects of this rare pathology are presented." @default.
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- W1964430250 date "2005-11-01" @default.
- W1964430250 modified "2023-09-27" @default.
- W1964430250 title "Déficit acquis et isolé en facteur VII contemporain d'un traumatisme crânien grave : utilisation du substitut de facteur VII (facteur VII-LFB®)" @default.
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- W1964430250 doi "https://doi.org/10.1016/j.annfar.2005.05.019" @default.
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