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- W1964442960 abstract "The bioavailability of three isoniazid formulations was assessed using a procedure specific for the free drug. Nine human volunteers, all slow acetylators, were each given 4×100 mg of isoniazid of three different tablet formulations at weekly intervals; the plasma drug levels were measured at different times during the first 24 hr. No significant differences (p>0.05) were detected among the three products as to relative bioavailability, peak plasma concentrations, Cmax, and the time of Cmax, tmax-Analysis of variance of the pharmacokinetic parameters obtained according to a one-compartment open model did not demonstrate any significant formulation or time effect but revealed a significant intersubject variation in all parameters involved." @default.
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- W1964442960 date "1977-12-01" @default.
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- W1964442960 title "Bioavailability of Three Isoniazid Formulations" @default.
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- W1964442960 doi "https://doi.org/10.1002/jps.2600661228" @default.
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