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- W1964501043 abstract "The accuracy of biomarkers for Alzheimer's disease (AD) can be best determined in well-characterized patients longitudinally followed to autopsy confirmation. Levels of CSF biomarkers may also track cognitive decline during disease progression, and their levels may be considered secondary endpoints in future therapeutic trials. Objective: To identify antemortem cerebrospinal fluid (CSF) diagnostic biomarkers that distinguish pathologically confirmed AD from cognitively normal (NL) subjects and patients with other neurodegenerative disorders such as frontotemporal lobar degeneration and dementia with Lewy bodies, and CSF biomarkers that correlate with cognition in AD and mild cognitive impairment (MCI). CSF samples were collected antemortem from 66 AD patients with AD and 25 patients with other neurodegenerative dementias followed longitudinally to neuropathologic confirmation, 42 longitudinally followed MCI patients, and 33 NL. Levels of 151 novel analytes were measured via a targeted multiplex panel enriched in cytokines, chemokines, and growth factors as well as established AD biomarkers (ApoE4 allele, and levels of Aβ42, tau, and p-tau181). AD is best distinguished from NL by a combination of traditional AD biomarkers that confer sensitivity, and multiplex biomarkers that confer specificity relative to NL. Two categories of biomarkers were identified: 1) analytes that specifically distinguish AD (especially CSF Aβ42 levels) from NL and other neurodegenerative disorders; and 2) analytes altered in multiple neurodegenerative diseases, but not in NL subjects. Six analytes were correlated with severity of cognitive impairment at CSF collection, and two were associated with subsequent cognitive decline in MCI. Our targeted proteomic screen revealed novel CSF biomarkers that distinguished AD from NL and other neurodegenerative disorders, and subsets of biomarkers that correlated with cognition and subsequent cognitive decline. A multiplex panel of CSF biomarkers can improve the antemortem diagnostic and prognostic classification of AD and MCI." @default.
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- W1964501043 date "2010-07-01" @default.
- W1964501043 modified "2023-09-27" @default.
- W1964501043 title "P3-252: Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment" @default.
- W1964501043 doi "https://doi.org/10.1016/j.jalz.2010.05.1752" @default.
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