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- W1964506355 endingPage "1203" @default.
- W1964506355 startingPage "1193" @default.
- W1964506355 abstract "Background: The mammalian target of rapamycin (mTOR) has emerged as an attractive cancer therapeutic target. Accordingly, several mTOR inhibitors (e.g., rapamycin and its analogs; rapalogs) are currently being tested in many cancer clinical trials. Despite the encouraging results showing that some rapalogs improved overall survival among patients with metastatic renal-cell carcinoma, the single-agent activity of rapalogs in most other tumor-types has been modest, at best. Objective: To review the current understanding of the mTOR axis and discuss potential strategies to enhance mTOR-targeted cancer therapy. Methods: Preclinical and clinical data in peer-reviewed reports on the novel biological and therapeutic parts of the mTOR axis are discussed. Conclusion: The mTOR axis involves complex regulatory networks. Inhibition of the mTOR axis with a rapalog induces feedback activation of several survival signaling pathways such as Akt activation, which, in turn, blunt rapalogs' anticancer efficacy. Thus, blockage or prevention of the activation of these survival signaling pathways may enhance mTOR-targeted cancer therapy." @default.
- W1964506355 created "2016-06-24" @default.
- W1964506355 creator A5022570940 @default.
- W1964506355 creator A5035869006 @default.
- W1964506355 date "2009-08-20" @default.
- W1964506355 modified "2023-09-23" @default.
- W1964506355 title "Enhancing mTOR-targeted cancer therapy" @default.
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