FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964517239> ?p ?o ?g. }

• W1964517239 endingPage "3213" @default.
• W1964517239 startingPage "3201" @default.
• W1964517239 abstract "The antigenic variability of tumor cells leading to dynamic changes in cancer epitope landscape along with escape from immune surveillance by down-regulating tumor antigen expression/presentation and immune tolerance are major obstacles for the design of effective vaccines. We have developed a novel concept for immunogen construction based on introduction of massive mutations within the epitopes targeting antigenically variable pathogens and diseases. Previously, we showed that these immunogens carrying large combinatorial libraries of mutated epitope variants, termed as variable epitope libraries (VELs), induce potent, broad and long lasting CD8+IFN-γ+ T-cell response as well as HIV-neutralizing antibodies. In this proof-of-concept study, we tested immunogenic properties and anti-tumor effects of the VELs bearing survivin-derived CTL epitope (GWEPDDNPI) variants in an aggressive metastatic mouse 4T1 breast tumor model. The constructed VELs had complexities of 10,500 and 8,000 individual members, generated as combinatorial M13 phage display and synthetic peptide libraries, respectively, with structural composition GWXPXDXPI, where X is any of 20 natural amino acids. Statistically significant tumor growth inhibition was observed in BALB/c mice immunized with the VELs in both prophylactic and therapeutic settings. Vaccinated mice developed epitope-specific spleen cell and CD8+ IFN-γ+ T-cell responses that recognize more than 50% of the panel of 87 mutated epitope variants, as demonstrated in T-cell proliferation assays and FACS analysis. These data indicate the feasibility of the application of this new class of immunogens based on VEL concept as an alternative approach for the development of molecular vaccines against cancer." @default.
• W1964517239 created "2016-06-24" @default.
• W1964517239 creator A5000462486 @default.
• W1964517239 creator A5000967400 @default.
• W1964517239 creator A5007672076 @default.
• W1964517239 creator A5011498911 @default.
• W1964517239 creator A5018973740 @default.
• W1964517239 creator A5019800587 @default.
• W1964517239 creator A5022830021 @default.
• W1964517239 creator A5051745913 @default.
• W1964517239 creator A5062047055 @default.
• W1964517239 creator A5067450152 @default.
• W1964517239 date "2014-11-01" @default.
• W1964517239 modified "2023-10-03" @default.
• W1964517239 title "Variable epitope library carrying heavily mutated survivin-derived CTL epitope variants as a new class of efficient vaccine immunogen tested in a mouse model of breast cancer" @default.
• W1964517239 cites W1808049880 @default.
• W1964517239 cites W1967394748 @default.
• W1964517239 cites W1967933377 @default.
• W1964517239 cites W1981553458 @default.
• W1964517239 cites W1983986735 @default.
• W1964517239 cites W1984339585 @default.
• W1964517239 cites W1987288591 @default.
• W1964517239 cites W2004305672 @default.
• W1964517239 cites W2011865418 @default.
• W1964517239 cites W2018397340 @default.
• W1964517239 cites W2023570941 @default.
• W1964517239 cites W2037242921 @default.
• W1964517239 cites W2042784923 @default.
• W1964517239 cites W2045704991 @default.
• W1964517239 cites W2045795620 @default.
• W1964517239 cites W2048758805 @default.
• W1964517239 cites W2055011603 @default.
• W1964517239 cites W2056371902 @default.
• W1964517239 cites W2062889582 @default.
• W1964517239 cites W2063728375 @default.
• W1964517239 cites W2075697716 @default.
• W1964517239 cites W2082519303 @default.
• W1964517239 cites W2084768405 @default.
• W1964517239 cites W2086493960 @default.
• W1964517239 cites W2087751238 @default.
• W1964517239 cites W2087783022 @default.
• W1964517239 cites W2088335117 @default.
• W1964517239 cites W2090203631 @default.
• W1964517239 cites W2108706633 @default.
• W1964517239 cites W2115955652 @default.
• W1964517239 cites W2120338564 @default.
• W1964517239 cites W2132361489 @default.
• W1964517239 cites W2140380780 @default.
• W1964517239 cites W2144439874 @default.
• W1964517239 cites W2144577255 @default.
• W1964517239 cites W2146715702 @default.
• W1964517239 cites W2168274979 @default.
• W1964517239 cites W2320919314 @default.
• W1964517239 cites W4237778044 @default.
• W1964517239 doi "https://doi.org/10.4161/hv.29679" @default.
• W1964517239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4514078" @default.
• W1964517239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25483665" @default.
• W1964517239 hasPublicationYear "2014" @default.
• W1964517239 type Work @default.
• W1964517239 sameAs 1964517239 @default.
• W1964517239 citedByCount "19" @default.
• W1964517239 countsByYear W19645172392016 @default.
• W1964517239 countsByYear W19645172392017 @default.
• W1964517239 countsByYear W19645172392018 @default.
• W1964517239 countsByYear W19645172392020 @default.
• W1964517239 countsByYear W19645172392021 @default.
• W1964517239 countsByYear W19645172392022 @default.
• W1964517239 countsByYear W19645172392023 @default.
• W1964517239 crossrefType "journal-article" @default.
• W1964517239 hasAuthorship W1964517239A5000462486 @default.
• W1964517239 hasAuthorship W1964517239A5000967400 @default.
• W1964517239 hasAuthorship W1964517239A5007672076 @default.
• W1964517239 hasAuthorship W1964517239A5011498911 @default.
• W1964517239 hasAuthorship W1964517239A5018973740 @default.
• W1964517239 hasAuthorship W1964517239A5019800587 @default.
• W1964517239 hasAuthorship W1964517239A5022830021 @default.
• W1964517239 hasAuthorship W1964517239A5051745913 @default.
• W1964517239 hasAuthorship W1964517239A5062047055 @default.
• W1964517239 hasAuthorship W1964517239A5067450152 @default.
• W1964517239 hasBestOaLocation W19645172391 @default.
• W1964517239 hasConcept C147483822 @default.
• W1964517239 hasConcept C147969180 @default.
• W1964517239 hasConcept C159047783 @default.
• W1964517239 hasConcept C159654299 @default.
• W1964517239 hasConcept C167672396 @default.
• W1964517239 hasConcept C195616568 @default.
• W1964517239 hasConcept C203014093 @default.
• W1964517239 hasConcept C2779909307 @default.
• W1964517239 hasConcept C2781241564 @default.
• W1964517239 hasConcept C502942594 @default.
• W1964517239 hasConcept C542903549 @default.
• W1964517239 hasConcept C78598654 @default.
• W1964517239 hasConcept C86803240 @default.
• W1964517239 hasConcept C8891405 @default.
• W1964517239 hasConceptScore W1964517239C147483822 @default.
• W1964517239 hasConceptScore W1964517239C147969180 @default.
• W1964517239 hasConceptScore W1964517239C159047783 @default.
• W1964517239 hasConceptScore W1964517239C159654299 @default.

• next