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• W1964520746 abstract "Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncology area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inherent in lead structure 1 that resulted in the identification of Smoothened inhibitor 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (PF-04449913, 26), which has been advanced to human clinical studies." @default.
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• W1964520746 date "2011-12-21" @default.
• W1964520746 modified "2023-10-17" @default.
• W1964520746 title "Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened" @default.
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• W1964520746 doi "https://doi.org/10.1021/ml2002423" @default.
• W1964520746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4025788" @default.
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