FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964522609> ?p ?o ?g. }

• W1964522609 endingPage "943" @default.
• W1964522609 startingPage "931" @default.
• W1964522609 abstract "Hearts with compensatory pressure-overload hypertrophy show an increased intracardiac activation of angiotensin II that may contribute to ischemic diastolic dysfunction. We studied whether pressure-overload hypertrophy in response to aortic banding would result in exaggerated diastolic dysfunction during low-flow ischemia and whether the specific inhibition of the cardiac angiotensin converting enzyme by enalaprilat would modify systolic and diastolic function during ischemia and reperfusion in either hypertrophied or nonhypertrophied hearts. Isolated, red blood cell-perfused isovolumic nonhypertrophied and hypertrophied rat hearts were subjected to enalaprilat (2.5 x 10(-7) M final concentration) infusion during 20 minutes of baseline perfusion and during 30 minutes of low-flow ischemia and 30 minutes of reperfusion. Coronary flow per gram was similar in nonhypertrophied and hypertrophied hearts during baseline perfusion, ischemia, and reperfusion. At baseline, left ventricular developed pressure was higher in hypertrophied than nonhypertrophied hearts in untreated groups (224 +/- 8 versus 150 +/- 9 mm Hg; p less than 0.01) and in enalaprilat-treated groups (223 +/- 9 versus 145 +/- 8 mm Hg; p less than 0.01). During low-flow ischemia, left ventricular developed pressure was depressed but similar in all groups. All groups showed deterioration of diastolic function; however, left ventricular end-diastolic pressure increased to a significantly higher level in untreated hypertrophied than in nonhypertrophied hearts (65 +/- 7 versus 33 +/- 3 mm Hg; p less than 0.001). Enalaprilat had no effect in nonhypertrophied hearts, but it significantly attenuated the greater increase in left ventricular end-diastolic pressure in hypertrophied hearts treated with enalaprilat compared with no drug (65 +/- 7 versus 50 +/- 5 mm Hg; p less than 0.01). The beneficial effect could not be explained by differences in coronary blood flow per gram left ventricular weight, glycolytic flux as reported by lactate production, myocardial water content, oxygen consumption, and tissue levels of glycogen and high energy phosphate compounds. During reperfusion, all hearts showed a partial recovery of developed pressure to 70-74% of initial values. No effect of enalaprilat could be detected during reperfusion on systolic and diastolic function or restoration of tissue levels of high energy compounds. In conclusion, our experiments show that hypertrophied red blood cell-perfused hearts manifest a severe impairment of left ventricular diastolic relaxation in response to low-flow ischemia in comparison with control hearts. Further, our experiments support the hypothesis that the enhanced conversion of angiotensin I to angiotensin II in rats with pressure-overload hypertrophy contributes to the enhanced sensitivity of hypertrophied hearts to diastolic dysfunction during low-flow ischemia." @default.
• W1964522609 created "2016-06-24" @default.
• W1964522609 creator A5056334264 @default.
• W1964522609 creator A5085665354 @default.
• W1964522609 creator A5087879929 @default.
• W1964522609 creator A5090004654 @default.
• W1964522609 date "1992-05-01" @default.
• W1964522609 modified "2023-10-16" @default.
• W1964522609 title "Exacerbation of left ventricular ischemic diastolic dysfunction by pressure-overload hypertrophy. Modification by specific inhibition of cardiac angiotensin converting enzyme." @default.
• W1964522609 cites W1481710938 @default.
• W1964522609 cites W1967286519 @default.
• W1964522609 cites W1968304612 @default.
• W1964522609 cites W1969643800 @default.
• W1964522609 cites W1979048402 @default.
• W1964522609 cites W1981723678 @default.
• W1964522609 cites W1984041314 @default.
• W1964522609 cites W1984841963 @default.
• W1964522609 cites W1991161134 @default.
• W1964522609 cites W2007550314 @default.
• W1964522609 cites W2023017689 @default.
• W1964522609 cites W2026635129 @default.
• W1964522609 cites W2029130094 @default.
• W1964522609 cites W2029828949 @default.
• W1964522609 cites W2033943371 @default.
• W1964522609 cites W2043045234 @default.
• W1964522609 cites W2044881190 @default.
• W1964522609 cites W2054301807 @default.
• W1964522609 cites W2055426200 @default.
• W1964522609 cites W2061205761 @default.
• W1964522609 cites W2067478997 @default.
• W1964522609 cites W2124307551 @default.
• W1964522609 cites W2129152732 @default.
• W1964522609 cites W2129925176 @default.
• W1964522609 cites W2132330417 @default.
• W1964522609 cites W2137850606 @default.
• W1964522609 cites W2162616464 @default.
• W1964522609 cites W2169680697 @default.
• W1964522609 cites W2410336926 @default.
• W1964522609 cites W2412342209 @default.
• W1964522609 cites W2413552267 @default.
• W1964522609 cites W2417374334 @default.
• W1964522609 cites W2496090432 @default.
• W1964522609 doi "https://doi.org/10.1161/01.res.70.5.931" @default.
• W1964522609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1314716" @default.
• W1964522609 hasPublicationYear "1992" @default.
• W1964522609 type Work @default.
• W1964522609 sameAs 1964522609 @default.
• W1964522609 citedByCount "58" @default.
• W1964522609 countsByYear W19645226092013 @default.
• W1964522609 countsByYear W19645226092014 @default.
• W1964522609 countsByYear W19645226092016 @default.
• W1964522609 countsByYear W19645226092020 @default.
• W1964522609 crossrefType "journal-article" @default.
• W1964522609 hasAuthorship W1964522609A5056334264 @default.
• W1964522609 hasAuthorship W1964522609A5085665354 @default.
• W1964522609 hasAuthorship W1964522609A5087879929 @default.
• W1964522609 hasAuthorship W1964522609A5090004654 @default.
• W1964522609 hasBestOaLocation W19645226091 @default.
• W1964522609 hasConcept C126322002 @default.
• W1964522609 hasConcept C146957229 @default.
• W1964522609 hasConcept C164705383 @default.
• W1964522609 hasConcept C167414201 @default.
• W1964522609 hasConcept C26635844 @default.
• W1964522609 hasConcept C27016395 @default.
• W1964522609 hasConcept C2776002628 @default.
• W1964522609 hasConcept C2777814262 @default.
• W1964522609 hasConcept C2778271984 @default.
• W1964522609 hasConcept C2779611605 @default.
• W1964522609 hasConcept C2908929049 @default.
• W1964522609 hasConcept C3018791406 @default.
• W1964522609 hasConcept C541997718 @default.
• W1964522609 hasConcept C57900726 @default.
• W1964522609 hasConcept C71924100 @default.
• W1964522609 hasConcept C84393581 @default.
• W1964522609 hasConceptScore W1964522609C126322002 @default.
• W1964522609 hasConceptScore W1964522609C146957229 @default.
• W1964522609 hasConceptScore W1964522609C164705383 @default.
• W1964522609 hasConceptScore W1964522609C167414201 @default.
• W1964522609 hasConceptScore W1964522609C26635844 @default.
• W1964522609 hasConceptScore W1964522609C27016395 @default.
• W1964522609 hasConceptScore W1964522609C2776002628 @default.
• W1964522609 hasConceptScore W1964522609C2777814262 @default.
• W1964522609 hasConceptScore W1964522609C2778271984 @default.
• W1964522609 hasConceptScore W1964522609C2779611605 @default.
• W1964522609 hasConceptScore W1964522609C2908929049 @default.
• W1964522609 hasConceptScore W1964522609C3018791406 @default.
• W1964522609 hasConceptScore W1964522609C541997718 @default.
• W1964522609 hasConceptScore W1964522609C57900726 @default.
• W1964522609 hasConceptScore W1964522609C71924100 @default.
• W1964522609 hasConceptScore W1964522609C84393581 @default.
• W1964522609 hasIssue "5" @default.
• W1964522609 hasLocation W19645226091 @default.
• W1964522609 hasLocation W19645226092 @default.
• W1964522609 hasOpenAccess W1964522609 @default.
• W1964522609 hasPrimaryLocation W19645226091 @default.
• W1964522609 hasRelatedWork W150824932 @default.
• W1964522609 hasRelatedWork W1964522609 @default.
• W1964522609 hasRelatedWork W1977068851 @default.

• next