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• W1964536849 abstract "There is evidence that apoptotic cell death contributes to the loss of denervated muscle fibers. In 17 patients with neurogenic muscular atrophy, we studied the expression of the apoptosis mediators APAF-1/caspase-9 and degrading caspases-2, -3, and -7 by immunohistochemical and western blot analyses. Muscle with neurogenic atrophy showed distinct upregulation of caspase-9 and -7 and no expression for APAF-1 (apoptosis protease-activating factor-1) and caspase-2 and -3. Expression of caspase-7 was restricted to atrophic fibers, but caspase-9 was also found in normal-sized muscle fibers where its expression was often confined to single fiber segments. These findings indicate that upregulated expression of caspase-9 can initiate the proteolytic cascade involving the downstream executioner caspase-7, which mediates degradation of denervated muscle fibers. However, apoptotic events may be restricted to single muscle-fiber segments, where apoptotic cell degradation contributes to the long-term process of atrophy. Pharmacological inhibition of caspases may be a therapeutic strategy in diminishing muscle atrophy." @default.
• W1964536849 created "2016-06-24" @default.
• W1964536849 creator A5028644395 @default.
• W1964536849 creator A5057991373 @default.
• W1964536849 creator A5072407338 @default.
• W1964536849 date "2004-12-29" @default.
• W1964536849 modified "2023-10-14" @default.
• W1964536849 title "Expression patterns of initiator and effector caspases in denervated human skeletal muscle" @default.
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• W1964536849 doi "https://doi.org/10.1002/mus.20253" @default.
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