FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964539717> ?p ?o ?g. }

• W1964539717 abstract "The MS4A gene family in humans includes CD20 and at least 15 other genes. CD20 exists as homo-oligomers in the plasma membrane, however different MS4A proteins expressed in the same cell may hetero-oligomerize. Given the importance of CD20 in B-cell function and as a therapeutic target, we sought to explore the potential for CD20 hetero-oligomerization with other MS4A proteins. We investigated expression in primary human B-cells of the four MS4A genes previously shown to be expressed in human B-cell lines (MS4A4A, MS4A6A, MS4A7, MS4A8B), as well as two genes comprising the closely related TMEM176 gene family, with a view to identifying candidates for future investigation at the protein level. TMEM176A and TMEM176B transcripts were either not detected, or were detected at relatively low levels in a minority of donor B-cell samples. MS4A4A and MS4A8B transcripts were not detected in any normal B-cell sample. MS4A6A and MS4A7 transcripts were detected at low levels in most samples, however the corresponding proteins were not at the plasma membrane when expressed as GFP conjugates in BJAB cells. We also examined expression of these genes in chronic lymphocytic leukemia (CLL), and found that it was similar to normal B-cells with two exceptions. First, whereas MS4A4A expression was undetected in normal B-cells, it was expressed in 1/14 CLL samples. Second, compared to expression levels in normal B-cells, MS4A6A transcripts were elevated in 4/14 CLL samples. In summary, none of the MS4A/TMEM176 genes tested was expressed at high levels in normal or in most CLL B-cells. MS4A6A and MS4A7 were expressed at low levels in most B-cell samples, however the corresponding proteins may not be positioned at the plasma membrane. Altogether, these data suggest that CD20 normally does not form hetero-oligomers with other MS4A proteins and that there are unlikely to be other MS4A proteins in CLL that might provide useful alternate therapeutic targets." @default.
• W1964539717 created "2016-06-24" @default.
• W1964539717 creator A5011382185 @default.
• W1964539717 creator A5028055443 @default.
• W1964539717 creator A5033710140 @default.
• W1964539717 creator A5036661480 @default.
• W1964539717 creator A5037135286 @default.
• W1964539717 creator A5040148781 @default.
• W1964539717 creator A5045295177 @default.
• W1964539717 creator A5048372500 @default.
• W1964539717 creator A5056340336 @default.
• W1964539717 creator A5078987119 @default.
• W1964539717 creator A5084879148 @default.
• W1964539717 date "2013-01-01" @default.
• W1964539717 modified "2023-09-25" @default.
• W1964539717 title "Expression of MS4A and TMEM176 Genes in Human B Lymphocytes" @default.
• W1964539717 cites W1959625971 @default.
• W1964539717 cites W1964486259 @default.
• W1964539717 cites W196476257 @default.
• W1964539717 cites W1978233348 @default.
• W1964539717 cites W1983005038 @default.
• W1964539717 cites W1983295913 @default.
• W1964539717 cites W1998993441 @default.
• W1964539717 cites W2004635475 @default.
• W1964539717 cites W2005942119 @default.
• W1964539717 cites W2009109361 @default.
• W1964539717 cites W2010567193 @default.
• W1964539717 cites W2011922549 @default.
• W1964539717 cites W2027374210 @default.
• W1964539717 cites W2036251477 @default.
• W1964539717 cites W2041871285 @default.
• W1964539717 cites W2044837571 @default.
• W1964539717 cites W2056534555 @default.
• W1964539717 cites W2058162047 @default.
• W1964539717 cites W2059432324 @default.
• W1964539717 cites W2065900855 @default.
• W1964539717 cites W2069524809 @default.
• W1964539717 cites W2079148884 @default.
• W1964539717 cites W2085100411 @default.
• W1964539717 cites W2096055205 @default.
• W1964539717 cites W2103378909 @default.
• W1964539717 cites W2108244474 @default.
• W1964539717 cites W2113170542 @default.
• W1964539717 cites W2122725450 @default.
• W1964539717 cites W2128551987 @default.
• W1964539717 cites W2130234361 @default.
• W1964539717 cites W2134677113 @default.
• W1964539717 cites W2136846143 @default.
• W1964539717 cites W2141682526 @default.
• W1964539717 cites W2163100333 @default.
• W1964539717 cites W2415998525 @default.
• W1964539717 cites W269321395 @default.
• W1964539717 doi "https://doi.org/10.3389/fimmu.2013.00195" @default.
• W1964539717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3711070" @default.
• W1964539717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23874341" @default.
• W1964539717 hasPublicationYear "2013" @default.
• W1964539717 type Work @default.
• W1964539717 sameAs 1964539717 @default.
• W1964539717 citedByCount "37" @default.
• W1964539717 countsByYear W19645397172014 @default.
• W1964539717 countsByYear W19645397172015 @default.
• W1964539717 countsByYear W19645397172016 @default.
• W1964539717 countsByYear W19645397172017 @default.
• W1964539717 countsByYear W19645397172018 @default.
• W1964539717 countsByYear W19645397172019 @default.
• W1964539717 countsByYear W19645397172020 @default.
• W1964539717 countsByYear W19645397172021 @default.
• W1964539717 countsByYear W19645397172022 @default.
• W1964539717 countsByYear W19645397172023 @default.
• W1964539717 crossrefType "journal-article" @default.
• W1964539717 hasAuthorship W1964539717A5011382185 @default.
• W1964539717 hasAuthorship W1964539717A5028055443 @default.
• W1964539717 hasAuthorship W1964539717A5033710140 @default.
• W1964539717 hasAuthorship W1964539717A5036661480 @default.
• W1964539717 hasAuthorship W1964539717A5037135286 @default.
• W1964539717 hasAuthorship W1964539717A5040148781 @default.
• W1964539717 hasAuthorship W1964539717A5045295177 @default.
• W1964539717 hasAuthorship W1964539717A5048372500 @default.
• W1964539717 hasAuthorship W1964539717A5056340336 @default.
• W1964539717 hasAuthorship W1964539717A5078987119 @default.
• W1964539717 hasAuthorship W1964539717A5084879148 @default.
• W1964539717 hasBestOaLocation W19645397171 @default.
• W1964539717 hasConcept C104317684 @default.
• W1964539717 hasConcept C1491633281 @default.
• W1964539717 hasConcept C150194340 @default.
• W1964539717 hasConcept C153911025 @default.
• W1964539717 hasConcept C159654299 @default.
• W1964539717 hasConcept C18031839 @default.
• W1964539717 hasConcept C2777938653 @default.
• W1964539717 hasConcept C2778453870 @default.
• W1964539717 hasConcept C2778461978 @default.
• W1964539717 hasConcept C2778957590 @default.
• W1964539717 hasConcept C54355233 @default.
• W1964539717 hasConcept C553184892 @default.
• W1964539717 hasConcept C81885089 @default.
• W1964539717 hasConcept C86803240 @default.
• W1964539717 hasConceptScore W1964539717C104317684 @default.
• W1964539717 hasConceptScore W1964539717C1491633281 @default.
• W1964539717 hasConceptScore W1964539717C150194340 @default.
• W1964539717 hasConceptScore W1964539717C153911025 @default.

• next