FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964542289> ?p ?o ?g. }

• W1964542289 endingPage "1618" @default.
• W1964542289 startingPage "1609" @default.
• W1964542289 abstract "Abstract Objective Previous studies have shown that the suppressive capacity of CD4+,CD25++ T cells is compromised in patients with rheumatoid arthritis (RA) and restored by anti–tumor necrosis factor α (anti‐TNFα) therapy. Given the lack of specific cell surface markers for human Treg cells, this study aimed to define surface markers for identifying and enriching Treg cells with enhanced regulatory ability within the CD4+,CD25++ T cell compartment and to provide additional understanding of the effects of anti‐TNFα antibodies in humans. Methods The expression of membrane‐bound TNFα in human peripheral blood CD4+ T cells was analyzed by flow cytometry in healthy individuals and RA patients before and after anti‐TNFα treatment. Membrane‐bound TNFα‐positive and TNFα‐negative CD4+,CD25++ T cells were purified by fluorescence‐activated cell sorting, and their suppressive capacity was assessed in vitro by a standard suppression assay. Results A substantial number of CD4+,CD25++ T cells expressed membrane‐bound TNFα. Membrane‐bound TNFα‐positive CD4+,CD25++ T cells displayed reduced antiinflammatory cytokine production and less potent suppressor capacity, since 4 times more cells were required to achieve 50% inhibition compared with their membrane‐bound TNFα‐negative counterparts. Treatment of RA patients with TNFα‐specific antibodies led to a reduction in the number of membrane‐bound TNFα‐positive CD4+,CD25++ T cells from peripheral blood. Conclusion Our data indicate that the absence of membrane‐bound TNFα on CD4+,CD25++ T cells can be used to characterize and enrich for Treg cells with maximal suppressor potency. Enrichment of membrane‐bound TNFα‐negative CD4+,CD25+ cells in the CD4+,CD25++ T cell compartment may contribute to restoring the compromised suppressive ability of CD4+,CD25++ T cell populations in RA patients after anti‐TNFα treatment." @default.
• W1964542289 created "2016-06-24" @default.
• W1964542289 creator A5023177378 @default.
• W1964542289 creator A5024219119 @default.
• W1964542289 creator A5049437946 @default.
• W1964542289 creator A5052842332 @default.
• W1964542289 creator A5058954885 @default.
• W1964542289 date "2008-05-31" @default.
• W1964542289 modified "2023-10-18" @default.
• W1964542289 title "Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor α" @default.
• W1964542289 cites W1489954132 @default.
• W1964542289 cites W1560277370 @default.
• W1964542289 cites W1782419634 @default.
• W1964542289 cites W1967907511 @default.
• W1964542289 cites W1968715761 @default.
• W1964542289 cites W1974422789 @default.
• W1964542289 cites W1984909066 @default.
• W1964542289 cites W1985284364 @default.
• W1964542289 cites W1990521474 @default.
• W1964542289 cites W1996465395 @default.
• W1964542289 cites W1999227421 @default.
• W1964542289 cites W2000368283 @default.
• W1964542289 cites W2010281909 @default.
• W1964542289 cites W2022172040 @default.
• W1964542289 cites W2033330275 @default.
• W1964542289 cites W2039683692 @default.
• W1964542289 cites W2045236396 @default.
• W1964542289 cites W2049494801 @default.
• W1964542289 cites W2060859321 @default.
• W1964542289 cites W2085486418 @default.
• W1964542289 cites W2086721113 @default.
• W1964542289 cites W2093383759 @default.
• W1964542289 cites W2097057955 @default.
• W1964542289 cites W2098919737 @default.
• W1964542289 cites W2110177517 @default.
• W1964542289 cites W2118268169 @default.
• W1964542289 cites W2120313632 @default.
• W1964542289 cites W2122445377 @default.
• W1964542289 cites W2123249923 @default.
• W1964542289 cites W2126265064 @default.
• W1964542289 cites W2130822830 @default.
• W1964542289 cites W2135280067 @default.
• W1964542289 cites W2136757504 @default.
• W1964542289 cites W2139019810 @default.
• W1964542289 cites W2144152742 @default.
• W1964542289 cites W2145030204 @default.
• W1964542289 cites W2146722884 @default.
• W1964542289 cites W2148245227 @default.
• W1964542289 cites W2150747144 @default.
• W1964542289 cites W2152348310 @default.
• W1964542289 cites W2154515402 @default.
• W1964542289 cites W2156959273 @default.
• W1964542289 cites W2156964052 @default.
• W1964542289 cites W2158092720 @default.
• W1964542289 cites W2158200061 @default.
• W1964542289 cites W2159346740 @default.
• W1964542289 cites W2166732256 @default.
• W1964542289 cites W2169233545 @default.
• W1964542289 cites W2169887956 @default.
• W1964542289 cites W2176899369 @default.
• W1964542289 doi "https://doi.org/10.1002/art.23460" @default.
• W1964542289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18512781" @default.
• W1964542289 hasPublicationYear "2008" @default.
• W1964542289 type Work @default.
• W1964542289 sameAs 1964542289 @default.
• W1964542289 citedByCount "30" @default.
• W1964542289 countsByYear W19645422892012 @default.
• W1964542289 countsByYear W19645422892013 @default.
• W1964542289 countsByYear W19645422892014 @default.
• W1964542289 countsByYear W19645422892015 @default.
• W1964542289 countsByYear W19645422892018 @default.
• W1964542289 countsByYear W19645422892019 @default.
• W1964542289 countsByYear W19645422892023 @default.
• W1964542289 crossrefType "journal-article" @default.
• W1964542289 hasAuthorship W1964542289A5023177378 @default.
• W1964542289 hasAuthorship W1964542289A5024219119 @default.
• W1964542289 hasAuthorship W1964542289A5049437946 @default.
• W1964542289 hasAuthorship W1964542289A5052842332 @default.
• W1964542289 hasAuthorship W1964542289A5058954885 @default.
• W1964542289 hasConcept C137061746 @default.
• W1964542289 hasConcept C153911025 @default.
• W1964542289 hasConcept C17991360 @default.
• W1964542289 hasConcept C202751555 @default.
• W1964542289 hasConcept C203014093 @default.
• W1964542289 hasConcept C2776090121 @default.
• W1964542289 hasConcept C2778630268 @default.
• W1964542289 hasConcept C2778690821 @default.
• W1964542289 hasConcept C502942594 @default.
• W1964542289 hasConcept C553184892 @default.
• W1964542289 hasConcept C55493867 @default.
• W1964542289 hasConcept C79484868 @default.
• W1964542289 hasConcept C86803240 @default.
• W1964542289 hasConcept C8891405 @default.
• W1964542289 hasConceptScore W1964542289C137061746 @default.
• W1964542289 hasConceptScore W1964542289C153911025 @default.
• W1964542289 hasConceptScore W1964542289C17991360 @default.
• W1964542289 hasConceptScore W1964542289C202751555 @default.
• W1964542289 hasConceptScore W1964542289C203014093 @default.

• next