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- W1964546822 abstract "Abstract Studies are reported on the viscosity (η) and elastic modulus (γ) in dynamic shear and on the rigidity (τ) in steady shear of surface layers of highly purified human and bovine fibrinogen. The measurements were made with a modified Weissenberg rheogoniometer. Preparations of highly purified human and bovine fibrinogen of 98 to 100 per cent coagulability were employed. High values of viscosity and viscoelasticity were found with varying concentrations of human and bovine fibrinogen from 0.4 to 0.00004. The significance of these findings is discussed in relation to blood-bubble generation or the embolization of fibrinogen or plasma coated air bubbles in decompression sickness. The rigidity of the fibrinogen surface layers was found to depend on the pH. Two different buffers were employed at pH from 5.4 to 8.7. The τ values between pH 6.5 and 7.6 did not show changes in rigidity. At pH below 6.5, τ values increased markedly and at pH above 7.6, decreases in τ were recorded. The findings, obtained at pH below 6.5, may be of special significance in the understanding of what may trigger the initiation of thrombus formation in the circulation, in particular the microcirculation, by fibrinogen clotting without thrombin participation, i.e., the aggregation and gelation of fibrinogen on the endothelium, both in thrombogenesis and incipient hemostasis." @default.
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- W1964546822 date "1980-04-01" @default.
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- W1964546822 title "Viscoelasticity studies of surface layers of highly purified fibrinogen (Fg) systems and the role of pH on the rigidity of such layers" @default.
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- W1964546822 doi "https://doi.org/10.1016/0049-3848(80)90185-1" @default.
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