FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1964547696> ?p ?o ?g. }

• W1964547696 endingPage "107" @default.
• W1964547696 startingPage "101" @default.
• W1964547696 abstract "Insulin stimulates membrane phospholipid metabolism and activates protein kinase C (PKC) in its peripheral target tissues. Additionally, insulin can stimulate PKC activity in cultured fetal chick neurons. In the present study, we tested whether insulin can stimulate membrane phospholipid metabolism in the rat hippocampus, a CNS region in which insulin has been reported to stimulate the phosphorylation of a PKC substrate protein and to suppress spontaneous electrical activity of pyramidal cells. Concentrations of 1, 10 and 100 nM insulin significantly stimulated the accumulation of [3H]inositol phosphate ([3H]IP1) and [3H]IP2 in hippocampal slices labelled with [3H]myoinositol. Significant (P < 0.05) increases of hippocampal diacylglycerol (a product of phospoinositol hydrolysis) content were observed at 1, 5 or 10 min of incubation with 50 or 100 nM insulin. Addition of tetrodotoxin resulted in a suppression of insulin stimulation of [3H]IP1 release, suggesting that insulin effects may be indirect and mediated via release of an endogenous neuronal transmitter within the hippocampus. Norepinephrine has been shown to both stimulate PI turnover and suppress the spontaneous electrical activity of pyramidal cells viaα1-adrenergic receptors. Therefore, we tested whether the effects of insulin were mediated by norepinephrine. We measured [3H]IP1 release in the presence or absence of theα1-adrenergic antagonists prazobind and prazosin. These compounds blocked insulin stimulation of IP1 accumulation, suggesting that the action of insulin to stimulate PI turnover is secondary to enhancement of endogenous noradrenergic activity within the hippocampus." @default.
• W1964547696 created "2016-06-24" @default.
• W1964547696 creator A5005405737 @default.
• W1964547696 creator A5086775335 @default.
• W1964547696 date "1991-05-01" @default.
• W1964547696 modified "2023-10-17" @default.
• W1964547696 title "Insulin stimulates membrane phospholipid metabolism by enhancing endogenousα1-adrenergic activity in the rat hippocampus" @default.
• W1964547696 cites W103172802 @default.
• W1964547696 cites W129343397 @default.
• W1964547696 cites W1480299551 @default.
• W1964547696 cites W1537867053 @default.
• W1964547696 cites W1566898379 @default.
• W1964547696 cites W1676701054 @default.
• W1964547696 cites W1840231899 @default.
• W1964547696 cites W1889236699 @default.
• W1964547696 cites W1964597676 @default.
• W1964547696 cites W1966515357 @default.
• W1964547696 cites W1971244092 @default.
• W1964547696 cites W1974194714 @default.
• W1964547696 cites W1978237239 @default.
• W1964547696 cites W1995677758 @default.
• W1964547696 cites W2005566523 @default.
• W1964547696 cites W2008245136 @default.
• W1964547696 cites W2009553840 @default.
• W1964547696 cites W2012335673 @default.
• W1964547696 cites W2021687076 @default.
• W1964547696 cites W2028006381 @default.
• W1964547696 cites W2043813981 @default.
• W1964547696 cites W2048342653 @default.
• W1964547696 cites W2051743364 @default.
• W1964547696 cites W2057013554 @default.
• W1964547696 cites W2058581174 @default.
• W1964547696 cites W2062021966 @default.
• W1964547696 cites W2072099683 @default.
• W1964547696 cites W2075190453 @default.
• W1964547696 cites W2079557858 @default.
• W1964547696 cites W2103920508 @default.
• W1964547696 cites W2176848385 @default.
• W1964547696 cites W2316474967 @default.
• W1964547696 cites W2340541742 @default.
• W1964547696 cites W2427308280 @default.
• W1964547696 doi "https://doi.org/10.1016/0006-8993(91)90410-w" @default.
• W1964547696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1653632" @default.
• W1964547696 hasPublicationYear "1991" @default.
• W1964547696 type Work @default.
• W1964547696 sameAs 1964547696 @default.
• W1964547696 citedByCount "29" @default.
• W1964547696 countsByYear W19645476962012 @default.
• W1964547696 countsByYear W19645476962013 @default.
• W1964547696 crossrefType "journal-article" @default.
• W1964547696 hasAuthorship W1964547696A5005405737 @default.
• W1964547696 hasAuthorship W1964547696A5086775335 @default.
• W1964547696 hasConcept C112446052 @default.
• W1964547696 hasConcept C11960822 @default.
• W1964547696 hasConcept C126322002 @default.
• W1964547696 hasConcept C134018914 @default.
• W1964547696 hasConcept C148762608 @default.
• W1964547696 hasConcept C158453852 @default.
• W1964547696 hasConcept C16613235 @default.
• W1964547696 hasConcept C170493617 @default.
• W1964547696 hasConcept C185592680 @default.
• W1964547696 hasConcept C195794163 @default.
• W1964547696 hasConcept C2777391703 @default.
• W1964547696 hasConcept C2778918659 @default.
• W1964547696 hasConcept C2779306644 @default.
• W1964547696 hasConcept C41625074 @default.
• W1964547696 hasConcept C55493867 @default.
• W1964547696 hasConcept C71924100 @default.
• W1964547696 hasConcept C86803240 @default.
• W1964547696 hasConceptScore W1964547696C112446052 @default.
• W1964547696 hasConceptScore W1964547696C11960822 @default.
• W1964547696 hasConceptScore W1964547696C126322002 @default.
• W1964547696 hasConceptScore W1964547696C134018914 @default.
• W1964547696 hasConceptScore W1964547696C148762608 @default.
• W1964547696 hasConceptScore W1964547696C158453852 @default.
• W1964547696 hasConceptScore W1964547696C16613235 @default.
• W1964547696 hasConceptScore W1964547696C170493617 @default.
• W1964547696 hasConceptScore W1964547696C185592680 @default.
• W1964547696 hasConceptScore W1964547696C195794163 @default.
• W1964547696 hasConceptScore W1964547696C2777391703 @default.
• W1964547696 hasConceptScore W1964547696C2778918659 @default.
• W1964547696 hasConceptScore W1964547696C2779306644 @default.
• W1964547696 hasConceptScore W1964547696C41625074 @default.
• W1964547696 hasConceptScore W1964547696C55493867 @default.
• W1964547696 hasConceptScore W1964547696C71924100 @default.
• W1964547696 hasConceptScore W1964547696C86803240 @default.
• W1964547696 hasIssue "1" @default.
• W1964547696 hasLocation W19645476961 @default.
• W1964547696 hasLocation W19645476962 @default.
• W1964547696 hasOpenAccess W1964547696 @default.
• W1964547696 hasPrimaryLocation W19645476961 @default.
• W1964547696 hasRelatedWork W1582753616 @default.
• W1964547696 hasRelatedWork W1967839773 @default.
• W1964547696 hasRelatedWork W2001668713 @default.
• W1964547696 hasRelatedWork W2003179917 @default.
• W1964547696 hasRelatedWork W2013175365 @default.
• W1964547696 hasRelatedWork W2024170705 @default.
• W1964547696 hasRelatedWork W2133219962 @default.

• next